Aplastic crisis due to human parvovirus B19 infection in hereditary hemolytic anaemia

Cubel, R. C. N.; Valadão, M. C.; Pereira, W. V.; Magalhães, M. C.; Nascimento, J. P.

doi:10.1590/S0036-46651992000500017

Abstracts

Specific anti-B19 IgM was demonstrated in sera from three children showing transient aplastic crisis. A two years-old boy living in Rio de Janeiro suffering from sickle-cell anaemia showed the crisis during August, 1990. Two siblings living in Santa Maria, RS, developed aplastic crisis during May, 1991, when they were also diagnosed for hereditary spherocytosis. For a third child from this same family, who first developed aplastic crisis no IgM anti-B19 was detected in her sera.

Human parvovirus B19; Transient aplastic crisis; Hereditary spherocytosis; Sickle-cell disease

IgM específica anti-B19 foi demonstrada nos soros de três crianças apresentando aplasia transitória de medula. Um menino de dois anos de idade vivendo no Rio de Janeiro e sendo portador de anemia falciforme, apresentou a crise durante Agosto de 1990. Dois irmãos vivendo em Santa Maria - RS, desenvolveram crise de aplasia em Maio de 1991, quando foram também diagnosticados como portadores de microesferocitose. IgM anti-B19 não foi detectada no soro de uma terceira criança, desta mesma família, a qual primeiramente apresentou crise de aplasia.

CASE REPORT

Aplastic crisis due to human parvovirus B19 infection in hereditary hemolytic anaemia

Crise aplástica devido à infecção por parvovirus humano B19 em anemia hemolítica hereditária

R. C. N. Cubel^I; M. C. Valadão^II; W. V. Pereira^II; M. C. Magalhães^III; J. P. Nascimento^I

^IDepartamento de Virologia, Instituto Oswaldo Cruz, FIOCRUZ, RJ

^IIServiço de Hematologia, Hosp. Universitário, UFSM, RS

^IIIServiço de Hematologia, Hosp. Gafrée-Guinle, UNIRIO, RJ

^{Correspondence to} Correspondence to : R. C. N. Cubel Dept. Virologia, FIOCRUZ Av. Brasil 4365,21045, Rio de Janeiro, Brasil

SUMMARY

Specific anti-B19 IgM was demonstrated in sera from three children showing transient aplastic crisis. A two years-old boy living in Rio de Janeiro suffering from sickle-cell anaemia showed the crisis during August, 1990. Two siblings living in Santa Maria, RS, developed aplastic crisis during May, 1991, when they were also diagnosed for hereditary spherocytosis. For a third child from this same family, who first developed aplastic crisis no IgM anti-B19 was detected in her sera.

Keywords: Human parvovirus B19; Transient aplastic crisis; Hereditary spherocytosis; Sickle-cell disease

RESUMO

IgM específica anti-B19 foi demonstrada nos soros de três crianças apresentando aplasia transitória de medula. Um menino de dois anos de idade vivendo no Rio de Janeiro e sendo portador de anemia falciforme, apresentou a crise durante Agosto de 1990. Dois irmãos vivendo em Santa Maria - RS, desenvolveram crise de aplasia em Maio de 1991, quando foram também diagnosticados como portadores de microesferocitose. IgM anti-B19 não foi detectada no soro de uma terceira criança, desta mesma família, a qual primeiramente apresentou crise de aplasia.

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ACKNOWLEDGMENT

We thanks Dr. M. J. Andrada-Serpa for her help in the preparation of this paper. R. C. N. Cubel is receiving a CNPq fellowship due to her PhD course at the Instituto de Microbiologia, UFRJ.

