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Revista do Instituto de Medicina Tropical de São Paulo

On-line version ISSN 1678-9946

Rev. Inst. Med. trop. S. Paulo vol.49 no.4 São Paulo Jul./Aug. 2007

http://dx.doi.org/10.1590/S0036-46652007000400015 

CASE REPORT

 

Soft tissue abscess and lymphadenitis due to Mycobacterium avium Complex as an expression of immune reconstitution inflammatory syndrome after a second scheme of highly active antiretroviral therapy

 

Linfadenitis y absceso subcutáneo por Complejo Mycobacterium avium como manifestación de síndrome inflamatorio de reconstitución inmune luego de un segundo esquema de terapia antirretroviral de gran actividad

 

 

Marcelo CortiI; María F. VillafañeI; Marta AmbroggiII; Mirna SawickiIII; Elisa GancedoIII

IDivision of HIV/AIDS, Infectious Diseases F. J. Muñiz Hospital, Buenos Aires, Argentina
IIMycobacterial Laboratory, Infectious Diseases F. J. Muñiz Hospital, Buenos Aires, Argentina
IIIUltrasonography Section, Infectious Diseases F. J. Muñiz Hospital, Buenos Aires, Argentina

Correspondence to

 

 


SUMMARY

Immune reconstitution inflammatory syndrome (IRIS) is an atypical and unexpected reaction related to highly active antiretroviral therapy (HAART) in human immunodeficiency virus (HIV) infected patients. IRIS includes an atypical response to an opportunistic pathogen (generally Mycobacterium tuberculosis, Mycobacterium avium complex, cytomegalovirus and herpes varicella-zoster), in patients responding to HAART with a reduction of plasma viral load and evidence of immune restoration based on increase of CD4+ T-cell count. We reported a case of a patient with AIDS which, after a first failure of HAART, developed a subcutaneous abscess and supraclavicular lymphadenitis as an expression of IRIS due to Mycobacterium avium complex after starting a second scheme of HAART.

Keywords: HAART; Immune reconstitution inflammatory syndrome; Mycobacterium avium complex.


RESUMEN

El síndrome inflamatorio de reconstitución inmune (SIRI) es una reacción atípica e inesperada relacionada con el tratamiento antirretroviral de gran actividad (TARGA) en pacientes infectados por el virus de la inmunodeficiencia humana (VIH). El SIRI representa una respuesta inflamatoria frente a un patógeno oportunista (generalmente Mycobacterium tuberculosis, Complejo Mycobacterium avium, citomegalovirus y herpes varicela-zóster) en pacientes que responden a la TARGA con una marcada reducción de la carga viral en plasma y evidencia de una recuperación inmunológica expresada por el incremento de los niveles de linfocitos T CD4+. Presentamos el caso de un paciente con síndrome de inmunodeficiencia adquirida que desarrolló un absceso subcutáneo en muslo derecho y una adenitis supraclavicular izquierda como manifestación de SIRI por Complejo Mycobacterium avium luego del inicio de un segundo esquema de TARGA.


 

 

INTRODUCTION

The immune reconstitution inflammatory syndrome (IRIS) includes several responses to preexisting opportunistic infections or tumors after the restoration of immune function in human immunodeficiency virus (HIV) infected patients receiving highly active antiretroviral therapy (HAART)10,12. Before the HIV pandemic, IRIS was also described in patients with chronic diseases such as leprosy and tuberculosis2,7,16. Since the extending use of HAART, numerous papers describing episodes of IRIS have been published in the medical literature5,17, and IRIS became frequent (29% to 36%) in patients with history of tuberculosis in the HAART era11.

We describe a patient, which developed a soft tissue abscess and a focal supraclavicular lymphadenitis due to Mycobacterium avium complex (MAC) after starting a second scheme of HAART.

