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Revista do Instituto de Medicina Tropical de São Paulo

On-line version ISSN 1678-9946

Rev. Inst. Med. trop. S. Paulo vol.32 no.4 São Paulo July/Aug. 1990

http://dx.doi.org/10.1590/S0036-46651990000400012 

EXPERIMENTAL THERAPEUTIC ASSAYS

 

Pentavalent antimonial nephrotoxicity in the rat

 

Disfunção tubular renal em ratos tratados com antimoniais pentavalentes

 

 

Joel Paulo R. VeigaI; Rashida KhanamI; Tânia T. RosaI; Luiz F. Junqueira Jr.I; Plínio C. BrantI; Alberto N. RaickII; Horacio FriedmanII; Phillip D. MarsdenI

IDepartamento de Clínica Médica, Faculdade de Ciências da Saúde, Universidade de Brasília, Brasília, DF, Brasil
IIDepartamento de Patologia, Faculdade de Ciências da Saúde, Universidade de Brasília, Brasília, DF, Brasil

Address for correspondence

 

 


SUMMARY

Aspects of the renal function were assessed in rats treated with the pentavalent antimonials Glucantime (Meglumine Antimoniate, Rhodia) or Pentostam (Sodium Stibogluconate, Wellcome). In dose of 30 mg of Sbv (Glucantime or Pentostam) by 100 mg of weight by day for 30 days, renal functional changes were observed consisting of disturbances in urine concentrating capacity. Such disturbances were expressed by significantly low values of urine osmolality as compared to the basal values previous to the drugs. The decrease in urine osmolality was associated to a significant increase in urinary flow and in negative free-water clearance. There was no alteration in osmolar clearance and in fractional excretion of sodium. These observations suggest an interference of the drugs in the action of the antidiuretic hormone. The disturbance in urine concentration was reversible after a seven days period without the drugs administration. No significant histopathological alterations were observed in the kidneys of the rats treated with the drugs. On the other hand, the rats treated with a high dose of Pentostam (200 mg/100 grams of weight/day) showed the functional and the histopathological alterations of the acute tubular necrosis.

Key words: Pentavalent antimonial; Renal function; Urinary concentrating capacity; Acute tubular necrosis; Rat.


RESUMO

Estudou-se a função renal de ratos tratados com Glucantime (Antimoniato de Meglumine, Rhodia) e Pentostam (Estibogluconato de Sódio, Wellcome) na dose de 30 mg de Sbv por 100 g de peso por dia, durante 30 dias. Observou-se um distúrio na concentração urinária, que foi reversível 7 dias após cessada a administração das drogas. O estudo histopatológico do rim, por meio da microscopia óptica, não evidenciou alterações significativas. Por outro lado, ratos tratados com altas doses dos antimoniais (200 mg de Sbv por 100 g de peso por dia) mostraram alterações funcionais e histopatológicas renais compatíveis com necrose tubular aguda.


 

 

Full text available only in PDF format.

Texto completo disponível apenas em PDF.

 

 

ACKNOWLEDGMENTS

The authors are grateful to Fernando Vicente de Padua for their expert technical assistance.

 

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Address for correspondence:
Dr. Joel Paulo R. Veiga
Departamento de Clínica Médica, Faculdade de Ciências da Saúde, Universidade de Brasília
70910 Brasília, DF, Brasil

Recebido para publicação em 30/10/1989.
Research supported by CNPq (40.3789/82, 30.1524/85, 40.7383/85):

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