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Revista do Instituto de Medicina Tropical de São Paulo

On-line version ISSN 1678-9946

Rev. Inst. Med. trop. S. Paulo vol.28 no.4 São Paulo July/Aug. 1986

http://dx.doi.org/10.1590/S0036-46651986000400010 

 

 

Schistosoma mansoni: effects of anesthetics and antimonial drugs on worm shift in the mouse

 

Schistosoma mansoni: efeitos de anestésicos e antimonial (Triostib R) sobre o deslocamento de vermes no camundongo

 

 

José Renan da Cunha-MeloI; Paulo Marcos Z. CoelhoII

IDepartamento de Cirurgia, Faculdade de Medicina da Universidade Federal de Minas Gerais
IIDepartamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais. Caixa Postal 2486. CEP 30000 Belo Horizonte — MG, Brasil

 

 


SUMMARY

Mice experimentally infected with Schistosoma mansoni were injected with sodium thiopental or sodium antimonyl gluconate (Triostib R), or submitted to halothane inhalation, with or without a previous injection of thiopental.
Data obtained showed that halothane and thiopental induce worm shift to the liver (99 and 76%, respectively). Sodium gluconate and antimonium (Triostib R) shifted 52% of worms towards the liver.
These results seem to indicate that the use of antimonium would be unnecessary, when surgical removal of schistosomules is carried out through the extracorporeal filtration technique, in patients with portal hypertension.

Key words: Manson schistosomiasis — Experimental disease in mice — Antimonial drugs — Worm shift


RESUMO

Camundongos experimentalmente infectados com Schistosoma mansoni foram injetados com tiopental sódico ou antimonial (TriostibR), ou submetidos à inalação de halotano, com ou sem uma injeção prévia de tiopental. Os resultados mostraram que o halotano e o tiopental induzem, respectivamente, o deslocamento de 99 e 76% dos vermes para o fígado. Gluconato de sódio e antimonio (Triostib R) deslocou 52% de vermes. Estes resultados parecem indicar que o uso de antimonial seria desnecessário quando se faz a remoção cirúrgica de esquistossomos pela técnica de filtração extracorpórea em pacientes com hipertensão portal.


 

 

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

 

 

ACKNOWLEDGEMENTS

The authors are indebted to Mr. Alberto Geraldo dos Santos, Mrs. Alice Neni Parte Batista, and Miss Zenir de Souza for their technical assistance. They are also grateful to Mrs. Vera de Paula Ribeiro for her suggestions concerning the English text.

 

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Recebido para publicação em 26/9/1985

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