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Avaliação da resposta do Plasmodium falciparum à cloroquina, quinino e mefloquina

Evaluation of Plasmodium falciparum response to chloroquine, quinine and mefloquine

Resumos

Nosso estudo envolveu a análise de cepas de Plasmodium falciparum provenientes da Região Amazônica Brasileira, coletadas no Laboratório de Malária da SUCEN. Os estudos "in vitro" foram efetuados com a cloroquina (46 ensaios), quinino (42 ensaios) e mefloquina (51 ensaios). Os resultados mostraram resistência de 100% em relação à cloroquina, 2,4% ao quinino e 31,4% à mefloquina, na análise "in vitro". Sete pacientes foram tratados com quinino isolado e nove com a associação mefloquina + pirimetamina-sulfadoxina, não mostrando correlação com os testes "in vitro".

Terapêutica da malária; Microtestes de sensibilidade ao Plasmodium falciparum


The present study is concerned with the analysis of Plasmodium falciparum strains from the Brazilian Amazon Region, collected at the Malaria Laboratory - SUCENT. "In vitro" sensitivity tests were performed using chloroquine (46 samples), quinine (42 samples) and mefloquine (51 samples). Results have shown "in vitro" resistance to chloroquine in 100% of the tested samples, to quinine in 2.4% and to mefloquine in 3L4%. Seven patients were treated with quinine and nine with the triple combination (mefloquine plus sulfadoxine plus pyrimethamine). No correlation was shown between the therapeutic response and the "in vitro" tests.


ARTIGOS ORIGINAIS

Avaliação da resposta do Plasmodium falciparum à cloroquina, quinino e mefloquina(1 (1 ) Auxílio financeiro do CNPq-Polonoroeste 700349/85. )

Evaluation of Plasmodium falciparum response to chloroquine, quinine and mefloquine

S.M. Di Santi; V.L.F, Camargo Neves; M. Boulos; A.P. Dutra; A.M.S.V. Ramos; M. Santos; L.C.B. Barata

Laboratório de Malária da Superintendência de Controle de Endemias (SUCEN), Secretaria de Estado da Saúde do Estado de São Paulo. Rua Cardeal Arcoverde, 2878. CEP 05408 São Paulo, SP., Brasil

RESUMO

Nosso estudo envolveu a análise de cepas de Plasmodium falciparum provenientes da Região Amazônica Brasileira, coletadas no Laboratório de Malária da SUCEN. Os estudos "in vitro" foram efetuados com a cloroquina (46 ensaios), quinino (42 ensaios) e mefloquina (51 ensaios). Os resultados mostraram resistência de 100% em relação à cloroquina, 2,4% ao quinino e 31,4% à mefloquina, na análise "in vitro". Sete pacientes foram tratados com quinino isolado e nove com a associação mefloquina + pirimetamina-sulfadoxina, não mostrando correlação com os testes "in vitro".

Unitermos: Terapêutica da malária; Microtestes de sensibilidade ao Plasmodium falciparum.

SUMMARY

The present study is concerned with the analysis of Plasmodium falciparum strains from the Brazilian Amazon Region, collected at the Malaria Laboratory - SUCENT. "In vitro" sensitivity tests were performed using chloroquine (46 samples), quinine (42 samples) and mefloquine (51 samples). Results have shown "in vitro" resistance to chloroquine in 100% of the tested samples, to quinine in 2.4% and to mefloquine in 3L4%. Seven patients were treated with quinine and nine with the triple combination (mefloquine plus sulfadoxine plus pyrimethamine). No correlation was shown between the therapeutic response and the "in vitro" tests.

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  • (1
    ) Auxílio financeiro do CNPq-Polonoroeste 700349/85.
  • Datas de Publicação

    • Publicação nesta coleção
      17 Fev 2011
    • Data do Fascículo
      Jun 1988
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