 

CASE REPORT

A 32-year-old man, seropositive for human immunodeficiency virus (HIV), with history of disseminated histoplasmosis and Mycobacterium avium complex disseminated disease, was started on highly active antiretroviral therapy (HAART) based on zidovudine plus lamivudine plus nevirapine. At this moment, his plasma viral load was > 500,000 copies/mL (5.7 log10 copies/mL) and his CD4+ T-cell count was < of 50 cell/µL. He presented an initial good clinical, virological and immunological response to this scheme of HAART. Three months later, his plasma viral load was 32,814 copies/mL (4.52 log10 copies/mL) and the CD4+ T-cell count was 361 cell/µL (21%). Six months later he evidenced a virological failure with a rebound of the plasma viral load (76,222 copies/mL/4.89 log10 copies/mL) and with a loss of CD4+ T-cell count (289 cell/µL 20%).

At this moment, HAART was modified; then, he received a new scheme based on abacavir plus didanosine plus saquinavir boosted with ritonavir.

Two months later, with a plasma viral load of 424 copies/mL (2.63 log10 copies/mL) and CD4+ T-cell count of 348 cell/µL (18%), he presented with fever, supraclavicular lymphadenitis (Fig. 1A) and pain with tender and inflammatory swelling located at the right thigh. Ultrasonography revealed the existence of a hypoechoic soft tissue liquid collection of 79 x 31 x 26 mm of diameters consistent with an abscess (Fig. 2). Aspiration of this mass and the supraclavicular lymphadenopathy showed pus that contained scanty acid-fast bacilli. Culture of this material was negative.

 

 

 

 

 

 

We supported the same scheme of HAART and antimycobacterial treatment with ciprofloxacin, ethambutol and clarithromycin plus non-steroid anti-inflammatory was started. Four months later, the patient was in a good clinical condition and the symptoms of lymphadenitis and the soft tissue abscess resolved (Fig. 1B). At this time, the plasma viral load was 168 copies/mL (2.23 log10) and the CD4+ T-cell count was 447 cell/µL (16%).

 

DISCUSSION

IRIS has been reported for a limited number of patients with various and previous opportunistic infections and tumors associated with AIDS immunodeficiency despite the adequate control of virologic and immunologic parameters5,11,17. IRIS is an inflammatory reaction which appears after initiating or changing of HAART regimens and is temporally related with an increase in the CD4+ T-cell counts3,8.

The real incidence of IRIS during HAART is unknown; however, SHELBURNE et al.18 in a cohort of 180 HIV-infected subjects who received HAART observed that 31.7% of these patients developed IRIS. KUMARASAMY et al.9 published an incidence of 15.2 cases/100 patients/year to IRIS related with tuberculosis. NARITA et al.14 published a prevalence of 36% for Mycobacterium tuberculosis-associated IRIS.

IRIS appears to reflect an immune response against an active infection by opportunistic pathogens and is associated with delayed-type hypersensitivity responses to mycobacterial antigens6.

The most frequent manifestations of IRIS published in the medical literature were MAC lymphadenitis, cytomegalovirus uveitis and cutaneous herpes zoster18. Major criteria to defining IRIS include the develop of an opportunistic infection or tumor, including an atypical presentation, in patients responding to HAART with a reduction of plasma HIV-RNA level more than one log10 copies/mL, without other explanation and with evidence of immune restoration, as minor criteria6.

The temporal association between IRIS and the initiation of HAART has not been well established. PHILLIPS et al.15 reported two patients with musculoskeletal disease for whom the intervals between HAART and IRIS were one and two years, respectively. The late onset of IRIS due to MAC has been described in patients with bone involvement1. The majority of IRIS cases associated with MAC infections evolve within the three months after starting HAART. In a large series of 51 patients with IRIS related to nontuberculous mycobacterias, the median interval from initiation of HAART to the onset of IRIS symptoms was three weeks (range one to eight weeks), but the median interval since the onset of symptoms to the diagnostic procedure was 10 weeks (range six to 19 weeks)15.

