Gastrointestinal translocation as a possible source of candidemia in an AIDS patient

Translocação gastrointestinal como possível fonte de fungemia em paciente portador de AIDS

MICOLOGY

Gastrointestinal translocation as a possible source of candidemia in an AIDS patient

Translocação gastrointestinal como possível fonte de fungemia em paciente portador de AIDS

Arnaldo Lopes Colombo^I; Maria Luiza Branchini^III; Débora Geiger^II; Ana Lucia Schimidt^I; Antonio Carlos Campos Pignatari^I; Olga Fischman^II

^IDivision of Infectious Diseases from Escola Paulista de Medicina - Universidade Federal de São Paulo, São Paulo, SP, Brazil

^IIDivision of Celular Biology from Escola Paulista de Medicina - Universidade Federal de São Paulo, São Paulo, SP, Brazil

^IIIDivision of Infectious Diseases from Faculdade de Ciências Médicas - Universidade de Campinas, Campinas, SP, Brazil

^{Correspondence to}

SUMMARY

Apart from cryptococcosis and histoplasmosis, which are mycoses contained by T cell-mediated mechanisms of host defense, fungemia is rarely found in AIDS patients. The frequency of fungemia due to Candida spp. has been reported to be as low as 1 %. We report a non-neutropenic AIDS patient who presented a candidemia which probably arose from her gastrointestinal tract.

Keywords: Fungemia; AIDS; Candidiasis.

RESUMO

Diferente de histoplasmose e criptococose, doenças fúngicas associadas a depressão da imunidade celular, fungemia causada por Candida spp. tem sido raramente relatada em pacientes com AIDS. O presente relato ilustra um caso de candidemia em paciente não neutropênico portador de AIDS, cuja origem parece ter sido via translocação através do trato gastrointestinal.

Full text available only in PDF format.

Texto completo disponível apenas em PDF.

Recebido para publicação em 13/09/1995.

Aceito para publicação em 27/06/1996.

• 1. BARCHIESI, F.; MORBIDUCCI, V.; ANCARANI, F. & SCALISE, A.D. - Trichosporon beigelii fungemia in AIDS patient. AIDS, 7: 139-140, 1993.
• 2. BRANCHINI, M.L.; PFALLER, M.A.; RHINE-CHALBERG, J.; FREMPONG, T. & ISEMBERG, H.D. - Genotipic variation and slime production among blood and catheter isolates of Candida parapsilosis. J. clin. Microbiol., 32: 452-456, 1994.
• 3. DIAMOND, R.D. - The growing problem of mycoses in patients infected with the Human Immunodeficiency Virus. Rev. infect. Dis., 13: 480-486, 1991.
• 4. DUPONT, B.; GRAYBILL, J.R.; ARMSTRONG, D. et al. - Fungal infections in AIDS patients. J. Med. vet. Mycol., 30 (suppl. 1): 19-28, 1992.
• 5. GUBBINS, P.O.; PISCITELLI, S.C. & DANZIGER, L.H. - Candidal urinary tract infections: a comprehensive review of their diagnosis and management. Pharmacotherapy, 13: 110-127, 1993.
• 6. KRAUSE, W.; MATHEIS, H. & WULF, K. - Fungemia and funguria after oral administration of C. albicans. Lancet, 1: 598-599, 1969.
• 7. LAGUNA, F. & RODRIGUEZ-TUDELA, E. - Fungemia due to fluconazole-resistant Candida albicans in a patient with AIDS. Clin. infect. Dis., 19: 542-543, 1994.
• 8. LEHRER, R.I. Inhibition by sulfonamides of the candidacidal activity of human neutrophils. J. clin. Invest., 50: 2498-2505, 1971.
• 9. WADE, J.C. Epidemiology of Candida infections. In: BODEY, G.P., ed. Candidiasis: pathogenesis, diagnosis, and treatment. 2. ed. New York, Raven Press, 1993. p. 85.
• 10. WALSH, T.J.; BUSTAMANTE, C.I.; VLAHOV, D. & STANDIFORD, H.C. - Candidal suppurative peripheral thrombophlebitis: recognition, prevention and management. Infect. Control, 7: 16-22, 1986.
• 11. WHIMBEY, E.; GOLD, J.W.; POLSKY, B. et al. Bacteremia and fungemia in patients with the acquired immunodeficiency syndrome. Ann. intern. Med., 104: 511-514, 1986.
• 12. WILKES, M.S.; FORTIN, A.H.; FELIX, J.C; GODWIN, T.A. & TOMPSON, W.G. Value of necropsy in acquired immunodeficiency syndrome. Lancet, 2: 85-88, 1988.

Correspondence to:

Arnaldo Lopes Colombo, MD

Division of Infectious Diseases/Escola Paulista de Medicina - UNIFESP

Rua Botucatu 740

04023-062 São Paulo, SP, Brazil

FAX: [phone], PHONE: [phone]

Publication Dates

• Publication in this collection
  22 Sept 2006
• Date of issue
  June 1996

History

• Accepted
  27 June 1996
• Received
  13 Sept 1995