Recebido para publicação em 30/1/1992

Aceito para publicação em 4/5/1992

1. BERTRAND, Y.; LEFRERE, J.J.; LEVERGER, G.; COUROUCE, A.M.; FEO, C.; CLARK, M.; SHARSON, G. & SOULIER, J.P. - Autoimmune hemolytic anaemia revealed by human parvovirus linked erythroblastopenia. Lancet, 2: 382, 1985.
2. CRUZ , A.S.; ANDRADE-SERPA, M.J.; BARTH, O.M. & NASCIMENTO, J.P. - Detection of the human parvovirus B19 in a blood donor plasma in Rio de Janeiro. Mem. Inst. Oswaldo Cruz, 84: 279-280, 1989.
3. CUBEL, R.C.N. & NASCIMENTO, J.P. - Antibody capture enzyme immuno assays for the detection of IgM and IgG anti-human parvovirus B19. (in press).
4. DAVIS, L.R.; WHITE, J.M. & PATTISON, J.R. - Aplastic crisis in sickle cell disease and parvovirus. Brit. J. Haemat., 52: 135, 1982.
5. DUNCAN, J.R.; CAPPELLINI, M.D.; ANDERSON, M.J.; POTTER, C.G.; KURTZ, J.B. & WEATHERALL, D.J. - Aplastic crisis due to parvovirus infection in pyruvate kinase deficiency. Lancet, 2: 14-16, 1983.
6. FREITAS, R.B.; WONG, D.; BOSWELL, F.; MIRANDA, M.F.R.; LINHARES, A.C.; SHIRLEY, J. & DESSELBERGER, U. - Prevalence of human Parvovirus B19 and Rubellavirus infections in urban and remote rural areas in Northern Brazil. J. med. Virol., 32: 203-208, 1990.
7. FRICKHOFEN, N.; RAGHACACHAR, A.; HEIT, W.; HEIMPEL, H. & COHEN, B.J. - Human parvovirus infection. New Eng. J. Med., 314: 646, 1986.
8. KELLEHER, J.F. Jr.; LUBAN, N.L.C.; MORTIMER, P.P. & KAMIURA, T. - Human serum parvovirus: a specific cause of aplastic crisis in children with hereditary spherocytosis. J. Pediat., 152: 720-722, 1983.
9. LEFRERE, J.J.; COUROUCE, A.M.; BERTRAND, Y.; GIROT, R. & SOULIER, J.P. - Human parvorirus and aplastic crisis in chronic hemolitic anemias: a study of 24 observations. Amer. J. Hemat., 23: 271-275, 1986.
10. MIRANDA, M.F.R.; LINHARES, A.C. & SHIRLEY, J.A. - Fifth disease in children living in Belém, Brazil. Rev. Inst. Med. trop. S. Paulo, 31: 359-362, 1989.
11. MORI, J.; FIELD, A.M.; CLEWLEY, J.P. & COHEN, B.J. - Dot blot hybridization assay of B19 virus DNA in clinical specimens J. clin. Microbiol., 27: 459-464, 1989.
12. MORTIMER, P.P.; HUMPHRIES, R.K; MOORE, J.G.; PURCELL, R.H. & YOUNG, N.S. - A human parvovirus-like virus inhibits haemopoietic colony formation in vitro. Nature, 302: 426-429, 1983.
13. NASCIMENTO, J.P.; BUCKLEY, M.M.; BROWN, K.E. & COHEN, B.J. - The prevalence of antibody to human parvovirus B19 in Rio de Janeiro, Brazil. Rev. Inst. Med. trop. S. Paulo, 32: 41-45, 1990.
14. NASCIMENTO, J.P.; PEGADO, C.S. & GARCIA, A.P. - B19 infection and hydrops fetalis in Rio de Janeiro, Brazil. In: INTERNATIONAL CONGRESS OF VIROLOGY, 8, Berlim, 1990. Abstracts. p. 240
15. PATTISON, J.R. - Diseases caused by the human parvovirus B19. Arch. Dis. Child., 63: 1426-1427, 1988.
16. PATTISON, J.R.; JONES, S.E.; HODGSON, J.; DAVIS, L.R.; WHITE, J.M.; STROUD, C.E. & MURTAZA, L. - Parvovirus infections and hypoplastic crisis in sickle cell anaemia. Lancet, 1: 664-665, 1981.
17. RAO, K.R.P.; PATEL, A.R. & ANDERSON, M.J. - Infection with parvovirus like virus and aplastic crisis in chronic hemolytic anemia. Ann. intern. Med., 98: 930-932, 1983.
18. SEARGENT, G.R.; MASON, K.; TOPLEY, J.M.; SEARGENT, B.E.; PATTISON, J.R.; JONES, S.E. & MOHAMED, R. - Outbreak of aplastic crisis in sickle cell anemia associated with parvovirus like agent. Lancet, 2: 595-597, 1981.
19. SAUNDERS, P.W.G.; REID, M.M. & COHEN, B.J. - Human parvovirus induced cytopenias: a report of five cases. Brit. J. Haemat., 63: 407-410, 1986.
20. YOUNG, N.S. - Hematologic and hematopoietic consequences of B19 parvovirus infection. Semin. Hemat., 25: 159-172, 1988.

Correspondence to

:

R. C. N. Cubel

Dept. Virologia, FIOCRUZ

Av. Brasil 4365,21045, Rio de Janeiro, Brasil

Publication Dates

Publication in this collection
13 Sept 2006
Date of issue
Oct 1992

History

Received
30 Jan 1992
Accepted
04 May 1992

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. BERTRAND, Y.; LEFRERE, J.J.; LEVERGER, G.; COUROUCE, A.M.; FEO, C.; CLARK, M.; SHARSON, G. & SOULIER, J.P. - Autoimmune hemolytic anaemia revealed by human parvovirus linked erythroblastopenia. Lancet, 2: 382, 1985.

[2] 2. CRUZ , A.S.; ANDRADE-SERPA, M.J.; BARTH, O.M. & NASCIMENTO, J.P. - Detection of the human parvovirus B19 in a blood donor plasma in Rio de Janeiro. Mem. Inst. Oswaldo Cruz, 84: 279-280, 1989.

