Effect of oxamniquine on cell adhesion to Schistosoma mansoni larvae in the peritoneal cavity of naive mice

Efeito da oxamniquina sobre a adesão celular da larva do S. mansoni na cavidade peritoneal de camundongos

THERAPEUTIC ASSAY

Effect of oxamniquine on cell adhesion to Schistosoma mansoni larvae in the peritoneal cavity of naive mice

Efeito da oxamniquina sobre a adesão celular da larva do S. mansoni na cavidade peritoneal de camundongos

Alan Lane de Melo; Leógenes Horácio Pereira^I

^IDepartamento de Parasitologia Instituto de Ciências Biológicas da UFMG, CP 2486, CEP 30161-970, Belo Horizonte, Minas Gerais, Brasil

SUMMARY

The treatment of naive mice with high closes of oxamniquine, 1 hour before the intraperitoneal inoculation of Schistosoma mansoni cercariae, induces a delay in the transformation process resulting in a longer host cell adhesion.

Key words:Schistosoma mansoni; Cell adhesion; Cercaria; Schistosomulum; Oxamniquine.

RESUMO

O tratamento de camundongos sem infecção prévia com altas doses de oxamniquina, 1 hora antes do inóculo intraperitoneal com cercárias de Schistosoma mansoni, induz a um atraso no processo de transformação, resultando conseqüentemente em larvas com adesão celular mais duradoura.

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Recebido para publicação em 11/08/1992

Aceito para publicação em 06/10/1992

Supported by The Parasitic Diseases Programme - WHO, Switzerland, CNPq, FINEP, and FAPEMIG, Brazil.

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Publication Dates

• Publication in this collection
  20 July 2006
• Date of issue
  June 1993

History

• Accepted
  06 Oct 1992
• Received
  11 Aug 1992