Sobre o comportamento de duas linhagens de Schistosoma mansoni Sambon 1907: proposição para método de estudo quantitativo

Magalhães, Luiz A.; Carvalho, José F. de

doi:10.1590/S0037-86821976000400001

Resumos

Depois de tecerem comentários sobre as relações parasito-hospedeiro, os autores propõem um método para o estudo quantitativo de duas linhagens de Schistosoma mansoni. Após a proposição do método e sua aplicação, os autores concluem que a linhagem mineira de S. mansoni é mais patogênica do que a linhagem paulista do mesmo trematódeo.

After the commentaries made of host parasitic relations, the authors suggest method for the study of two strains of Schistosoma mansoni. With the rnethod proposed and its experimental use, the authors concluded. For both strains of S. mansoni, the average number of adult worms found m the host was 60 days after infection correlating positively with the number of cercarme whirh the host were exposed to. For both strains there was a positive correlation between the number of adult parasites found in the hosts 60 days after infection and the number of liver granuloma of the same hosts. For both the Belo Horizonte strain as to the São José dos Campos strain, a negative correlation was found between the number of liver granuloma and the average percentage of host survival. Over a certain number of adult parasites present, there was a significant percentual number of granuloma on the infected mice with the Belo Horizonte strain. Within limits there was a smaller significant percentual survivat of mice infected with the Belo Horizonte strain. For the same number of granuloma, survivat was not significantly different between infected host, by one or the other strain, therefore it is suggested that the hypothesis most likely, is that the pathogenecity of the Belo Horizonte strain results from larger number of granuloma per adult female present. Within the limits established for the host survival index and number of parasites, the band of the degree of pathogenecity ab keeps within close limit of each other for the two strains. Although for the São José dos Campos strain the number os parasites after the experiment was significantly greater, concluding that a smaller number of Beto Horizonte worms caused on the mice used in the experience, similar levels of pathogenecity and mortality, than a larger number of São José dos Campos worms.

Sobre o comportamento de duas linhagens de Schistosoma mansoni Sambon 1907. Proposição para método de estudo quantitativo

Luiz A. Magalhães^I; José F. de Carvalho^II

^IInstituto de Biologia da UNICAMP. Caixa Postal 1170. Campinas SSo Paulo

^IIInstituto de Ciências Matemáticas de SSo Carlos, USP, São Carlos, SP

RESUMO

Depois de tecerem comentários sobre as relações parasito-hospedeiro, os autores propõem um método para o estudo quantitativo de duas linhagens de Schistosoma mansoni. Após a proposição do método e sua aplicação, os autores concluem que a linhagem mineira de S. mansoni é mais patogênica do que a linhagem paulista do mesmo trematódeo.

ABSTRACT

After the commentaries made of host parasitic relations, the authors suggest method for the study of two strains of Schistosoma mansoni.

With the rnethod proposed and its experimental use, the authors concluded.

For both strains of S. mansoni, the average number of adult worms found m the host was 60 days after infection correlating positively with the number of cercarme whirh the host were exposed to.

For both strains there was a positive correlation between the number of adult parasites found in the hosts 60 days after infection and the number of liver granuloma of the same hosts.

For both the Belo Horizonte strain as to the São José dos Campos strain, a negative correlation was found between the number of liver granuloma and the average percentage of host survival.

Over a certain number of adult parasites present, there was a significant percentual number of granuloma on the infected mice with the Belo Horizonte strain.

Within limits there was a smaller significant percentual survivat of mice infected with the Belo Horizonte strain.

For the same number of granuloma, survivat was not significantly different between infected host, by one or the other strain, therefore it is suggested that the hypothesis most likely, is that the pathogenecity of the Belo Horizonte strain results from larger number of granuloma per adult female present.

Within the limits established for the host survival index and number of parasites, the band of the degree of pathogenecity ab keeps within close limit of each other for the two strains. Although for the São José dos Campos strain the number os parasites after the experiment was significantly greater, concluding that a smaller number of Beto Horizonte worms caused on the mice used in the experience, similar levels of pathogenecity and mortality, than a larger number of São José dos Campos worms.

