The avirulence of the cultivated PF strain of Trypanosoma cruzi: VI - The effect of antilymphocytic serum in dogs

Menezes, Humberto

doi:10.1590/S0037-86821974000500001

Abstracts

The use of antilymphocytic serum (ALS) in dogs suppressed the immune response of a vacclnated and simultaneously ALS treated animal, increased the infectivity of a virulent strain and did not induce a typical infectian-disease in 3 dogs receiving the serum and the avirulent PF strain.

Soro antilinfocitário ALS anti-cão mostrou-se capaz de agravar uma infecção produzida pela cepa virulenta Y do Trypanosoma cruzi (Graph I, Table 4). Cães vacinados com a cepa avirulenta PF não demonstraram, 9 meses após o início da experiência, qualquer sinal de infecção-doença, apesar das altas doses de soro recebidas (Graph I, Tables 1-3). O soro é um poderoso imunosupressor capaz de impedir o desenvolvimento de defesas imunitárias em um animal injetado com a cepa PF e simultaneamente tratado com o mesmo (Table 6).

The avirulence of the cultivated PF strain of Trypanosoma cruzi. VI - The effect of antilymphocytic serum in dogs

Humberto Menezes

Departamento de Genética e Matemática Aplicada à Biologia. Fac. Med. Rib. Preto, USP. 14.100, Ribeirão Preto. SP, Brasil

SUMMARY

The use of antilymphocytic serum (ALS) in dogs suppressed the immune response of a vacclnated and simultaneously ALS treated animal, increased the infectivity of a virulent strain and did not induce a typical infectian-disease in 3 dogs receiving the serum and the avirulent PF strain.

RESUMO

Soro antilinfocitário ALS anti-cão mostrou-se capaz de agravar uma infecção produzida pela cepa virulenta Y do Trypanosoma cruzi (Graph I, Table 4).

Cães vacinados com a cepa avirulenta PF não demonstraram, 9 meses após o início da experiência, qualquer sinal de infecção-doença, apesar das altas doses de soro recebidas (Graph I, Tables 1-3).

O soro é um poderoso imunosupressor capaz de impedir o desenvolvimento de defesas imunitárias em um animal injetado com a cepa PF e simultaneamente tratado com o mesmo (Table 6).

