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Revista do Instituto de Medicina Tropical de São Paulo

On-line version ISSN 1678-9946

Rev. Inst. Med. trop. S. Paulo vol.35 no.3 São Paulo May/June 1993

http://dx.doi.org/10.1590/S0036-46651993000300012 

THERAPEUTIC ASSAY

 

Effect of oxamniquine on cell adhesion to Schistosoma mansoni larvae in the peritoneal cavity of naive mice

 

Efeito da oxamniquina sobre a adesão celular da larva do S. mansoni na cavidade peritoneal de camundongos

 

 

Alan Lane de Melo; Leógenes Horácio PereiraI

IDepartamento de Parasitologia Instituto de Ciências Biológicas da UFMG, CP 2486, CEP 30161-970, Belo Horizonte, Minas Gerais, Brasil

 

 


SUMMARY

The treatment of naive mice with high closes of oxamniquine, 1 hour before the intraperitoneal inoculation of Schistosoma mansoni cercariae, induces a delay in the transformation process resulting in a longer host cell adhesion.

Key words: Schistosoma mansoni; Cell adhesion; Cercaria; Schistosomulum; Oxamniquine.


RESUMO

O tratamento de camundongos sem infecção prévia com altas doses de oxamniquina, 1 hora antes do inóculo intraperitoneal com cercárias de Schistosoma mansoni, induz a um atraso no processo de transformação, resultando conseqüentemente em larvas com adesão celular mais duradoura.


 

 

Full text available only in PDF format.

Texto completo disponível apenas em PDF.

 

 

REFERENCES

1. COUSIN, C.C.; STIREWALT, M.A.; DORSEY, C.H. & WATSON, O.L.P. - Schistosoma mansoni: comparative development of schistosomules produced by artificial techniques. J. Parasit., 72: 606-609, 1986.         [ Links ]

2. CRAM, E.B. & BOZICEVICH, J. - Experimental Schistosoma mansoni infection by intraperitoneal injection. Trop. Med. News, 1: 16-17, 1944.         [ Links ]

3. EVELAND, L.K. - Schistosoma mansoni: conversion of cercariae to schistosomula. Exp. Parasit., 32: 261-264, 1972.         [ Links ]

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7. MELO, A.L. & PEREIRA, L.H. - Kinetics of the cercaria-shistosomulum transformation, in vivo: 2- The effect of oxaniniquine. Rev. Soc. bras. Med. trop., 18: 251-255, 1985.         [ Links ]

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10. PELLEGRINO, J. & MACEDO, D.G. - A simplified method for the concentration of cercariae. J. Parasit., 41: 329-330, 1955.         [ Links ]

11. PEREIRA, L.H.; PELLEGRINO, J.; VALADARES, T.E.; MELLO, R.T. & COELHO, P.M.Z. - A new approach for screening prophylactic agents in schistosomiasis. Rev. Inst. Med. trop. S. Paulo, 16: 123-126, 1974.         [ Links ]

12. SAMUELSON, J.C.; SHER, A. & CAULFIELD, J.P. - Newly transformed schistosomula spontaneously lose surface antigens and C3 aceptor sites during culture. J. Immunol., 124: 2055-2057, 1980.         [ Links ]

13. STIREWALT, M.A. - Schistosoma mansoni: cercaria to schistosomule. Advanc. Parasit., 12: 115-182, 1974.         [ Links ]

14. YOLLES, T.K.; MOORE, D.V. & MELENEY, H.E. - Post cercarial development of Schistosoma mansoni in the rabil and hamster after intraperitoneal and percutaneous infection. J. Parasit., 35: 276-294, 1949.         [ Links ]

 

 

Recebido para publicação em 11/08/1992
Aceito para publicação em 06/10/1992
Supported by The Parasitic Diseases Programme - WHO, Switzerland, CNPq, FINEP, and FAPEMIG, Brazil.

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