SciELO - Scientific Electronic Library Online

 
vol.16 issue1Esofagopatia chagásica na área endêmica de Bambuí - M.G., Brasil author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

Share


Revista da Sociedade Brasileira de Medicina Tropical

Print version ISSN 0037-8682

Rev. Soc. Bras. Med. Trop. vol.16 no.1 Uberaba Jan./Mar. 1983

http://dx.doi.org/10.1590/S0037-86821983000100008 

ARTICLES

 

Effects of lethal and non-lethal malaria on the mononuclear phagocyte system*

 

 

Carlos Eduardo TostaI; Greta Ruiz; Nina Wedderburn

IPresent address: Departamento de Medicina Complementar, Universidade de Brasflia, 70.910 Brasília, Brasil

 

 


ABSTRACT

The effects ofone non-lethal species ofmalarialparasite, Plasmodium yoelii, and one lethal species, P. berghei, on the mononuclear phagocyte system (MPS) of BALB/c mice were studied. P. yoelii caused a greater and more sustained expansion and activation of the MPS, and the two major populations of spleen phagocytic cells-red pulp and marginal zone macrophages — exhibited a greater increase in numbers in this infection. During the course of P. berghei mataria, the spleen was progressively occupied by haematopoietic tissue and, at the terminal stage of infection, an extensive depletion of lymphocytes and macrophages was apparent.
The possibility was suggested that the outcome of mataria may be inftuenced by the particular way the parasite interacts with the MPS.

Keywords: Malaria. Plasmodium yoelii. Plasmodium berghei. Mononuclear phagocyte System. Macrophages. Monocytes. BALB/c mice


RESUMO

Estudou-se o efeito da infecção causada por espécie letal (Plasmodium berghei) e não- letal (P. yoelii) de plasmódio sobre o sistema de fagócitos mononucleares de camundongo BALB/c. O P. yoelii causou maior e mais prolongada expansão e ativação do sistema de macrófagos. As duas mais importantes populações de fagócitos esplênicos — macrófagos de polpa vermelha e da zona marginal — exibiam maior aumento do número de células nesta infecção. Durante a evolução da malária por P. berghei, o baço foi progressivamente ocupado por tecido hematopoiético e, na fase terminal da infecção, observou-se significativa depleção dos linfócitos e macrófagos esplênicos. Os dados apresentados indicam que a evolução da malária depende do tipo de interação entre o plasmódio e o sistema de fagócitos mononucleares.

Palavras-chave: Malária. Plasmodium yoelii. Plasmodium berghei. Sistema de fagócitos mononucleares. Macrófagos. Camundongos BALB/c.


 

 

Full text available only in PDF format.

Texto completo disponível apenas em PDF.

 

 

REFERENCES

1. Brissette WH, Coleman RM, Rencricca NJ Depressed splenic T lymphocyte numbers and thymocyte migratory patterns in murine malaria. Proceedings of the Society for Experimental Biology and Medicine 159: 317-320, 1978.         [ Links ]

2. Brown KN, Brown IN, Trigg PI, Phillips RS, Hills LA. Immunity to malaria. II. Serological response of monkeys sensitized by dead parasitized cells in Freund's complete adjuvant. Experimental Parasitology 28:318-338, 1970.         [ Links ]

3. Deinmann W, Fahimi HD. The appearance of transition forms between monocytes and Kupffer cells in the liver of rats treated with glucan. A cytochemical and ultrastructural study. Journal of Experimental Medicine 149:883-897, 1979.         [ Links ]

4. de Souza M. Lymphoid cell positioning: a new proposal for the mechanisms of control of lymphoid cell migration. In: Cell- 66 cell recognition, Symposium n9 32, Society for Experimental Biology, p 393-409, Cambridge University Press, Cambridge, 1978.         [ Links ]

5. Disbrey RD, Rack JH. Histological laboratory methods. E & S Livingstone, Edinburgh, 1970.         [ Links ]

6. Frankenburg S, Londner MV, Greenblatt CL. Cellular changes in the bone marrow of Plasmodium berghei-infected mice. II. Blast transformation and phagocytosis. Cellular Immunology 55:185-190, 1980.         [ Links ]

