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Revista do Instituto de Medicina Tropical de São Paulo

On-line version ISSN 1678-9946

Rev. Inst. Med. trop. S. Paulo vol.31 no.5 São Paulo Oct. 1989 



Measles vaccination: influence of age on its efficacy


Vacinação contra o sarampo: influência da idade em sua eficácia



Marta Heloísa LopesI; João Silva de MendonçaIII; Cláudio Sérgio PannutiI, IV; Paul AlbrechtII; Maria Lúcia Neves BiancalanaIII; Orlando César ManteseIII; José Fábio CorreaIII; Vicente Amato NetoI

IDepartamento de Doenças Infecciosas e Parasitárias - Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil
IIDivision of Virology - Center for Biologics Evaluation & Research Food and Drug Administration, Bethesda, Maryland, USA
IIIHospital do Servidor Público Estadual "Francisco Morato de Oliveira", São Paulo, SP, Brazil
IVLaboratório de Virologia - Instituto de Medicina Tropical de São Paulo, São Paulo, SP, Brazil

Address for correspondence




The authors compare the serologic efficacy and the clinical protection afforded by three different measles vaccination schemes in adequately nourished children in São Paulo city, Brazil.
Two hundred forty two children were divided into three groups. Group A, comprising 117 children who had received the vaccine before 12 months of age and a second dose at 12 months of age or more. Group B, comprising 46 children who had received only one dose, before 12 months of age. Group C, comprising 79 children who had received only one dose, at 12 months of age or more.
The geometric mean titer of antibodies in Group A was 790.1; in Group B, 251.1; and in Group C, 550.3. There was no statistically significant difference between Groups A and C.
The exposure to the measles virus was probably similar in all groups, and the children in Groups A and C had similar chances of acquiring the disease after vaccination whereas in Group B the chances were higher when compared to the other two groups.
The results obtained in this study favor the use, in developing countries, of a vaccination program against measles that includes an early first dose at eight months of age and revaccination after 12 months of age.

Key words: Measles vaccine; Measles; Children immunization.


Os autores comparam a eficácia sorológica e a proteção clinica obtidas com três esquemas diferentes de vacinação contra o sarampo, em crianças eutróficas, na cidade de São Paulo, Brasil.
Duzentas e quarenta e duas crianças foram divididas em três grupos. Grupo A, compreendendo 117 crianças primovacinadas antes dos 12 meses de idade e revacinadas com 12 ou mais meses de idade. Grupo B, compreendendo 46 crianças vacinadas com dose única, antes dos 12 meses de idade. Grupo C, compreendendo 79 crianças vacinadas com dose única, aos 12 ou mais meses de idade.
A média geométrica do título de anticorpos no grupo A foi 790,1; no grupo B, 251,1; e no grupo C, 550,3. Não houve diferença estatisticamente significante entre os grupos A e C.
A exposição ao vírus do sarampo foi provavelmente semelhante em todos os grupos. As crianças dos grupos A e C apresentaram risco de adoecimento semelhante após vacinação, enquanto que tal risco foi maior no grupo B quando comparado aos outros dois grupos.
Os resultados obtidos neste estudo falam a favor do uso, em países em desenvolvimento, de um programa de vacinação contra o sarampo que inclua uma primeira dose àos oito meses de idade e revacinação após os 12 meses de idade.



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Address for correspondence:
Marta Heloísa Lopes
Faculdade de Medicina da Universidade de São Paulo
Secretaria do Departamento de Doenças Infecciosas e Parasitárias
Av. Dr. Arnaldo, 455 - 2º andar - sala 99
01246 São Paulo, SP, Brazil

Recebido para publicação em 03/05/1989.

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