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Trabalho realizado com o auxilio do Conselho Nacional de Pesquisas (CNPq)

1. BRENER, Z. - Observações sobre a infecção do camundongo pelo Schistosoma mansoni. Rev. Bras. Malariol. Doenç. Trop., 8: 565-575, 1956.
2. BRENER, Z. - Contribuição ao estudo da terapêutica experimental da esquistossomose mansônica. Tese de Cátedra. Belo Horizonte, 1962.
3. BRENER, Z.; PELLEGRINO, J. & OLIVEIRA, F.C. - Terapêutica experimental da esquistossomose mansoni. Aplicação do método de isolamento de granulomas do fígado de camundongos. Rev. Bras. Malariol, Doenç. Trop., 8: 583-587, 1956.
4. CLEGG, J.A. & SMITHERS, J.R. - Death of schistosomose cercariae during penetration of. the skin: II - Penetration of mammalian skin by S. mansoni. Parasitology, 58: 111-128, 1968.
5. HILL, J. - Chemoterapeutic studies with laboratory infections of Schistosoma mansoni. Ann. Trop. Med. Parasit, 50: 39-48, 1956.
6. KUNTZ, R.E.; MALAKATIS, G.M. & WELLS, W.H. - Susceptibility of laboratory animais to infection by the egyptian strain of Schistosoma mansoni with emphasis on the albino mouse. Comptes Rendus V Congr. Intern. Med. Trop. Palud., 2:374, 1953.
7. LINNAEUS, C. - Systema nature per régua tria naturae secundum classes, ordinies, genera, species, cum characteribus, differentitiis, synonymis, locis. Editio decima, reformata, 1758.
8. MAGALHÃES, L.A. - Moluscos planorbfdeos do Distrito Federal, Brasília. Tese de Doutoramento apresentada à Universidade Estadual de Campinas, 1967.
9. MAGALHÃES, L.A. & CARVALHO, J.F. - Verificação do número de machos e fêmeas de Schistosoma mansoni capturados em camundongos infectados por duas cepas do helminto. Rev. Soc. Bras. Med. Trop. 5: 253-254, 1969.
10. MOORE, D.V.; YOLLES, T. K. & MELENEY, H. - A comparison of common laboratory animais as experimental hosts for Schistosoma mansoni J. Parasit.. 35: 156-170, 1949.
11. MOURA, S.A.L. - Esquistossomose mansoni autóctone em Santos. Rev. Inst. Adolfo Lutz, 5: 279-311, 1945.
12. ORBIGNY, A. - Synopsis terrestrim et fluviatilium molluscarum in suo per Ameri can Meridionalem itinere collectorum. Mag. Zool. 5^o année, 62: 26-28, 1837.
13. PARAENSE, W.L. & CORRÊA, L.R. - Sobre a ocorrência de duas raças biológicas do Schistosoma mansoni no Brasil. Ciên. Cult. 15: 245-246, 1963.
14. PAVLOVSKY, E.N. - Natural Nidality of transmissible diseases. Peace Publishers. Moscow, sem data.
15. PELLEGRINO, J. & BRENER, Z. - Method for isolating schistosomose granulomas from mouse liver. J. Parasit, 42: 564, 1956.
16. PELLEGRINO, J. & KATZ, N. - Infection of baby mice with S. mansoni: some aspects in connection with experimental chemotherapy. Trans. Roy. Soc. Trop. Med. Hyg. 63: 568-575, 1969.
17. PIZA, J.T.; RAMOS, A.S.; BRANDÃO, C.S.H. & FIGUEIREDO, C.G. - A esquistossomose no Vale do Paraíba (Estado de SSão Paulo - Brasil). Observações sobre a doença em alguns municípios e a fauna planorbídica da região. Rev. Inst. Adolfo Lutz, 19: 97-143, 1959.
18. PIZA, J.T. & RAMOS, A.S. - Os focos autóctones de esquistosomose no estado de São Paulo. Arq. Hig. Saúde Públ. São Paulo, 25: 261-271, 1960.
19. RAILLET, A. - Traité de zoologie médícale et agricole. 2nd. ed. Paris, 1895.
20. SAY, T. - Account of two genera and several species of fresh water and land shells. J. Acad. Nat. Sei. Philadelphia. 1: 276-284, 1818.
21. STANDEN, O.D. - The relationship of sex in Schistosoma mansoni to migration within the hepatic port system of experimentally infected mice. Ann. Trop. Med. Parasit. 47:139-145, 1953.

Datas de Publicação

Publicação nesta coleção
12 Jun 2013
Data do Fascículo
Ago 1976

Histórico

Aceito
28 Abr 1976
Recebido
28 Abr 1976

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. BRENER, Z. - Observações sobre a infecção do camundongo pelo Schistosoma mansoni. Rev. Bras. Malariol. Doenç. Trop., 8: 565-575, 1956.