7. Freoman RR, Parish CR. Spleen cell changes during fatal and self-limiting malarial infections of mice. Immunology 35:479- 484, 1978.         [ Links ]

8. Horwitz DA, Allison AC, Ward P, Knight N - Identification of human mononuclear leucocyte populations by esterase staining. Clinical and Experimental Immunology 30:289-298, 1977.         [ Links ]

9. Humphrey JL. Marginal zone and marginal sinus macrophages in the mouse are distinct populations. Advances in Experimental Medicine and Biology 114:381-388, 1979.         [ Links ]

10. Humnhrey JL. Macrophages and the differential migration of lymphocytes. In: Blood cells and vessel walls: functional interactions. Ciba Symposíum n9 71, p 287-296, Ciba Foundation, London, 1980.         [ Links ]

11. Kelly LS, Brown BA, Dobson EL. Cell division and phagocytic activity in the liver reticulo-endothelial cells. Proceedings of the Society for Experimental Biology and Medicine 110:555-559, 1962.         [ Links ]

12. Lelchuk R, Playfair JHL. Two distinct types of non-specific immunosuppression in murine malaria. Clinical and Experimental Immunology 42:428-435, 1980.         [ Links ]

13. North RJ. Cellular kineties associated with the development of acquired cellular resistance. Journal of Experimental Medicine 130299-311, 1969.         [ Links ]

14. Rabinovitch M, de Stefano MJ. Macrophage spreading in vitro. I. Inducers of spreading. Experimental Cell Research 77:323- 334, 1973.         [ Links ]

15. Rhodes JM, Bennedsen J, Riisgaard S, Larsen SO. Intracellular killing, degradation, metabolic activity, and increase in betagalactosidase activity as markers for activated macrophages. In: R van Furth (ed) Mononuclear phagocytes. Functional aspects. Martinus Nijhoff, The Hague, p 1743-1757, 1980.         [ Links ]

16. Shear HL, Nussenzweig RS, Bianco C. Immune phagocytosis in murine malaria. Journal of Experimental Medicine 149: 1288-1298, 1979.         [ Links ]

17. Singer I. The cellular reactions to infections with Plasmodium berghei in the white mouse. Journal of Infectious Diseases 94: 241-261, 1954.         [ Links ]

18. Taliaferro WH, Mulligan HW. The histopathology of malaria with special reference to the function and origin of the macrophages in defence. Indian Medical Research Memories 29:1-138, 1937.         [ Links ]

19. van Furth R, Diesselhoffden Dulk MMC, Raeburn JA, van Zwet TL, van Oud Alblas AB. Characteristics, origin and kineties of human and murine mononuclear phagocytes. In: R van Furth |ed) Mononuclear phagocytes. Functional aspects. Martinus Nijhoff, The Hague, p 279-298, 1980.         [ Links ]

20. Widmann JJ, Cotran RS, Fahimi HD.Mononuclear phagocytes (Kupffer cells) and endothelial cells: identification of two functional cell types in rat liver sinusoids by endogenous peroxidase activity. Journal of Cell Biology 52:159-170, 1972.         [ Links ]

21. Wyler DJ. Cellular aspects of immunoregulation in malaria. Bulletin of the World Health Organization 57:239-243, 1979.         [ Links ]

22. Wyler DJ, Gallin Jl. Spleen-derived mono-nuclear cell chemotactic factor in malaria infections: a possible mechanism for splenic macrophage accumulation. The Journal of Immunology 118:478-484, 1977.         [ Links ]

 

 

Recebido para publicação em 03/01/83.

 

 

* Work from the Department of Pathology, Institute of Basic Medical Sciences, London, England, supported by grants from the Cancer Research Campaign of the United Kingdom and Conselho Nacional de Desenvolvimento Cientifico e Tecnológico, Brasil.

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License