Generally, patients with diagnosis of IRIS associated with MAC presented with inespecific symptoms as fever, fatigue and lymphadenitis with involvement of major lymph nodes regions: the cervical and supraclavicular regions, the thoracic including the mediastinum and the abdominal cavity. However, besides the lymphadenitis of different regions, IRIS associated with MAC and other nontuberculous mycobacterias include a variety of clinical presentations such as soft tissue abscesses, monoarthritis, lung cavity, endobronquial lesions, thoracic and spine mass lesion and MAC bacteremia15. In the PHILLIPS' serie15, 17 of 51 patients (33%) presented with peripheral lymphadenopathy; 15 (29%) with pulmonary and thoracic disease and 13 (25%) with abdominal compromise.

Primary or secondary MAC prophylaxis did not protect against the development of IRIS. PHILLIPS et al.15 published a large series of nontuberculous mycobacterial IRIS including 51 patients (43 with MAC infection). Thirty eight (75%) of these patients had no history of mycobacterial disease.

In this serie15, the median of CD4+ T-cell counts at baseline (pre-HAART) was 20 cell/µL (range 10 to 50) and the median at IRIS diagnosis was 120 cell/µL (range 70 to 180). In the same series, the median of viral load at baseline was 230,000 copies/mL and at the time of IRIS diagnosis was < 500 copies/mL.

IRIS is an inflammatory syndrome that may cause atypical and clinical manifestations with a variety of outcomes ranging from minimal disease to occasionally fatal progression. For example, in a case published by VENDRELY et al.19 about a patient who presented a progressive multifocal leucoencephalopathy as a manifestation of IRIS or in other patients with cryptococosis-associated IRIS13.

Treatment for this complication of AIDS therapy includes the continuation of primary therapy against the pathogen implicated in the IRIS to decrease the antigenic load, the continuation of HAART and, eventually, the use of non-steroid antiinflammatory agents and corticosteroids8,17. IRIS is a condition thought to be caused by the improvement in the host's immune response to several pathogens. IRIS is common among HIV-infected patients and co-infected with MAC, Mycobacterium tuberculosis or other pathogens. Diagnosis of IRIS is difficult for clinicians; differential diagnosis includes treatment failure or resistance and other opportunistic diseases4,13.

This disorder should be suspected in patients who start HAART in close proximity to the diagnosis of an opportunistic infection and have a rapid decline in the HIV viral load and an immune restoration associated with a rapid increase in the CD4+ T-cell counts.

 

REFERENCES

1. ABERG, J.A.; CHIN-HONG, P.V.; Mc CUTCHAN, A.; KOLETAR, S.L. & CURRIER, J.S. - Localized osteomyelitis due to Mycobacterium avium complex in patients with human immunodeficiency virus receiving highly active antiretroviral therapy. Clin. infect. Dis., 35: 8-13, 2002.         [ Links ]

2. CHENG, V.C.C.; YUEN, K.Y.; CHAN, W.M. et al. - Immunorestitution disease involving the innate and adaptive response. Clin. infect. Dis., 30: 882-892, 2000.         [ Links ]

3. CONNICK, E.; KANE, M.A.; WHITE, I.E.; RYDER, J. & CAMPBELL, T.B. -Immune reconstitution inflammatory syndrome associated with Kaposi sarcoma during potent antiretroviral therapy. Clin. infect. Dis., 39: 1852-1855, 2004.         [ Links ]

4. DEAN, G.L.; EDWARDS, S.G.; IVES, N.J. et al. - Treatment of tuberculosis in HIV-infected persons in the era of highly active antiretroviral therapy. AIDS, 16: 75-83, 2002.         [ Links ]

5. De SIMONE, J.A.; POMERANTZ, R.J. & BABINCHACK, T.J. - Inflammatory reactions in HIV-1-infected persons after initiation of active antiretroviral therapy. Ann. intern. Med., 133: 447-454, 2000.         [ Links ]

6. FRENCH, M.A.; PRICE, P. & STONE, S.F. - Immune restoration disease after antiretroviral therapy. AIDS, 18: 1615-1627, 2004.         [ Links ]

