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Print version ISSN 0036-4665
Rev. Inst. Med. trop. S. Paulo vol.45 no.2 São Paulo Mar./Apr. 2003
Tuberculous brain abscess in a patient with AIDS: case report and literature review
Abscesso tuberculoso cerebral em paciente com AIDS: relato de caso e revisão da literatura
José E. Vidal; Sérgio Cimerman; Paula R. Marques da Silva; Jaques Sztajnbok; João F.G.S. Coelho; Diogo L.M. Lins
Instituto de Infectologia Emílio Ribas, São Paulo, SP, Brazil
Tuberculous brain abscesses in AIDS patients are considered rare with only eight cases reported in the literature. We describe the case of a 34-year-old woman with AIDS and previous toxoplasmic encephalitis who was admitted due to headache and seizures. A brain computed tomography scan disclosed a frontal hypodense lesion with a contrast ring enhancement. Brain abscess was suspected and she underwent a lesion puncture through a trepanation. The material extracted was purulent and the acid-fast smear was markedly positive. Timely medical and surgical approaches allowed a good outcome. Tuberculous abscesses should be considered in the differential diagnosis of focal brain lesions in AIDS patients. Surgical excision or stereotactic aspiration, and antituberculous treatment are the mainstay in the management of these uncommon lesions.
Keywords: Tuberculous abscess; Brain abscess; Acquired immunodeficiency syndrome.
Os abscessos tuberculosos cerebrais em pacientes com aids são raros, existindo apenas 8 casos publicados. Os autores relatam o caso de uma paciente de 34 anos com aids e antecedente de toxoplasmose cerebral, que foi admitida por cefaléia e convulsões. A tomografia computadorizada de crânio evidenciou lesão frontal única, grande, com realce anular e efeito expansivo. Diante da suspeita de abscesso cerebral foi submetida a trepanação, drenando material purulento e demonstrando presença de abundantes bacilos ácido-álcool resistentes. Abordagem cirúrgica e clínica oportuna determinaram uma boa evolução. Os abscessos tuberculosos devem ser considerados no diagnóstico diferencial das massas intracranianas em pacientes com aids. Excisão cirúrgica ou aspiração por estereotaxia e tuberculostáticos constituem as bases do tratamento destas lesões incomuns.
Human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS) are the major known risk factors to develop tuberculosis in individuals previously infected with Mycobacterium tuberculosis24. HIV epidemic rendered tuberculosis more prevalent and increased the indices of mortality, multidrug resistance, and extrapulmonary and disseminated forms16,27,28.
Central nervous system (CNS) is involved in 10-20% of the cases where HIV infection coexists with tuberculosis. The main clinical syndrome is tuberculous meningitis. Focal tuberculous lesions are infrequent and may appear as tuberculomas and more rarely as abscesses35.
We report a case of brain tuberculous abscess in an AIDS patient and review of the literature.
A 34-year-old woman was admitted to our service in September 2002 because of holocranial headache and generalized tonic-clonic seizures. She had a history of intravenous drug use, chronic hepatitis C, oral candidiasis, and toxoplasmic encephalitis. She had refused any prophylactic or antiretroviral therapies. Neurological examination on presentation was unremarkable, without any focal abnormalities. Laboratory revealed moderate anemia (hemoglobin of 10 g/dL), with leukopenia (white blood cell count of 1900 cells/mm3), and lymphopenia (260 cells/mm3). Chest radiograph was normal. His tuberculin skin test, using purified protein derivative (PPD) was negative. Toxoplasma IgG was higher than 250 UI (ELISA method). The absolute CD4+ count was 55 cells/µL, and HIV-RNA level was 160,000 copies/mL.
Brain computed tomography (CT) scan showed a hypodense frontal lesion with significant associated edema (Fig. 1A). She underwent trepanation on the same day, draining 10 ml of pus. The Ziehl-Neelsen stain showed abundant acid-fast bacilli (AFB). After one week, the general status improved and a new CT scan showed a decrease in the lesion size (Fig. 1B). She was discharged to home with isoniazid, rifampicin, pyrazinamide, zidovudine, lamivudine, and efavirenz. Besides that, she received primary prophylaxis for Pneumocystis carinii pneumonia and secondary prophylaxis for toxoplasmic encephalitis.
Tuberculous brain abscesses are infrequently described in the world literature. Before the AIDS era, WHITENER33 reviewed from 1886 to 1978 only 17 cases with etiological diagnosis, and established diagnosis criteria of cerebral tuberculous abscess. In these patients were not reported any information about preexisting conditions or non-infectious diseases.
