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Revista do Instituto de Medicina Tropical de São Paulo

On-line version ISSN 1678-9946

Rev. Inst. Med. trop. S. Paulo vol.36 no.6 São Paulo Nov./Dec. 1994

http://dx.doi.org/10.1590/S0036-46651994000600009 

IMMUNOLOGY

 

Usefulness of the detection of Toxoplasma gondii antigens in AIDS patients

 

Utilidad de la detección de antígenos de Toxoplasma gondii en pacientes con SIDA

 

 

Alberto Fachado; Luis Fonte; Esteban Alberti; Pablo Hadad; Lisset Fonseca; Rodolfo Machin; Carlos Finlay

Department of Parasitology, Institute of Tropical Medicine "Pedro Kouri", Havana City, Cuba

Correspondence to

 

 


SUMMARY

Toxoplasmic encephalitis (TE) is a mayor cause of central nervous system infection in patients with acquired immunodeficiency syndrome (AIDS). Toxoplasma antibodies were detected in 56 of 79 patients with AIDS (71%), in the present study. Fourteen out of 57 seropositive patients developed TF (25%) and had Toxoplasma gondii antigen detected in their urine. For this, most of them received an effective therapy, with the subsequent disappearance of the symptoms and discontinuity of excretion of the T. gondii antigens.
Our results suggest that the monitoring of T. gondii antigen in the urine of AIDS patients may be useful to decide on the proper time for therapy, as well as to avoid the beginning of neurologic signs in these patients.

Keywords: T. gondii; toxoplasmic encephalitis; AIDS.


RESUMEN

La Encefalitis Toxoplásmica (ET) es la más importante complicación infecciosa del Sistema Nervioso Central en pacientes de SIDA. Anticuerpos anti-Toxoplasma gondii fueron detectados en 57 de 79 pacientes de SIDA (71%). De estos seropositivos, desarrollaron la enfermedad (ET) 14 (25%), en los que coincidentemente se detectó la presencia de antígeno del parásito en orina y por tanto fueron objeto de una terapia efectiva, con la subsecuente desaparición de los sintomas y de los antígenos excretados. Por los resultados del presente trabajo, consideramos lo útil de monitorear en estos pacientes la presencia de antígenos de T. gondii con el objetivo de aplicar oportunamente métodos quimoprofilácticos que eviten el surgimiento de manifestaciones neurológicas en estos pacientes.


 

Full text available only in PDF format.

Texto completo disponible sólo en PDF.

 

ACKNOWLEDGEMENTS

We would like to thank doctors Rafael Martínez, Imirse Fraga and Carlos Millán for their valuable professional support for the realization of this paper.

 

REFERENCES

1. CDC - Classification system for human T-lymphotropic virus type III/ lymphadenopathy-associated virus infections. M.M.W.R., 35: 334-339, 1986.         [ Links ]

2. DARCY, F.; FOUDRINIER, F.; MOUGEOT, G. et al. - Diagnostic value of specific IgA antibodies in AIDS patients with Toxoplasma infection: a bicentric evaluation. Immunol. Lett., 30: 345-348, 1991.         [ Links ]

3. DE CLERCQ, D.; HENRY, M.C. & LOKOMBE, B. - Serological observations on toxoplasmosis in Zairian AIDS patients. Trans. roy. Soc. trop. Med. Hyg., 80: 613-614, 1986.         [ Links ]

4. DEROUIN, F.; BEAUVAIS, B. & LARIVIERE, M. - Serological study of the prevalence of toxoplasmosis in 167 patients with acquired immunodeficiency syndrome (AIDS) or chronic lymphadenopathy syndrome (LAS). Biomed. Pharmacother., 40: 231-232, 1986.         [ Links ]

5. FACHADO, A.; FONTE, L.; ROJAS, L.; ALBERTI, E. & MACHIN, R. - Technique for the detection of Toxoplasma gondii antigens in mouse urine. Mem. Inst. Oswaldo Cruz, 85: 65-68, 1990.         [ Links ]