[3] 3. CUBEL, R.C.N. & NASCIMENTO, J.P. - Antibody capture enzyme immuno assays for the detection of IgM and IgG anti-human parvovirus B19. (in press).

[4] 4. DAVIS, L.R.; WHITE, J.M. & PATTISON, J.R. - Aplastic crisis in sickle cell disease and parvovirus. Brit. J. Haemat., 52: 135, 1982.

[5] 5. DUNCAN, J.R.; CAPPELLINI, M.D.; ANDERSON, M.J.; POTTER, C.G.; KURTZ, J.B. & WEATHERALL, D.J. - Aplastic crisis due to parvovirus infection in pyruvate kinase deficiency. Lancet, 2: 14-16, 1983.

[6] 6. FREITAS, R.B.; WONG, D.; BOSWELL, F.; MIRANDA, M.F.R.; LINHARES, A.C.; SHIRLEY, J. & DESSELBERGER, U. - Prevalence of human Parvovirus B19 and Rubellavirus infections in urban and remote rural areas in Northern Brazil. J. med. Virol., 32: 203-208, 1990.

[7] 7. FRICKHOFEN, N.; RAGHACACHAR, A.; HEIT, W.; HEIMPEL, H. & COHEN, B.J. - Human parvovirus infection. New Eng. J. Med., 314: 646, 1986.

[8] 8. KELLEHER, J.F. Jr.; LUBAN, N.L.C.; MORTIMER, P.P. & KAMIURA, T. - Human serum parvovirus: a specific cause of aplastic crisis in children with hereditary spherocytosis. J. Pediat., 152: 720-722, 1983.

[9] 9. LEFRERE, J.J.; COUROUCE, A.M.; BERTRAND, Y.; GIROT, R. & SOULIER, J.P. - Human parvorirus and aplastic crisis in chronic hemolitic anemias: a study of 24 observations. Amer. J. Hemat., 23: 271-275, 1986.

[10] 10. MIRANDA, M.F.R.; LINHARES, A.C. & SHIRLEY, J.A. - Fifth disease in children living in Belém, Brazil. Rev. Inst. Med. trop. S. Paulo, 31: 359-362, 1989.

[11] 11. MORI, J.; FIELD, A.M.; CLEWLEY, J.P. & COHEN, B.J. - Dot blot hybridization assay of B19 virus DNA in clinical specimens J. clin. Microbiol., 27: 459-464, 1989.

[12] 12. MORTIMER, P.P.; HUMPHRIES, R.K; MOORE, J.G.; PURCELL, R.H. & YOUNG, N.S. - A human parvovirus-like virus inhibits haemopoietic colony formation in vitro. Nature, 302: 426-429, 1983.

[13] 13. NASCIMENTO, J.P.; BUCKLEY, M.M.; BROWN, K.E. & COHEN, B.J. - The prevalence of antibody to human parvovirus B19 in Rio de Janeiro, Brazil. Rev. Inst. Med. trop. S. Paulo, 32: 41-45, 1990.

[14] 14. NASCIMENTO, J.P.; PEGADO, C.S. & GARCIA, A.P. - B19 infection and hydrops fetalis in Rio de Janeiro, Brazil. In: INTERNATIONAL CONGRESS OF VIROLOGY, 8, Berlim, 1990. Abstracts. p. 240

[15] 15. PATTISON, J.R. - Diseases caused by the human parvovirus B19. Arch. Dis. Child., 63: 1426-1427, 1988.

[16] 16. PATTISON, J.R.; JONES, S.E.; HODGSON, J.; DAVIS, L.R.; WHITE, J.M.; STROUD, C.E. & MURTAZA, L. - Parvovirus infections and hypoplastic crisis in sickle cell anaemia. Lancet, 1: 664-665, 1981.

[17] 17. RAO, K.R.P.; PATEL, A.R. & ANDERSON, M.J. - Infection with parvovirus like virus and aplastic crisis in chronic hemolytic anemia. Ann. intern. Med., 98: 930-932, 1983.

[18] 18. SEARGENT, G.R.; MASON, K.; TOPLEY, J.M.; SEARGENT, B.E.; PATTISON, J.R.; JONES, S.E. & MOHAMED, R. - Outbreak of aplastic crisis in sickle cell anemia associated with parvovirus like agent. Lancet, 2: 595-597, 1981.

[19] 19. SAUNDERS, P.W.G.; REID, M.M. & COHEN, B.J. - Human parvovirus induced cytopenias: a report of five cases. Brit. J. Haemat., 63: 407-410, 1986.

[20] 20. YOUNG, N.S. - Hematologic and hematopoietic consequences of B19 parvovirus infection. Semin. Hemat., 25: 159-172, 1988.