In the AIDS era, we reviewed the literature from 1981 to 2002 using the MEDLINE database (National Library of Medicine, Bethesda, MD). The key words used were tuberculous brain abscess, cerebral abscess and acquired immunodeficiency syndrome. We also searched manually in journals, and cases with incomplete clinical or microbiologic information were excluded. In accordance with WHITENER's criteria33, we found 8 cases of tuberculous brain abscesses in HIV-infected patients: three in the USA12,13,14, three in Spain29,31, one in France11 and one in Brazil17. One of these cases was associated with toxoplasmic encephalitis13. Interestingly, we excluded three cases previously reported as tuberculous abscesses31. However, histopathology information corresponded to tuberculomas6.
The histopathologic features of tuberculous abscess are different from those of tuberculomas and the definitive diagnosis depends on the following criteria: macroscopic evidence of pus in the abscess cavity, microscopic evidence of acute inflammatory alterations in the abscess walls, and the presence of AFB or M. tuberculosis growth on culture30,33. Tuberculous abscesses are generally single lesions11,12,13,17,29,31, larger than tuberculomas2 and also evolve more rapidly32. The exact pathogenesis mechanisms leading to formation of abscess are unknown. It is hypothesized that after the initial hematogenic dissemination of the bacilli34, there would be brain areas of cerebritis that go on to meningitis or tuberculomas. The abscesses would come from caseous necrosis and liquefaction of these tuberculomas10 .
In AIDS era, tuberculous brain abscess usually is a subacute illness and the most frequent clinical manifestations are seizures12,17,31, consciousness alterations11,29,31, paresis12,14,17, fever11,13,17, and headache11,17,31. Other findings are paresthesias12,17, cerebelar signs11,31, facial palsy31, and intracranial hypertension11. Before AIDS era, WHITENER33 reported that patients with tuberculous brain abscess usually had an acute illness, and the most common finding were focal neurological deficit (71%), headache (47%), fever (46%), seizures (35%) and consciousness alterations (24%).
Our case is in accordance with other reports of AIDS patients, specially in what concerns the lack of a previous occurrence of tuberculosis11,12,13,17,31, history of use of intravenous drugs12,29,31, and normal chest radiographs11-13,17,29,31. Formerly, WHITENER33 reported that patients with tuberculous brain abscess frequently presented epidemiological, historical or laboratory evidence of extracranial tuberculosis, but chest radiographs consistent with tuberculosis were uncommon.
Only four of eight cases found in the literature performed serology for T. gondii11-13,17. All these patients had detectable IgG antibodies. It is known that 3-6% of patients with toxoplasmic encephalitis have negatives results of serological tests26, so that a negative serology points to another etiologic possibilities. The positive serology in our case was justified by the previous episode of CNS toxoplasmosis.
The major causes of intracranial focal lesions coexist with low CD4+ values, typically below 100 cells/µL26. CD4+ values for tuberculous abscesses without other CNS infections are reported to be between 112-270 cells/µL12,31. This important finding for the diagnostic reasoning would be misleading in our case since her CD4+ cell count was 55 cells/µL. This finding and the history of toxoplasmic encephalitis and the lack of secondary prophylaxis for this opportunistic infection could have retarded the diagnostic trepanation, and consequently delayed the treatment.
Tomographic alterations of the tuberculous abscesses may be similar to those ones related to other causes of expansive lesions in AIDS patients32: a hyperdense ring, hypodense center, and marked contrast enhancement. The presence of single lesions, a thick capsule, ring enhancement, and a lobular contour, make the diagnosis of tuberculous abscess more likely12,17,22,25,31,32. On the other hand, toxoplasmic encephalitis lesions in general are multiple, their capsules are not thick and are not multilobulated.
The differential diagnosis of tuberculous abscesses is wide, including toxoplasmic encephalitis (the most frequent cause of intracranial mass in AIDS patients) and CNS primary lymphoma19,21,23,26. Moreover, other rare causes have been described such as tuberculoma18, cryptococcal abscess and cryptococcoma21, non-tuberculous mycobacteria abscess15, pyogenic abscess12, syphilitic gumma23, aspergilloma20, Chagas disease9, and intracranial mass due to cytomegalovirus5.
The AIDS patients with focal brain lesions, presence of IgG antibodies against T. gondii and CD4+ cell count below 200 cells/µL should receive anti-Toxoplasma treatment. If after two weeks of treatment there are no clinical or tomographic improvement, a stereotaxic brain biopsy is needed22. However, as reported in a case of "cytomegaloviroma"5, a high index of suspicion may justify earlier surgical approaches. In accordance with this suggestion, our patient underwent a trepanation on the first hospital day.
The availability of imaging techniques such as Thallium-201 single-photon emission CT (SPECT)19, positron emission tomography (PET)26, spectroscopic magnetic resonance imaging7 and molecular techniques (polymerase chain reaction in cerebrospinal fluid)3,26 may add to the diagnostic strategy. These tools allow "minimally invasive" approach, decrease the number of brain biopsies, and increase the number of in vivo diagnosis3,4,8,19,26. However, until larger validation studies are completed, brain biopsy will continue the only definitive diagnosis modality26.
