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Revista do Instituto de Medicina Tropical de São Paulo

On-line version ISSN 1678-9946

Rev. Inst. Med. trop. S. Paulo vol.37 no.1 São Paulo Jan./Feb. 1995

http://dx.doi.org/10.1590/S0036-46651995000100012 

EPIDEMIOLOGY

 

High prevalence of hepatitis C infection among Brazilian hemodialysis patients in Rio de Janeiro: a one-year follow-up study

 

Alta prevalência de infecção pelo virus da hepatite C em pacientes de hemodiálise do Rio de Janeiro: estudo de acompanhamento durante 1 ano

 

 

B. O. M. VanderborghtI,II; C. RouzereI,II; C. F. GinuinoII; G. MaertensI; H. Van HeuverswynI; C. F. T. YoshidaII

IInnogenetics N.V., Ghent, Belgium
IIDepartment of Virology, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil

Correspondence to

 

 


SUMMARY

Nearly 400 hemodialysis patients treated at 5 different hemodialysis units in Rio de Janeiro were tested for one year for the presence of hepatitis C and B markers. During the same period, samples were also obtained from 35 continuous ambulatory peritoneal dialysis (CAPD) patients and from 242 health care workers. Depending on the hemodialysis unit studied, anti-HCV prevalence rates ranging from 47% to 82% (mean 65%) were detected. CAPD patients showed a lower prevalence of 17%. The prevalence of antibodies against hepatitis C virus (anti-HCV) among health care workers was 2.9%. We observed a hepatitis C attack rate of 11.5% per year in the anti-HCV-negative hemodialysis patient population. An average of 9.4% of the hemodialysis patients were chronic carriers of hepatitis B virus (HBV) (range 1.8% - 20.4%), while 48.9% showed markers of previous HBV infection. The HBV attack rate was 4.5% per year (range 0% - 6%). These results indicate an alarming high prevalence of anti-HCV among hemodialysis patients of this studied region.

Keywords: Hemodialysis; CAPD, Health care workers; Hepatitis C virus; Hepatitis B virus; Hepatitis C transmission; Brazil.


RESUMO

Aproximadamente 400 pacientes de hemodiálise tratados em 5 diferentes unidades no Rio de Janeiro foram acompanhados durante 1 ano para presença de marcadores virais de hepatite B e C. Durante o mesmo período, amostras foram também de 35 pacientes ambulatoriais de diálise peritonial contínua (CAPD) e de 242 funcionários das unidades. Dependendo da unidade em estudo foram detectadas prevalências de anti-HCV variando de 47% a 82% (média 65%). Pacientes de CAPD demonstraram uma baixa prevalência de 17%. A prevalência de anti-HCV em funcionários foi de 2.9%. Observamos uma taxa de ataque de hepatite C de 11.5% por ano na população paciente de hemodiálise anti-HCV-negativo. Uma média de 9.4% de pacientes de hemodiálise eram portadores crônicos do vírus da hepatite B (VHB) (taxa de 1.8% a 20.4%), enquanto 48.9% apresentaram marcadores de infecção passada de HBV. A taxa de ataque de HBV foi de 4.5% por ano (taxa de 0% a 6%). Esses resultados indicam uma alarmante prevalência alta de anti-HCV em pacientes de hemodiálise dessa região estudada.


 

 

Full text available only in PDF format.

Texto completo disponível apenas em PDF.

 

 

ACKNOWLEDGEMENTS

The authors thank Lucy Dalva de Almeida and Felipe Loponte Saback for their excellent technical assistance, and Fred Shapiro for manuscript editing.

 

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Correspondence to:
B. Vanderborght
Fundação Oswaldo Cruz, Dep. de Virologia
Av. Brasil 4365
21040-360 Rio de Janeiro, RJ, Brasil
Phone and Fax:+ 55 21 270 63 97

Recebido para publicação em 06/05/1994.
Aceito para publicação em 25/08/1994.

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