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Revista do Instituto de Medicina Tropical de São Paulo

On-line version ISSN 1678-9946

Rev. Inst. Med. trop. S. Paulo vol.32 no.1 São Paulo Jan./Feb. 1990

http://dx.doi.org/10.1590/S0036-46651990000100006 

EPIDEMIOLOGY

 

B and Delta hepatitis virus infection in a population of West Africa

 

Infecção pelo vírus da hepatite B e Delta em população da África Ocidental

 

 

N. ZanchettaI; P. ViganoII; M.P. FerrarioIII; G.B. PriuliIII; O. DjigbenoudeIII; G.P. NardiI; A. PaganoI

IInstitute of Hygiene, University Medical School, Milan, Italy
II2nd. Department of Infectious Diseases. L. Sacco Hospital, Milan, Italy
IIISt. Jean de Dieu Hospital. Tanguietà, R.P. Benin

Address for correspondence

 

 


SUMMARY

Among the 424 serum samples examined, the prevalence of hepatitis virus infection turned out to be 89.6%, with 15.6% of HBsAg positivity.
Some of the samples belonged to an afferent population and some other to workers of a West Africa rural hospital (Pop. Rep. of Benin). 27.3% of the positive subjects presented active replication of the virus, shown by the presence of HBeAg.
Among the HBcAb positive subjects the anti-delta antibodies showed a positivity frequency of 19.7%.
HBsAg presence in 15% of pregnant women suggested the importance of HBV mother-foetal transmission in the district.
The examined results can be compared with those obtained in other African areas, with similar socio-economic conditions.

Key words: B hepatitis; Delta hepatitis; West Africa.


RESUMO

Em 424 amostras de soros examinadas, a prevalência da infecção pelo vírus da hepatite B foi de 89,6% com 15,6% de posilividade para o HBsAg. Algumas das amostras pertenciam a uma população aferente e outras a pessoas trabalhando em hospital rural situado na África Ocidental (República Popular de Benin). 27,3% dos indivíduos soro-positivos evidenciaram replicação do vírus como demonstrado pela presença do HBeAg.
Nos indivíduos HBcAb positivos, os anticorpos anti-delta foram positivos em uma frequência de 19,7%.
A presença de HBsAg em 15% das mulheres gestantes eleva a importância da transmissão de HBV, da mãe para o filho, nesta região.
Os resultados apresentados podem ser comparados com aqueles obtidos em outras áreas da África, com condições sócio-econômicas semelhantes.


 

 

Full text available only in PDF format.

Texto completo disponível apenas em PDF.

 

 

ACKNOWLEDGMENTS

The Authors thank the Health Minister of R.P. Benin, Dr. A. Atchade and the Head of Tanguietà District Mr. C.S. Assani, for their encouragement and cooperation.

 

REFERENCES

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2. DERSO, A.; BOXALL, E.H.; TARLOW, M.J. & FEWETT, T.H. - Transmission of HBsAg from mother to infant in four ethnic groups. Brit. med. J., 1: 949-952, 1978.         [ Links ]

3. HANSONN, B.G.; MAESTRUP, T. & WIDELL, A. - Infection with delta agent in Sweden; introduction of a new hepatitis agent. J. Hepat., 1: 99-106, 1985.         [ Links ]

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9. TREPÒ, C.; BOUVET, B. & BERNARD, L. - Hepatitis virales: les agents responsables. Virus de l'hepalite B. Encyclopédie Médico-Chirurgicale, Foie-Pancreas, 7015-B30: 1-10, 1984.         [ Links ]

10. ZANETTI, A.R. & FERRONI, P. - Presence of HBeAg, DNA-polymerase activity, Dane particle in different categories of HBsAg carriers and evidence of hepatitis type B infection in their family contacts. Boll. Ist. sieroter. milan., 56: 79-84, 1977.         [ Links ]

 

 

Address for correspondence:
Dr. Nadia Zanchetta
Ospedale L. Sacco; Laboratorio di Microbiologia
Via G.B. Grassi 74
Milano, 20157, Italia (Italy)

Recebido para publicação em 08/06/1988.

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