[2] 2. BRENER, Z. - Contribuição ao estudo da terapêutica experimental da esquistossomose mansônica. Tese de Cátedra. Belo Horizonte, 1962.

[3] 3. BRENER, Z.; PELLEGRINO, J. & OLIVEIRA, F.C. - Terapêutica experimental da esquistossomose mansoni. Aplicação do método de isolamento de granulomas do fígado de camundongos. Rev. Bras. Malariol, Doenç. Trop., 8: 583-587, 1956.

[4] 4. CLEGG, J.A. & SMITHERS, J.R. - Death of schistosomose cercariae during penetration of. the skin: II - Penetration of mammalian skin by S. mansoni. Parasitology, 58: 111-128, 1968.

[5] 5. HILL, J. - Chemoterapeutic studies with laboratory infections of Schistosoma mansoni. Ann. Trop. Med. Parasit, 50: 39-48, 1956.

[6] 6. KUNTZ, R.E.; MALAKATIS, G.M. & WELLS, W.H. - Susceptibility of laboratory animais to infection by the egyptian strain of Schistosoma mansoni with emphasis on the albino mouse. Comptes Rendus V Congr. Intern. Med. Trop. Palud., 2:374, 1953.

[7] 7. LINNAEUS, C. - Systema nature per régua tria naturae secundum classes, ordinies, genera, species, cum characteribus, differentitiis, synonymis, locis. Editio decima, reformata, 1758.

[8] 8. MAGALHÃES, L.A. - Moluscos planorbfdeos do Distrito Federal, Brasília. Tese de Doutoramento apresentada à Universidade Estadual de Campinas, 1967.

[9] 9. MAGALHÃES, L.A. & CARVALHO, J.F. - Verificação do número de machos e fêmeas de Schistosoma mansoni capturados em camundongos infectados por duas cepas do helminto. Rev. Soc. Bras. Med. Trop. 5: 253-254, 1969.

[10] 10. MOORE, D.V.; YOLLES, T. K. & MELENEY, H. - A comparison of common laboratory animais as experimental hosts for Schistosoma mansoni J. Parasit.. 35: 156-170, 1949.

[11] 11. MOURA, S.A.L. - Esquistossomose mansoni autóctone em Santos. Rev. Inst. Adolfo Lutz, 5: 279-311, 1945.

[12] 12. ORBIGNY, A. - Synopsis terrestrim et fluviatilium molluscarum in suo per Ameri can Meridionalem itinere collectorum. Mag. Zool. 5^o année, 62: 26-28, 1837.

[13] 13. PARAENSE, W.L. & CORRÊA, L.R. - Sobre a ocorrência de duas raças biológicas do Schistosoma mansoni no Brasil. Ciên. Cult. 15: 245-246, 1963.

[14] 14. PAVLOVSKY, E.N. - Natural Nidality of transmissible diseases. Peace Publishers. Moscow, sem data.

[15] 15. PELLEGRINO, J. & BRENER, Z. - Method for isolating schistosomose granulomas from mouse liver. J. Parasit, 42: 564, 1956.

[16] 16. PELLEGRINO, J. & KATZ, N. - Infection of baby mice with S. mansoni: some aspects in connection with experimental chemotherapy. Trans. Roy. Soc. Trop. Med. Hyg. 63: 568-575, 1969.

[17] 17. PIZA, J.T.; RAMOS, A.S.; BRANDÃO, C.S.H. & FIGUEIREDO, C.G. - A esquistossomose no Vale do Paraíba (Estado de SSão Paulo - Brasil). Observações sobre a doença em alguns municípios e a fauna planorbídica da região. Rev. Inst. Adolfo Lutz, 19: 97-143, 1959.

[18] 18. PIZA, J.T. & RAMOS, A.S. - Os focos autóctones de esquistosomose no estado de São Paulo. Arq. Hig. Saúde Públ. São Paulo, 25: 261-271, 1960.

[19] 19. RAILLET, A. - Traité de zoologie médícale et agricole. 2nd. ed. Paris, 1895.

[20] 20. SAY, T. - Account of two genera and several species of fresh water and land shells. J. Acad. Nat. Sei. Philadelphia. 1: 276-284, 1818.

[21] 21. STANDEN, O.D. - The relationship of sex in Schistosoma mansoni to migration within the hepatic port system of experimentally infected mice. Ann. Trop. Med. Parasit. 47:139-145, 1953.

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Sobre o comportamento de duas linhagens de Schistosoma mansoni Sambon 1907: proposição para método de estudo quantitativo

Resumos

Datas de Publicação

Histórico