7. GOEBEL, F.D. - Immune reconstitution inflammatory syndrome (IRIS) - another new disease entity following treatment initiation of HIV infection. Infection, 33: 43-45, 2005.         [ Links ]

8. HIRSCH, H.H.; KAUFMANN, G.; SENDI, P. & BATTEGAY, M. - Immune reconstitution in HIV-infected patients. Clin. infect. Dis.; 38: 1159-1166, 2004.         [ Links ]

9. KUMARASAMY, N.; CHAGUTURU, S.; MAYER, K.H. et al. - Incidence of immune reconstitution syndrome in HIV/tuberculosis co-infected patients after initiation of generic antiretroviral therapy in India. J. acquir. immune Defic. Syndr., 37: 1574-1576, 2004.         [ Links ]

10. LAWN, S.D.; BICANIC, T.A. & MACALLAN, D.C. - Pyomyositis and cutaneous abscesses due to Mycobacterium avium: an immune reconstitution manifestation in a patient with AIDS. Clin. infect. Dis., 38: 461-463, 2004.         [ Links ]

11. LAWN, S.D.; BEKKER, L.G. & MILLER, R.F. - Immune reconstitution disease associated with mycobacterial infections in HIV-infected individuals receiving antiretrovirals. Lancet infect. Dis., 5: 361-373, 2005.         [ Links ]

12. LAWN, S.D.; CHECKLEY, A. & WANSBROUGH-JONES, M.H. - Acute bilateral parotiditis caused by Mycobacterium scrofulaceum: immune reconstitution disease in a patient with AIDS. Sex. transm. infect., 81: 517-518, 2005.         [ Links ]

13. LORTHOLARY, O.; FONTANET, A.; MÉMAIN, N. et al. - Incidence and risk factors of immune reconstitution inflammatory syndrome complicating HIV-associated cryptococcosis in France. AIDS, 19: 1043-1049, 2005.         [ Links ]

14. NARITA, M.; ASHKIN, D.; HOLLENDER, E.S. & PITCHENIK, A.E. - Paradoxical worsening of tuberculosis following antiretroviral therapy in patients with AIDS. Amer. J. resp. crit. Care Med., 158: 157-161, 1998.         [ Links ]

15. PHILLIPS, P.; BONNER, S.; GATARIC, N. et al. - Nontuberculous mycobacterial immune reconstitution syndrome in HIV-infected patients: spectrum of disease and long-term follow-up. Clin. infect. Dis., 41: 1483-1497, 2005.         [ Links ]

16. SHARMA, P.; KAR, H.K.; MISRA, R.S. et al. - Reactional states and neuritis in multibacillary leprosy patients following multidrug therapy with/without immunotherapy with Mycobacterium w antileprosy vaccine. Lepr. Rev., 71: 193-205, 2000.         [ Links ]

17. SHELBURNE, S.A III.; HAMILL, R.J.; RODRIGUEZ-BARRADAS, M.C. et al. - Immune reconstitution inflammatory syndrome. Emergence of a unique syndrome during highly active antiretroviral therapy. Medicine (Baltimore), 81: 213-227, 2002.         [ Links ]

18. SHELBURNE, S.A.; VISNEGARWALA, F.; DARCOURT, J. et al. - Incidence and risk factors for immune reconstitution inflammatory syndrome during highly active antiretroviral therapy. AIDS, 19: 399-406, 2005.         [ Links ]

19. VENDRELY, A.; BIENVENU, B.; GASNAULT, J. et al. - Fulminant inflammatory leukoencephalopathy associated with HAART-induced immune restoration in AIDS-related progressive multifocal leukoencephalopathy. Acta neuropath. (Berl.), 109: 449-455, 2005.         [ Links ]

 

 

Correspondence to:
Marcelo Corti
Division of HIV/AIDS
Infectious Diseases F. J. Muñiz Hospital
Puán 381 2º Postal code C 1406 CQG
Buenos Aires, Argentina
E-mail: marcelocorti@fibertel.com.ar

Received: 28 June 2006
Accepted: 24 January 2007

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