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1. ABAZA, H. M. ; NOLAN, B. ; WATT, J. G. & WOODRUFF, M. F. A. - Effect of antilymphocytic serum in the survival of renal transplantin dogs. Transplantion 4: 618-632, 1960.
2. ARGYRIS, B. F. & PLOTKIN, D. H. - Effects of antimacrophage, antithymocyte and antispleen serum on the immune response in mice. Clin Exp. immunol. 7: 551-546, 1970.
3. BRENER, Z. & CHIARI, E. - The effects of seme immunosuppressive agents in experimental chronic Chagas's disease. Trans. Roy. Soc. Trop. Med. & Hyg. 65: 629-636, 1971.
4. BRENER, Z. - Contribuição ao estudo da terapêutica experimental da Doença de Chagas Tese. Belo Horizonte. Fac. Farm. Odont. Univ. Minas Gerais, 1951.
5. BRYCESON, A. D. M. & TURK, J. L. - The effect of prolonged treatment with antilymphocyte serum on the course of infections with BCG and Leishmania enriettii in guinea pig. J. Pa th. 104: 153-165, 1971.
6. CAMARGO, M. E. ; KLOETZEL, J. & BACHELLA, T. - A note on the haverting of large numbers of Trypanosoma cruzi blood forms in adult dogs. Rev. Inst. Med. Trop. S. Paulo, 12: 217-220, 1970.
7. DENMAN, A. M. ; DENMAN, E. J. & EMBLTNG, P. H. - Changes in the life span of circulating small lymphocytes in mice after treatment with anti-lymphocyte globulin Lancet. 1: 321-325, 1968.
8. IWASAKI, Y. ; PORTER, K. A. ; AMEND, J. R. ; MARCHIORO, T L. ; ZULK, V. & STARZIN, T. E. - The preparation and testing of horse antidog and anti-human antilymphoid plasma or serum and its protein fractions. Surg. Gynec. & Obst. 124:1-24, 1967.
9. KUMAR, R. ; KLINE, I. K. & ABELMANN, W. H. - Immunosupprefion in experimental acute and sub-acute chagasic myocarditis. Am. J. Trop. Med. & Hyg. 19: 932-939, 1970.
10. LEVEY, R. H. & MEDAWAR, P. B. - Some experlments on the action of antilymphoid antisera. Ann. N. York Acad. Sei. 129: 164-177, 1966.
11. LUCKINS, A. G. - The effects of antilymphocyte serum and cycloohosphamide on the course of infection of T. brucei and T. congolense in rats and mice. Trans. Roy. Soc Trop. Med. & Hyg. 63: 423-42.4, 1969.
12. MEDAWAR, P. B. - Immunosuppressive agents with special reference to antilymphocytic serum. Proc. Roy. Soc. London. B. 174: 155-172, 1969
13. MENEZES, H. - Active immunization of dogs with a non virulent strain of Trypanosoma cruzi. Rev. Inst. Med. Trop. S. Paulo, 11: 258-263, 1969.
14. I - The avirulent of the cultivated Y strain of Trypanosoma cruzi. Rev. Inst. Med. Trop. S. Paulo, 12: 64-68, 1970.
15. II - The avirulence of the cultivated Y strain of Trypanosoma cruzi. Rev. Inst. Med. Trop. S. Paulo, 12: 129-135, 1970.
16. III - The avirulence of the cultivated Y strain of Trypanosoma cruzi. Rev. Inst. Med. Trop. S. Paulo, 13: 14-17, 1971.
17. The avirulence of the cultivated Y strain of Trypanosoma cruzi. IV - The effect of immunosuppressive agents in mice. Rev. Soc. Bras. Med. Trop. 6: 80-84, 1972.
18. MITCHISON, N. A. - Mechanism of action of antilymphocyte serum. Fed. Proceed. 29: 222-223. 1970.
19. STROTJT, R. G. - Method for concentrating hemoflagellates J. Parasit. 48: 100, 1962.
20. THIERMAN, J. E. & CHRISTEN, R. A. - Influencia del acetato de cortisona y de la aureomicina como agente agravador de la infection chagasica atenuada. Bol. inform. parasit. Chil 7: 5355, 1952.
21. VILCHES, A. M. ; KATZIN, A. ; GOLFERA, H. & SCHMUNIS, G. A. - The effect of heterologous anti-thymocyte serum upon the course of infection with Trypanosoma cruzi in mice, Tropenmed. Parasit. 24: 279-284, 1973.
22. WALKER P. J. - The virulence of infections of P. bergei and T. rhodesiense in animais Whose immune response has been impaired by radiation or antilymphocyte serum. J. Protozool. 15: 33, 1968. Supl.
23. WOODRUFF, M. F. A. & ANDERSON, N. F. - The effect of lymphocyte depletion by thoracic duct fistula and administration of anti-lymphocytic serum on survival of homographs in rats. Ann. N. York Acad. Sei. 120: 119-128, 1965.

Publication Dates

Publication in this collection
19 June 2013
Date of issue
Oct 1974

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. ABAZA, H. M. ; NOLAN, B. ; WATT, J. G. & WOODRUFF, M. F. A. - Effect of antilymphocytic serum in the survival of renal transplantin dogs. Transplantion 4: 618-632, 1960.

[2] 2. ARGYRIS, B. F. & PLOTKIN, D. H. - Effects of antimacrophage, antithymocyte and antispleen serum on the immune response in mice. Clin Exp. immunol. 7: 551-546, 1970.

[3] 3. BRENER, Z. & CHIARI, E. - The effects of seme immunosuppressive agents in experimental chronic Chagas's disease. Trans. Roy. Soc. Trop. Med. & Hyg. 65: 629-636, 1971.

[4] 4. BRENER, Z. - Contribuição ao estudo da terapêutica experimental da Doença de Chagas Tese. Belo Horizonte. Fac. Farm. Odont. Univ. Minas Gerais, 1951.

