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Revista do Instituto de Medicina Tropical de São Paulo

On-line version ISSN 1678-9946

Rev. Inst. Med. trop. S. Paulo vol.37 no.6 São Paulo Nov./Dec. 1995

http://dx.doi.org/10.1590/S0036-46651995000600003 

VIROLOGY

 

Association of human herpesvirus 6 infection with exanthem subitum in Belem, Brazil

 

Exantema súbito associado a infecção pelo herpesvírus humano tipo 6 em Belém, Brasil

 

 

R. B. de FreitasI; A. C. LinharesI; C. S. OliveiraI; R. H. P. GusmãoI; M. I. S. LinharesII

IServiço de Virologia Geral, Instituto Evandro Chagas, Fundação Nacional de Saúde, Ministério da Saúde, Belém, Pará, Brasil
IIInstituto de Imunopatologia Keizo Asami, Universidade Federal de Pernambuco, Ministério da Educação, Recife, Pernambuco, Brasil

Correspondence to

 

 


SUMMARY

Recent human herpesvirus 6 (HHV-6) infection was detected in cases of exanthem subitum (ES) involving four children, aged 10 to 24 months, between April and August 1994, in Belém, Brazil. By using the indirect immunofluorescence antibody assay (IFA), significant increases (at least eight times) in antibody concentrations were noted from the acute to the convalescent serum samples, with titers ranging from <1:10/1:80 to <1:10/1:640 (patients 3 and 2, respectively). All children had high fever (over 39ºC) for three days, followed by generalized, maculo-papular skin rash. A physical examination of the children also revealed concomitant, cervical lymph node swelling and tonsillar pharyngitis in two of them.

Keywords: Human herpesvirus 6; Exanthem subitum.


RESUMO

Infecção recente por herpesvírus humano tipo 6 (HHV-6) foi detectada em casos de exantema súbito envolvendo quatro crianças com idades de 10 a 24 meses, no período compreendido entre abril e agosto de 1994, em Belém, Brasil. Utilizando-se a técnica da imunofluorescência indireta, aumentos significativos (de pelo menos oito vezes) foram observados nas concentrações de anticorpos das amostras de soro, da fase aguda para as da convalescente, com títulos variando de < 1:10 / 1:80 a < 1:10 / 1:640 (pacientes 3 e 2, respectivamente). Todas as crianças apresentaram febre alta (acima de 39ºC) por três dias, seguida de exantema máculo-papular generalizado. O exame físico realizado nas crianças revelou concomitância de adenomegalia cervical e amigdalite em dois desses indivíduos.


 

 

Full text available only in PDF format.

Texto completo disponível apenas em PDF.

 

 

ACKNOWLEDGEMENTS

We thank Drs. Elisabete C. O. Santos, Amélia P. A. Travassos da Rosa and Sebastião Aldo Valente for performing the rubella/measles, arbovirus and toxoplasmosis diagnoses, respectively. Thanks are also due to Dr. Ralph Lainson for kindly reviewing the manuscript.

 

REFERENCES

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Correspondence to:
Dr. Ronaldo B. de Freitas
Instituto Evandro Chagas
Avenida Almirante Barroso, 492
66090-000, Belém, Pará, Brasil

Recebido para publicação em 24/05/1995.
Aceito para publicação em 08/08/1995.

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