Biopsy and early treatment of tuberculous brain abscess in AIDS patients, allowed a good outcome in the majority of the reported cases11,12,14,17,31. No one of these patients had another associated CNS disease, and all deaths observed were linked to other causes than the abscesses themselves13,29,31. Interestingly, before AIDS era, WHITENER33 reported survival in all cases that received antituberculous chemotherapy and underwent surgical treatment.
Considering the present case, tuberculous brain abscess, in spite of its rarity, must be included in the differential diagnosis of focal lesions in AIDS patients. A high index of suspicion may define an earlier surgical excision or stereotaxic biopsy, which are considered to be the gold standard for the diagnosis and treatment of tuberculous brain abscess.
The authors thank Adrián V. Hernández, MD, MSc., for his comments and assistance in preparation of the manuscript.
1. ABOS, J.; GRAUS, F.; MIRO, J.M. et al. - Intracranial tuberculomas in patients with AIDS. AIDS, 5: 461-462, 1991. [ Links ]
2. ADAMS, J.H.; CORSELLIS, J.A.N. & DUCHEN, L.W. - Greenfield's Neuropathology. New York, Wiley, 1984. p. 251. [ Links ]
3. ANTINORI, A.; AMMASSARI, A.; DE LUCA, A. et al. - Diagnosis of AIDS-related focal brain lesions: a decision-making analysis based on clinical and neuroradiologic characteristics combined with polymerase chain reaction assays in CSF. Neurology, 48: 687-694, 1997. [ Links ]
4. ANTINORI, A.; AMMASSARI, A.; LUZZATI, R. et al. - Role of brain biopsy in the management of focal brain lesions in HIV-infected patients. Gruppo Italiano Corporativo AIDS & Tumori. Neurology, 54: 993-997, 2000. [ Links ]
5. BASSIL, H.F. & WILLIAM, D.C. - Cytomegalovirus encephalitis in an HIV positive patient presenting with a cerebral mass lesion. AIDS Patient Care and STDs, 11: 319-321, 1997. [ Links ]
6. BISHBURG, E.; SUNDERAM, G.; REICHMAN, L.B. & KAPILA, R. - Central nervous system tuberculosis with the acquired immunodeficiency syndrome and its related complex. Ann. intern. Med., 105: 210-213, 1986. [ Links ]
7. CHANG, L.; MILLER, B.L.; McBRIDE, D. et al. - Brain lesions in patients with AIDS: H-1 MR spectroscopy. Radiology, 197: 525-531, 1995. [ Links ]
8. CINGOLANI, A.; DE LUCA, A.; LAROCCA, L.M. et al. - Minimally invasive diagnosis of acquired immunodeficiency syndrome-related primary central nervous system lymphoma. J. nat. Cancer Inst., 90: 364-369, 1998. [ Links ]
9. CORTI, M. - AIDS and Chagas disease. AIDS Patient Care and STDs, 14: 581-588, 2000. [ Links ]
10. DASTUR, H.M. - A tuberculoma review with some personal experiences. I. Brain. Neurol. India, 20: 111-126, 1972. [ Links ]
11. DECHAMBENOIT, G.; BONI, N.G.; SANTINI, J.J. et al. - Abcès tuberculeux du cervelet. Neurochirurgie, 39: 326-329, 1993. [ Links ]
12. FARRAR, D.J.; FLANIGAN, T.P.; GORDON, N.M.; GOLD, R.L. & RICH, J.D. - Tuberculous brain abscess in a patient with HIV infection: case report and review. Amer. J. Med., 102: 297-301, 1997. [ Links ]
13. FISCHL, M.A.; PITCHENICK, A.E. & SPIRA, T.J. - Tuberculous brain abscess and Toxoplasma encephalitis in a patient with the acquired immunodeficiency syndrome. J. Amer. med. Ass., 253: 3428-3430, 1985. [ Links ]
14. GETTLER, J.F. & GARNER, B.F. - Long-term survival of an AIDS patient with a tuberculous cerebral abscess. J. nat. med. Ass. (N.Y.), 88: 605-606, 1996. [ Links ]
15. GORDON, S.M. & BLUMBERG, H.M. - Mycobacterium kansasii brain abscess in a patient with AIDS. Clin. infect. Dis., 14: 789-790, 1992. [ Links ]
16. ISELMAN, M.D. - Treatment of multidrug-resistant tuberculosis. New Engl. J. Med., 329: 784-791, 1993. [ Links ]
