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Revista do Instituto de Medicina Tropical de São Paulo

On-line version ISSN 1678-9946

Rev. Inst. Med. trop. S. Paulo vol.31 no.1 São Paulo Jan./Feb. 1989 



Inapparent lung involvement in patients with the subacute juvenile type of paracoccidioidomycosis


Compromiso pulmonar inaparente en la forma subagruda juvenil de la paracoccidioidomicosis



A. Restrepo; M. Trujillo; I. Gomez

Corporación para Investigaciones Biológicas (CIB), Hospital Pablo Tobón Uribe, Medellin, Colombia

Address for correspondence




Three patients with the diagnosis of subacute juvenile paracoccidioidomycosis who, at the time of their first visit, had no signs or symptoms of lung involvement, were studied. Initially the diagnosis was confirmed by the observation of P. brasiliensis in biopsy material obtained from clinically involved lymphadenopathies.
The lung X-rays done in all patients, did not reveal pathologic changes, although it was possible to observe and isolate the fungus from sputum samples obtained from the three patients. This fact reinforces the pulmonary genesis of the mycosis and proofs the existence of a pulmonary primary infection, even in patients with the juvenile manifestations, in whom the lung component is obscured by the predominant lymph node involvement.

Key words: Paracoccidioidomycosis; Primary pulmonary infection; Subclinical infection.


Se presentan las historias de 3 pacientes con el diagnóstico de paracoccidioidomicosis juvenil, en Jos cuales no se demonstraron signos ni sintomas de compromiso pulmonar al momento del diagnóstico. Tal diagnóstico fué inicialmente comprobado por la observación del P. brasiliensis en biopsias obtenidas de lesiones ganglionares clinicamente aparentes. Aunque las radiografias de torax no revelaron câmbios patológicos en ningún caso, fué posible observar y aislar el hongo de muestras de esputos obtenidas de los tres pacientes. Este hallazgo refuerza la hipótesis de la genesis pulmonar de la paracoccidioidomicosis y comprueba la existencia de una infección primária pulmonar aún en aquellos pacientes que presentan Ias manifestaciones de la forma juvenil y en quienes el componente pulmonar está disimulado por el gran compromiso de ganglios y órganos linfáticos.



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Address for correspondence:
Angela Restrepo, Ph.D
Corporación para Investigaciones Biológicas (CIB)
Hospital "Pablo Tobón Uribe"
Apartado Aéreo No. 73-78, Medellin, Colombia

Recebido para publicação em 8/6/1988.

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