[5] 5. BRYCESON, A. D. M. & TURK, J. L. - The effect of prolonged treatment with antilymphocyte serum on the course of infections with BCG and Leishmania enriettii in guinea pig. J. Pa th. 104: 153-165, 1971.

[6] 6. CAMARGO, M. E. ; KLOETZEL, J. & BACHELLA, T. - A note on the haverting of large numbers of Trypanosoma cruzi blood forms in adult dogs. Rev. Inst. Med. Trop. S. Paulo, 12: 217-220, 1970.

[7] 7. DENMAN, A. M. ; DENMAN, E. J. & EMBLTNG, P. H. - Changes in the life span of circulating small lymphocytes in mice after treatment with anti-lymphocyte globulin Lancet. 1: 321-325, 1968.

[8] 8. IWASAKI, Y. ; PORTER, K. A. ; AMEND, J. R. ; MARCHIORO, T L. ; ZULK, V. & STARZIN, T. E. - The preparation and testing of horse antidog and anti-human antilymphoid plasma or serum and its protein fractions. Surg. Gynec. & Obst. 124:1-24, 1967.

[9] 9. KUMAR, R. ; KLINE, I. K. & ABELMANN, W. H. - Immunosupprefion in experimental acute and sub-acute chagasic myocarditis. Am. J. Trop. Med. & Hyg. 19: 932-939, 1970.

[10] 10. LEVEY, R. H. & MEDAWAR, P. B. - Some experlments on the action of antilymphoid antisera. Ann. N. York Acad. Sei. 129: 164-177, 1966.

[11] 11. LUCKINS, A. G. - The effects of antilymphocyte serum and cycloohosphamide on the course of infection of T. brucei and T. congolense in rats and mice. Trans. Roy. Soc Trop. Med. & Hyg. 63: 423-42.4, 1969.

[12] 12. MEDAWAR, P. B. - Immunosuppressive agents with special reference to antilymphocytic serum. Proc. Roy. Soc. London. B. 174: 155-172, 1969

[13] 13. MENEZES, H. - Active immunization of dogs with a non virulent strain of Trypanosoma cruzi. Rev. Inst. Med. Trop. S. Paulo, 11: 258-263, 1969.

[14] 14. I - The avirulent of the cultivated Y strain of Trypanosoma cruzi. Rev. Inst. Med. Trop. S. Paulo, 12: 64-68, 1970.

[15] 15. II - The avirulence of the cultivated Y strain of Trypanosoma cruzi. Rev. Inst. Med. Trop. S. Paulo, 12: 129-135, 1970.

[16] 16. III - The avirulence of the cultivated Y strain of Trypanosoma cruzi. Rev. Inst. Med. Trop. S. Paulo, 13: 14-17, 1971.

[17] 17. The avirulence of the cultivated Y strain of Trypanosoma cruzi. IV - The effect of immunosuppressive agents in mice. Rev. Soc. Bras. Med. Trop. 6: 80-84, 1972.

[18] 18. MITCHISON, N. A. - Mechanism of action of antilymphocyte serum. Fed. Proceed. 29: 222-223. 1970.

[19] 19. STROTJT, R. G. - Method for concentrating hemoflagellates J. Parasit. 48: 100, 1962.

[20] 20. THIERMAN, J. E. & CHRISTEN, R. A. - Influencia del acetato de cortisona y de la aureomicina como agente agravador de la infection chagasica atenuada. Bol. inform. parasit. Chil 7: 5355, 1952.

[21] 21. VILCHES, A. M. ; KATZIN, A. ; GOLFERA, H. & SCHMUNIS, G. A. - The effect of heterologous anti-thymocyte serum upon the course of infection with Trypanosoma cruzi in mice, Tropenmed. Parasit. 24: 279-284, 1973.

[22] 22. WALKER P. J. - The virulence of infections of P. bergei and T. rhodesiense in animais Whose immune response has been impaired by radiation or antilymphocyte serum. J. Protozool. 15: 33, 1968. Supl.

[23] 23. WOODRUFF, M. F. A. & ANDERSON, N. F. - The effect of lymphocyte depletion by thoracic duct fistula and administration of anti-lymphocytic serum on survival of homographs in rats. Ann. N. York Acad. Sei. 120: 119-128, 1965.