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Revista do Instituto de Medicina Tropical de São Paulo

On-line version ISSN 1678-9946

Rev. Inst. Med. trop. S. Paulo vol.34 no.5 São Paulo Sept./Oct. 1992

http://dx.doi.org/10.1590/S0036-46651992000500008 

EPIDEMIOLOGY

 

Associantion between leprosy and hepatitis B infecion. A survey in Goiânia, Central Brazil

 

Associação entre hanseniase e infecção pelo virus da hepatite B. Estudo de prevalência realizado em Goiânia, Brasil Central

 

 

Heitor RosaI; Ana Paula V.F. CostaII; Maria Lúcia FerrazIII; Suelene C. PedrozaII; Ana Lúcia S.S. AndradeIV; Celina M.T. MartelliIV; Fábio Zickerv

IUnity of Hepatology, Hospital das Clínicas/UFG, Goiânia, Brazil
IIResearch fellow
IIIEscola Paulista de Medicina/São Paulo, Brazil
IVInstituto de Patologia Tropical e Saúde Pública/UFG, Goiânia, Brazil
VOrganización Pan Americana de la Salud, Maracay-Venezuela

Address for Correspondence

 

 


SUMMARY

This investigation presents the results of Hepatitis B virus screening among leprosy patients conducted in Central Brazil as a preliminary information for a HBV vaccination programme. The main objectives were to assess the seroprevalence of HBV serum markers among lepromatous patients and to analyse institutionalization as risk factor for HBV infection in this population. Two groups of lepromatous patients were studied, 83 outpatients and 171 institutionalized ones. Screening for HBV serum markers included the detection of HBsAg, anti-HBc by radioimmune assay (RIA). The prevalence of carrier state (HBsAg) was 4.8% and 8.8% among outpatients and institutionalized, respectively, (p>0.05). Seroprevalence of exposure (all markers) was statistically significant different between outpatients (16.9%) and institutionalized ones (50.3%). Institutionalized patients had an almost four fold risk of HBV infection when compared to the outpatients, and the highest risks were among patients with more than 21 years of residence in the colony, after adjusting for age and sex.

Key words: Leprosy and Hepatitis B virus infection; Risk factors for Hepatitis B infection; Institutionalized leprosy patients.


RESUMO

Este estudo apresenta os resultados de investigação sorológica para o virus da hepatite B (VHB) entre pacientes hansenianos como etapa inicial para um programa de vacinação contra Hepatite B na cidade de Goiânia - Brasil Central. Os principais objetivos foram determinar a soroprevalência dos marcadores sorológicos para hepatite B entre pacientes com hanseníase do polo lepromatoso da doença, e avaliar a institucionalização como fator de risco para a infecção pelo VHB. Foram estudados 83 pacientes ambulatoriais e 171 pacientes institucionalizados e os marcadores testados foram AgHBs, anti-HBs e anti-HBc, utilizando-se a técnica de radioimuno ensaio. A prevalência de portadores virais (HBsAg) foi de 4,8% e 8,8% para os pacientes ambulatoriais e institucionalizados, respectivamente (P>0,05). A prevalência de exposição ao VHB (todos os marcadores) foi estatisticamente diferente entre os pacientes de ambulatório (16,9%) e os institucionalizados (50,5%). Os pacientes institucionalizados tiveram um risco 4 vezes maior de infecção pelo HBV quando comparados aos pacientes ambulatoriais, mesmo após análise multivariada, controlada por sexo e idade.


 

 

Full text available only in PDF format.

Texto completo disponível apenas em PDF.

 

 

ACKNOWLEDGEMENTS

We are grateful to Dr. H. Junqueira, Dr. I. S. Mondanez and Dr. R. M. Oliveira for their cooperation in the field work.

 

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Address for Correspondence:
Dr. Heitor Rosa, PhD
Rua 126 nº 21 apto 102
Setor Sul 74310 Goiânia-Brazil

Recebido para publicação em 9/1/1992
Aceito para publicação em 14/7/1992

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