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Revista da Sociedade Brasileira de Medicina Tropical

Print version ISSN 0037-8682

Rev. Soc. Bras. Med. Trop. vol.19 no.1 Uberaba Jan./Mar. 1986

http://dx.doi.org/10.1590/S0037-86821986000100009 

ARTICLES

 

Evolution of sarcoma 180 (ascitic tumor) in mice infected with Schistosoma mansoni

 

 

Fausto Edmundo Lima PereiraI; Pedro RasoII; Paulo Marcos Zech CoelhoII

IDepartamento de Patologia Centro Biomédico UFES. Caixa Postal 780-29000 - Vitória - E. Santo - Brasil
IIGrupo Integrado de Pesquisa em Esquistossomose ICB- UFMG

Adress to correspondence

 

 


ABSTRACT

Mice infected with 60 cercariae of Schistosoma mansoni were more resistant to the sarcoma 180 ascites tumor. Tumor inoculation was performed 50 days after schistosoma infection and the animals were observed and weighed at 48 hours intervals for development and progression of malignancy. In infected mice the weight gain (ascites formation) started later and was shorter than in uninfected Controls. Also, the number of tumor cells into the peritoneal cavity 72h after tumor implantation was shorter in infected group than incontrols. This in creased resistance against a transplantable tumor probably is related to the effect of endotoxin on tumoricidal activity of macrophages activated by the infection. The immunodepression induced by Schistosoma mansoni infection enhances the proliferation of endogenous bacteria increasing the amount of endotoxin absorbed from the gut.

Keywords: Experimental Schistosomiasis. Sarcoma 180. Schistosomiasis and cancer.


RESUMO

Camundongos infectados com 60 cercárias de Schistosoma mansoni tomaram-se mais resistentes ao sarcoma 180 na forma de tumor ascítico. A inoculação das células tumorais foi feita no 50o dia de infecção e a evolução do tumor foi acompanhada através dapesagem dos animais com intervalos de 48 horas. Nos camundongos infectados o ganho de peso (formação da ascite) começou mais tarde e foi menor do que nos controles não infectados. Também o número de células tumorais na cavidade peritoneal 72 horas após a implantação do tumor foi menor no grupo infectado. Este aumento de resistência a um tumor transplantávelpossivelmente está relacionado ao efeito de endotoxinas sobre a atividade tumoricida dos macrofagos ativados pela infecção. A imunossupressão induzida pela infecção favorece a proliferação de bactérias da flora endógena aumentando a quantidade de endotoxinas absorvidas pelo intestino.

Palavras-chave: Esquistossomose experimental. Sarcoma 180. Esquistossomose e Câncer.


 

 

Full text available only in PDF format.

Texto completo disponível apenas em PDF.

 

 

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Endereço para correspondência:
Fausto Edmundo Lima Pereira
Depto de Patologia
Centro Biomédico da Universidade Federal do Espírito Santo
Caixa Postal 780
29000
Vitória - E. Santo. Brasil.

 

 

Recebido para publicação em 19/8/1985.

 

 

This work was supported by CNPq and FINEP.

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