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Revista do Instituto de Medicina Tropical de São Paulo

On-line version ISSN 1678-9946

Rev. Inst. Med. trop. S. Paulo vol.38 no.3 São Paulo May/June 1996 



Norfloxacin monodose use in patients with cholera in Salta, Argentina


El uso de monodosis de norfloxacina en pacientes con colera en Salta, Argentina



Alfredo César SeijoI; Marcos FernandezII; Carolina CamposII; Beatriz Elena CernigoiI; Mabel NoguerasI; Jorge San JuanI; Marcelo Fidel TorresII; Olindo Adrián MartinoI

IHospital de Infecciosas F. J. Muñiz - Municipalidad de la Ciudad de Buenos Aires, ARGENTINA
IIHospital de Salvador Mazza - Província de Salta, AGENTINA

Correspondence to




The use ofmonodose (800 mg) per os of Norfloxacin was evaluated in 32 patients with cholera at Salvador Mazza's Hospital, Salta, Argentina. It was considered the celerity in negativization of stool culture (100% of cases: 12 hours post administration), its efficiency along time (24/24 controlled patients were negative at 10th day) and MIC of isolated strains (100% of strains were sensitive: range 0.008 to 0.016 mg/ml). It was included oral administration of sorbitol 70% in peanut oil in order to study patients at 10th day's control. This method could be an alternative one in the study of asymptomatic carrier. Norfloxacin monodose shows good performance in early negativization of stool culture and it was also effective along the whole observation period, suggesting it could prevent carriage.

Keywords: Cholera; Treatment; Norfloxacin; Carriage.


Se evaluó el uso de monodosis (800 mg) per os de Norfloxacina en 32 pacientes con cólera en el Hospital de Salvador Mazza, Salta, Argentina. Se consideró la rapidez en la negativización del coprocultivo (100% de los casos = 12 horas post administración), su eficacia a través del tiempo (24/24 pacientes controlados fueron negativos al 10° día) y la CIM de las cepas aisladas (100% sensibles, rango 0.008 a 0.016 mg/ml). Para estudiar a los pacientes en el control del 10° día se incluyó la administración oral de sorbitol 70% en aceite de maní. Este método puede ser una alternativa en el estudio del portador asintomático. Norfloxacina en monodosis mostró buen desempeño en la pronta negativización del coprocultivo y fue también efectiva a lo largo de todo el período de observación sugiriendo que puede evitar la portación.



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Correspondence to:
Dr. Alfredo C. Seijo
Hospital F.J. Muñiz
Uspallata 2272 - (1282)
Buenos Aires, ARGENTINA

Recebido para publicação em 05/01/1996
Aceito para publicação em 05/06/1996

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