6. FACHADO, A.; FONTE, L.; ALVAREZ, A.; ALBERTI, E. & FINLAY, C. - Antigens of Toxoplasma gondii in a patient urine detected by coagglutination. Mem. Inst. Oswaldo Cruz, 87: 303-304, 1992.         [ Links ]

7. GARIN, J.P. - Traitement et Prophylaxis de la Toxoplasmose. Rev. Méd. (Paris), 9: 491-498, 1971.         [ Links ]

8. GRANT, I.H.; GOLD, J.W.M.; ROSENBLUM, M.; WIEDZIECKI, D. & ARMSTRONG, P.A. - Toxoplasma gondii serology in HIV infected patients: the development of central nervous system toxoplasmosis in AIDS. AIDS, 4: 519-521, 1990.         [ Links ]

9. HASSL, A.; ASPOCK, M.H. & FLAMM, H. - Circulating antigen of Toxoplasma gondii in patients with AIDS: significance of detection and structural properties. Zbl. Bakt. Hyg., 270: 302-309, 1988.         [ Links ]

10. HASSL, A. & ASPOCK, H. - Antigens of Toxoplasma gondii recognized by sera of AIDS patients before, during, and after clinically important infection. Zbl. Bakt. Hyg., 272: 514-525, 1990.         [ Links ]

11. LEVY, R.M.; BREDESEN, D.E. & ROSENBLUM, M.L. - Neurological manifestations of the acquired immunodeficiency syndrome (AIDS): experience at UCSF and review of the literature. J. Neurosurg., 62: 475-495, 1985.         [ Links ]

12. LOWRY, O.H.; ROSEBROUGH, N.J.; FARR, A.L. & RANDALL, R.J. - Protein measurement with the Folin phenol reagent. J. biol. Chem., 193: 265-275, 1951.         [ Links ]

13. LUFT, B.J. & REMINGTON, J.S. - Toxoplasmic Encephalitis. J. infect. Dis., 157: 1-6, 1988.         [ Links ]

14. MACHIN, R.; DE LA CRUZ, F. & PIVIDAL, J. - Comparación del ELISA con las técnicas de Inmunofluorescencia indirecta y fijación del complemento para el diagnóstico de la toxoplasmosis. Rev. cub. Med. trop., 37: 269-277, 1985.         [ Links ]

15. MC CABE, R. & REMINGTON, J.S. - Toxoplasmosis: the time has come. New Engl. J. Med., 318: 313-315, 1988.         [ Links ]

16. MILIS, L. - Pneumocystis carini and Toxoplasma gondii infections in patients with AIDS. Rev. infect. Dis., 8: 1001-1011, 1986.         [ Links ]

17. POTASMAN, I.; RESNICK, L.; LUFT, B.J. & REMINGTON, J.S. - Intrathecal production of antibodies against Toxoplasma gondii in patients with toxoplasmic encephalitis and acquired immunodeficiency syndrome (AIDS). Ann. intern. Med., 108: 49-51, 1988.         [ Links ]

18. VAN KNAPEN, F. & PANGGABEAN, S.O. - Detection of circulating antigen during acute infections Toxoplasma gondii by enzyme linked immunosorbent assay. J. clin. Microbiol., 6: 545-547, 1977.         [ Links ]

19. ZUMLA, D.; SAVVA, D.; WHEELER, R.B. et al. - Toxoplasma serology in Zambia and Uganda patients infected with the human immunodeficiency virus. Trans. roy. Soc. trop. Med. Hyg., 85: 227-229, 1991.         [ Links ]

 

 

Correspondence to:
Lic. Alberto Fachado
Departamento de Parasitologia, Instituto de Medicina Tropical "Pedro Kouri"
Autopista Novia del Mediodia Km 6 e/ Autopista Nacional y Carretera Central (N/251)
Lisa-Habana-Cuba

Recebido para publicação em 14/06/1993.
Aceito para publicação em 19/08/1994.

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