Leishmania mexicana: aspectos taxonómicos y rareza de la infección humana en Três Braços, Bahia, Brasil

Cuba, César Augusto Cuba; Barreto, Air Colombo; Marsden, Philip Davis

doi:10.1590/S0037-86821984000300002

Resúmenes

Del estúdio de 51 stocks de Leishmania aislados de pacientes humanos de leishmaniasis cutaneomucosa en Três Braços, Bahia, Brasil, los autores describen, en detalle, el análisis de los dos únicos stocks de L. mexicana, identificando uno de ellos como L. mexicana amazonensis. El otro aislado permanece en posición taxonómica no definida pues considerándosele como un miembro de L. mexicana, encuéntranse dificultades para su identificación subespecífica. Evaluan también los parâmetros biológicos e isoenzimáticos y discuten el papel de los anticuerpos monoclonales en la tipificación de éstos stocks. Los autores remarcan la rareza de la transmisión de parásitos del complejo L. mexicana en esta región, aun cuando estudien epidemiológicamente por mais de 8 anos la infección humana.

Leishmania mexicana. L. mexicana amazonensis; Transmisión humana; Aspectos taxonómicos

In a study of 51 stocks of Leishmania isolated from patients with cutaneous leishmaniasis in Três Braços, Bahia, Brazil 49 were characterized as L. braziliensis braziliensis. Only two L. mexicana stocks were identified. One was subspeciated as L. mexicana amazonensis. The other differed from this species and to date remains unspeciated. The biological parameters, isoenzyme analysis and monoclonal antibody findings relating to these two strains are discussed. Transmission of parasites of the mexicana complex to man have been rare in this region during the 8 years of study of the human infection.

Leishmania mexicana L. mexicana amazonensis; Human transmission; Taxonomic aspects

ARTÍCULOS

Leishmania mexicana: aspectos taxonómicos y rareza de la infección humana en Três Braços, Bahia, Brasil¹ 1 Trabajo parcialmente financiado por el CNPq PIDE V 403682 y WHO/TDR-RE. Grant Special Programme for Research and Training in Tropical Diseases.

César Augusto Cuba Cuba; Air Colombo Barreto; Philip Davis Marsden^I

^IFaculdade de Ciências da Saúde e Núcleo de Medicina Tropical - Universidade de Brasília - Brasília - DF - Brasil

RESUMEN

Del estúdio de 51 stocks de Leishmania aislados de pacientes humanos de leishmaniasis cutaneomucosa en Três Braços, Bahia, Brasil, los autores describen, en detalle, el análisis de los dos únicos stocks de L. mexicana, identificando uno de ellos como L. mexicana amazonensis. El otro aislado permanece en posición taxonómica no definida pues considerándosele como un miembro de L. mexicana, encuéntranse dificultades para su identificación subespecífica. Evaluan también los parâmetros biológicos e isoenzimáticos y discuten el papel de los anticuerpos monoclonales en la tipificación de éstos stocks. Los autores remarcan la rareza de la transmisión de parásitos del complejo L. mexicana en esta región, aun cuando estudien epidemiológicamente por mais de 8 anos la infección humana.

Palabras-clave:Leishmania mexicana. L. mexicana amazonensis. Transmisión humana. Aspectos taxonómicos.

ABSTRACT

In a study of 51 stocks of Leishmania isolated from patients with cutaneous leishmaniasis in Três Braços, Bahia, Brazil 49 were characterized as L. braziliensis braziliensis. Only two L. mexicana stocks were identified. One was subspeciated as L. mexicana amazonensis. The other differed from this species and to date remains unspeciated. The biological parameters, isoenzyme analysis and monoclonal antibody findings relating to these two strains are discussed. Transmission of parasites of the mexicana complex to man have been rare in this region during the 8 years of study of the human infection.

Keywords:Leishmania mexicanaL. mexicana amazonensis Human transmission. Taxonomic aspects.

