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Revista da Sociedade Brasileira de Medicina Tropical

Print version ISSN 0037-8682

Rev. Soc. Bras. Med. Trop. vol.16 no.1 Uberaba Jan./Mar. 1983 



Effects of lethal and non-lethal malaria on the mononuclear phagocyte system*



Carlos Eduardo TostaI; Greta Ruiz; Nina Wedderburn

IPresent address: Departamento de Medicina Complementar, Universidade de Brasflia, 70.910 Brasília, Brasil




The effects ofone non-lethal species ofmalarialparasite, Plasmodium yoelii, and one lethal species, P. berghei, on the mononuclear phagocyte system (MPS) of BALB/c mice were studied. P. yoelii caused a greater and more sustained expansion and activation of the MPS, and the two major populations of spleen phagocytic cells-red pulp and marginal zone macrophages — exhibited a greater increase in numbers in this infection. During the course of P. berghei mataria, the spleen was progressively occupied by haematopoietic tissue and, at the terminal stage of infection, an extensive depletion of lymphocytes and macrophages was apparent.
The possibility was suggested that the outcome of mataria may be inftuenced by the particular way the parasite interacts with the MPS.

Keywords: Malaria. Plasmodium yoelii. Plasmodium berghei. Mononuclear phagocyte System. Macrophages. Monocytes. BALB/c mice


Estudou-se o efeito da infecção causada por espécie letal (Plasmodium berghei) e não- letal (P. yoelii) de plasmódio sobre o sistema de fagócitos mononucleares de camundongo BALB/c. O P. yoelii causou maior e mais prolongada expansão e ativação do sistema de macrófagos. As duas mais importantes populações de fagócitos esplênicos — macrófagos de polpa vermelha e da zona marginal — exibiam maior aumento do número de células nesta infecção. Durante a evolução da malária por P. berghei, o baço foi progressivamente ocupado por tecido hematopoiético e, na fase terminal da infecção, observou-se significativa depleção dos linfócitos e macrófagos esplênicos. Os dados apresentados indicam que a evolução da malária depende do tipo de interação entre o plasmódio e o sistema de fagócitos mononucleares.

Palavras-chave: Malária. Plasmodium yoelii. Plasmodium berghei. Sistema de fagócitos mononucleares. Macrófagos. Camundongos BALB/c.



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Recebido para publicação em 03/01/83.



* Work from the Department of Pathology, Institute of Basic Medical Sciences, London, England, supported by grants from the Cancer Research Campaign of the United Kingdom and Conselho Nacional de Desenvolvimento Cientifico e Tecnológico, Brasil.

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