Abstract
Thirty eight paralysis cases classified as Guillain-Barré syndrome (GBS) in Brazil were analysed. In all these cases Sabin-related poliovirus vaccine strains were isolated. In most of the cases the last vaccine dose was given months or years before the onset of GBS, suggesting a persistent infection or the transmission of the Sabin-related strains to the patients. The isolation of Sabin-related strains from GBS cases some days or weeks after the onset of the disease, demonstrated a temporal association between the isolation of the strains and the disease. Although the isolates from the GBS cases may not be the etiological agent of the disease, this study strongly indicates that infections caused by Sabin-related vaccine strains can trigger the GBS in certain cases.
Sabin vaccine; Poliovirus; Guillain-Barré syndrome; vaccine-associated
BRIEF COMMUNICATION
Temporal association between the isolation of Sabin-related poliovirus vaccine strains and the Guillain-Barré syndrome
F. Friedrich; A. M. B. Filippis; H. G. Schatzmayr
Correspondence to Correspondence to: Fabian Friedrich Departamento de Virologia, Instituto Oswaldo Cruz, FIOCRUZ 21040-360 Rio de Janeiro, RJ, Brasil Phone and FAX: 00 55 21 270 6397
SUMMARY
Thirty eight paralysis cases classified as Guillain-Barré syndrome (GBS) in Brazil were analysed. In all these cases Sabin-related poliovirus vaccine strains were isolated. In most of the cases the last vaccine dose was given months or years before the onset of GBS, suggesting a persistent infection or the transmission of the Sabin-related strains to the patients. The isolation of Sabin-related strains from GBS cases some days or weeks after the onset of the disease, demonstrated a temporal association between the isolation of the strains and the disease. Although the isolates from the GBS cases may not be the etiological agent of the disease, this study strongly indicates that infections caused by Sabin-related vaccine strains can trigger the GBS in certain cases.
Keywords: Sabin vaccine; Poliovirus; Guillain-Barré syndrome - vaccine-associated.
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ACKNOWLEDGEMENTS
We thank the epidemiologists (Polio Group) of the Health Ministry of Brazil for the very useful informations about the patients.
Recebido para publicação em 24/10/1995.
Aceito para publicação em 11/12/1995.
This work was supported by the Expanded Program on Immunization, Pan American Health Organization, and also by CNPq and Capes.
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Publication Dates
-
Publication in this collection
22 Sept 2006 -
Date of issue
Feb 1996
History
-
Accepted
11 Dec 1995 -
Received
24 Oct 1995