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1. Barreto AC, Peterson N, Rosa AC, Cuba CC, Vexenat JA, Marsden PD. Caracterização de estoques de Leishmania isolados de cão e de roedor (Proechimys inheringi denigratus) da região sudeste da Bahia, através de anticorpos monoclonais. XI Congresso da Sociedade Brasileira de Medicina Tropical, Salvador, Bahia, 1984.
2. Bradley DJ. Genetic control of natural resistence to Leishmania donovani infection. Nature 283: 72-73, 1974.
3. Cuba CA, Vexenat AJ, Llanos EA, Marsden PD, Barreto AC, Rosa AC. Experimental infections of wild caught specimens of Lutzomyia (N) whitmani (Diptera. Psychodidae) and their use for Leishmania Identification. IX Reunião Anual de Pesquisa Básica em Doença de Chagas, Caxambu, MG, p. 89, 1982.
4. Cuba CA. Leishmaniose tegumentar em área endęmica do Estado da Bahia, Brasil. Caracterização e classificação de Leishmania do homem e do cão doméstico e aspectos comportamentais de L. braziliensis braziliensis Tese de Doutorado. Universidade Federal de Minas Gerais, Belo Horizonte, MG, 1983.
5. Godfrey DG. Biochemical characterization in the taxonomy of parasitic Protozoa. In: Biochemical characterization of Leishmania Proceedings of a Workshop Pan American Health Organization, Washington, D.C., December 1980, pp. 63-71, 1982.
6. Lainson R, Shaw JJ. Leishmania and Leishmaniasis of the New World, with particular reference to Brazil. Bulletin of the Pan American Health Organization, 7: 1-19, 1973.
7. Lainson R, Ward RD, Shaw JJ. Leishmania in flebo tomid sandflies VI. Importance of hindgut development in distinguishing between parasites of the Leishmania mexicana and L. braziliensis complexes. Proceedings of the Royal Society 199: 309-320, 1977.
8. Lainson R, Shaw JJ. The role of animals in the epidemiology of South American leishmaniasis. In: Biology of Kinetoplastida. Vol. II Lumsden WHR & Evans, D.A. (eds). Academic Press, London, pp. 1-116, 1979.
9. Lainson R. Epidemiologia e ecologia de leishmaniose tegumentar na Amazônia. Hiléia Médica, Belém 3: 35-40, 1981.
10. Lainson R. The American Leishmaniases: some observations on their ecology and epidemiology. Transactions of the Royal Society of Tropical Medicine & Hygiene 77: 569-596, 1983.
11. Marsden P, Cuba CC, Barreto AC, Sampaio RN, Rocha RAA. Nifurtimox in the treatment of South American Leishmaniasis. Transactions of the Royal Society of Tropical Medicine & Hygiene 75: 556-559, 1979.
12. Mc Mahon-Pratt D, David JR. Monoclonal antibodies that distinguish between New World species of Leishmania Nature 291: 581-583, 1981.
13. Miles MA, Povoa MM, Souza AA, Lainson R, Shaw JJ. Some methods for the enzymic characterization of Latin American Leishmania with particular reference to Leishmania mexicana amazonensis and subspecies of Leishmania hertigi Transactions of the Royal Society of Tropical Medicine & Hygiene 74: 243-252, 1980.
14. Mayrink W, Williams P, Coelho MV, Dias M, Vianna Martins A, Magalhães PA, Da Costa CA, Falcão AR, Mello MN, Falcão AL. Epidemiology of dermal leishmaniasis in the Rio Doce Valley State of Minas Gerais, Brazil. Annals of Tropical Medicine and Parasitology 73: 123-137, 1979.
15. Perez H. Factors influencing the host response to Leishmania mexicana In: Cytopathology of parasitic disease. Pitman Books, London Ciba Foundation Symposium 99, pp. 157-173, 1983.
16. Shaw JJ, Lainson R Leishmaniasis in Brasil. XI Observations on the morphology of Leishmania of the braziliensis and mexicana complexes. Journal of Tropical Medicine and Hygiene 79: 9-13, 1976.
17. Shaw JJ. Taxonomy of the Genus Leishmania: Traditionalist's view and modem concepts. In: Biochemichal characterization of Leishmania Proceedings of a Workshop, Pan American Health Organization, Washington, pp. 9-24, 1982.
18. Walton BC, Intermill RW, Hajduk ME. Differences in biological characteristics of three Leishmania isolates from patients with espundia. American Journal of Tropical Medicine and Hygiene 26: 850-855, 1977.
19. Walton BC, Shaw JJ, Lainson R. Observations on the in vitro cultivation of Leishmania braziliensis The Journal of Parasitology 63: 1118-1119, 1977.
20. Ward RD, Lainson R, Shaw JJ. Some methods for membrane feeding of laboratory reared neotropical sandflies (Diptera, Psychodidae). Annals of Tropical Medicine and Parasitology 72: 269-276, 1978.

1

Trabajo parcialmente financiado por el CNPq PIDE V 403682 y WHO/TDR-RE. Grant Special Programme for Research and Training in Tropical Diseases.

Fechas de Publicación

Publicación en esta colección
07 Jun 2013
Fecha del número
Set 1984

Histórico

Acepto
18 Jul 1984
Recibido
18 Jul 1984

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. Barreto AC, Peterson N, Rosa AC, Cuba CC, Vexenat JA, Marsden PD. Caracterização de estoques de Leishmania isolados de cão e de roedor (Proechimys inheringi denigratus) da região sudeste da Bahia, através de anticorpos monoclonais. XI Congresso da Sociedade Brasileira de Medicina Tropical, Salvador, Bahia, 1984.