17. MACHADO, D.M.; MARCHIORI, E.; PRAXEDES, M.C.; MALHEIROS, N.R. & SANTOS, A.A. - Abscesso cerebral tuberculoso na SIDA: relato de um caso. Radiol. bras., 28: 343-346, 1995. [ Links ]
18. MALASKY, C. & REICHMAN, L.B. - Long-term follow-up of tuberculoma of the brain in an AIDS patient. Chest, 101: 278-279, 1992. [ Links ]
19. MAMIDI, A.; DeSIMONE, J.A. & POMERANTZ, R.J. - Central nervous system infections in individuals with HIV-1 infection. J. Neurovirol., 8: 158-167, 2002. [ Links ]
20. MYLONAKIS, E.; PALIOU, M.; SAX, P.E. et al. - Central nervous system aspergillosis in patients with human immunodeficiency virus infection. Medicine (Baltimore), 79: 269-280, 2000. [ Links ]
21. PRICE, R.W. & WORLEY, J.M. - Management of neurologic complications of HIV-1 infection and AIDS. In: SANDE, M.A. & VOLPERING, P.A., ed. The medical management of AIDS. Philadelphia, W.B. Saunders, 1995. p. 261-288. [ Links ]
22. REICHENTAL, E.; COHEN, M.L.; SCHUJMAN, C.B.; EYNAN, N. & SHALIT, M. - Tuberculous brain abscess and its appearance on computadorized tomography. J. Neurosurg., 56: 597-600, 1982. [ Links ]
23. REPORT OF THE QUALITY STANDARDS SUBCOMMITTEE OF THE AMERICAN ACADEMY OF NEUROLOGY - Evaluation and management of intracranial mass lesions in AIDS. Neurology, 50: 21-26, 1998. [ Links ]
24. SEPKOWITZ, K.A.; RAFFALLI, J.; RILEY, L.; KIEHN, T.E. & ARMSTRONG, D. - Tuberculosis in the AIDS era. Clin. Microbiol. Rev., 8: 180-199, 1995. [ Links ]
25. SHELLER, J.R. & DES PREZ, R.M. - CNS tuberculosis. Neurol. Clin., 4: 143-158, 1986. [ Links ]
26. SKIEST, D.J. - Focal neurological disease in patients with acquired immunodeficiency syndrome. Clin. infect. Dis., 34: 103-115, 2002. [ Links ]
27. SLUTSKER, L.; CASTRO, K.G.; WARD, J.W. & DOOLEY Jr., S.W. - Epidemiology of extrapulmonary tuberculosis among persons with AIDS in the United Stated. Clin. infect. Dis., 16: 513-518, 1993. [ Links ]
28. SMALL, P.M.; SCHECTER, G.F.; GOODMAN, P.C. et al. - Treatment of tuberculosis in patients with advanced human immunodeficiency virus infection. New Engl. J. Med., 324: 289-294, 1991. [ Links ]
29. TRILLA, A.; GRAUS, F.; ANANOS, G. & NAVARRO, M. - Abceso cerebral tuberculoso y síndrome da inmunodeficiencia adquirida. Med. clin. (Barcelona), 93: 236, 1989. [ Links ]
30. TYSON, G.; NEWMAN, P. & STRACHAN, W.E. - Tuberculous brain abscess. Surg. Neurol., 10: 323-325, 1978. [ Links ]
31. VELASCO MARTINEZ, J.J.; GUERRERO ESPEJO, A.; GOMEZ MAMPASO, E.; NAVAS ELORZA, E. & GARCIA RIBAS, G. - Tuberculous brain abscess should be considered in HIV/AIDS patients. AIDS, 9: 1197-1199, 1995. [ Links ]
32. WHITEMAN, M.; ESPINOZA, L.; POST, J.D.; BELL, M.D. & FALONE, S. - Central nervous system tuberculosis in HIV-infected patient: clinical and radiographic findings. AJNR Amer. J. Neuroradiol., 16: 1319-1327, 1995. [ Links ]
33. WHITENER, D.R. - Tuberculous brain abscess. Report of a case and review of the literature. Arch. Neurol., 35: 148-155, 1978. [ Links ]
34. YANG, P.J.; REGER, K.M.; SEEGER, J.F.; CARMODY, R.F. & IACONO, R.P. - Brain abscess: an atypical CT appearance of CNS tuberculosis. AJNR Amer. J. Neuroradiol., 8: 919-920, 1987. [ Links ]
35. ZUGER, A. & LOWY, F.D. - Tuberculosis. In: SCHELD, W.M.; WHITLEY, R.J. & DURACK, D.T., ed. Infections of the central nervous system. 2.ed. Philadelphia, Lippincott-Raven, 1997. p. 417-443. [ Links ]
Dr. José E. Vidal
Rua Capote Valente 668, Apto. 96
05409-002 São Paulo, SP, Brazil
Telephone number: (55.11) 95888756; (55.11) 30853319. Fax number: (55.11) 30883602
Received: 02 December 2002
Accepted: 03 February 2003