[2] 2. Bradley DJ. Genetic control of natural resistence to Leishmania donovani infection. Nature 283: 72-73, 1974.

[3] 3. Cuba CA, Vexenat AJ, Llanos EA, Marsden PD, Barreto AC, Rosa AC. Experimental infections of wild caught specimens of Lutzomyia (N) whitmani (Diptera. Psychodidae) and their use for Leishmania Identification. IX Reunião Anual de Pesquisa Básica em Doença de Chagas, Caxambu, MG, p. 89, 1982.

[4] 4. Cuba CA. Leishmaniose tegumentar em área endęmica do Estado da Bahia, Brasil. Caracterização e classificação de Leishmania do homem e do cão doméstico e aspectos comportamentais de L. braziliensis braziliensis Tese de Doutorado. Universidade Federal de Minas Gerais, Belo Horizonte, MG, 1983.

[5] 5. Godfrey DG. Biochemical characterization in the taxonomy of parasitic Protozoa. In: Biochemical characterization of Leishmania Proceedings of a Workshop Pan American Health Organization, Washington, D.C., December 1980, pp. 63-71, 1982.

[6] 6. Lainson R, Shaw JJ. Leishmania and Leishmaniasis of the New World, with particular reference to Brazil. Bulletin of the Pan American Health Organization, 7: 1-19, 1973.

[7] 7. Lainson R, Ward RD, Shaw JJ. Leishmania in flebo tomid sandflies VI. Importance of hindgut development in distinguishing between parasites of the Leishmania mexicana and L. braziliensis complexes. Proceedings of the Royal Society 199: 309-320, 1977.

[8] 8. Lainson R, Shaw JJ. The role of animals in the epidemiology of South American leishmaniasis. In: Biology of Kinetoplastida. Vol. II Lumsden WHR & Evans, D.A. (eds). Academic Press, London, pp. 1-116, 1979.

[9] 9. Lainson R. Epidemiologia e ecologia de leishmaniose tegumentar na Amazônia. Hiléia Médica, Belém 3: 35-40, 1981.

[10] 10. Lainson R. The American Leishmaniases: some observations on their ecology and epidemiology. Transactions of the Royal Society of Tropical Medicine & Hygiene 77: 569-596, 1983.

[11] 11. Marsden P, Cuba CC, Barreto AC, Sampaio RN, Rocha RAA. Nifurtimox in the treatment of South American Leishmaniasis. Transactions of the Royal Society of Tropical Medicine & Hygiene 75: 556-559, 1979.

[12] 12. Mc Mahon-Pratt D, David JR. Monoclonal antibodies that distinguish between New World species of Leishmania Nature 291: 581-583, 1981.

[13] 13. Miles MA, Povoa MM, Souza AA, Lainson R, Shaw JJ. Some methods for the enzymic characterization of Latin American Leishmania with particular reference to Leishmania mexicana amazonensis and subspecies of Leishmania hertigi Transactions of the Royal Society of Tropical Medicine & Hygiene 74: 243-252, 1980.

[14] 14. Mayrink W, Williams P, Coelho MV, Dias M, Vianna Martins A, Magalhães PA, Da Costa CA, Falcão AR, Mello MN, Falcão AL. Epidemiology of dermal leishmaniasis in the Rio Doce Valley State of Minas Gerais, Brazil. Annals of Tropical Medicine and Parasitology 73: 123-137, 1979.

[15] 15. Perez H. Factors influencing the host response to Leishmania mexicana In: Cytopathology of parasitic disease. Pitman Books, London Ciba Foundation Symposium 99, pp. 157-173, 1983.

[16] 16. Shaw JJ, Lainson R Leishmaniasis in Brasil. XI Observations on the morphology of Leishmania of the braziliensis and mexicana complexes. Journal of Tropical Medicine and Hygiene 79: 9-13, 1976.

[17] 17. Shaw JJ. Taxonomy of the Genus Leishmania: Traditionalist's view and modem concepts. In: Biochemichal characterization of Leishmania Proceedings of a Workshop, Pan American Health Organization, Washington, pp. 9-24, 1982.

[18] 18. Walton BC, Intermill RW, Hajduk ME. Differences in biological characteristics of three Leishmania isolates from patients with espundia. American Journal of Tropical Medicine and Hygiene 26: 850-855, 1977.

[19] 19. Walton BC, Shaw JJ, Lainson R. Observations on the in vitro cultivation of Leishmania braziliensis The Journal of Parasitology 63: 1118-1119, 1977.

[20] 20. Ward RD, Lainson R, Shaw JJ. Some methods for membrane feeding of laboratory reared neotropical sandflies (Diptera, Psychodidae). Annals of Tropical Medicine and Parasitology 72: 269-276, 1978.