T cell-dependent immunodepression in vivo in Schistosoma mansoni infected patients

Muniz-Junqueira, Maria Imaculada; Tosta, Carlos Eduardo; Prata, Aluizio

doi:10.1590/S0037-86821990000100005

Abstracts

T-cell function was evaluated in 29 patients with either hepatointestinal or hepatosplenic schistosomiasis by intradermal tests to recall antigens. Immunodepression was detected in 26% of the subjects with hepatointestinal schistosomiasis and in 50% of those with the hepatosplenic form. Cellular immunodepression was related to worm load and spleen size. This non specific T-cell immunodepression may represent a serious constraint to the elimination of intracellular pathogens both in hepatosplenic or hepatointestinal schistosomiasis.

Schistosomiasis; T-cell dependent immunodepression

A imunidade celular foi avaliada em 29 pacientes com as formas hepatoesplênica ou hepatointestinal, da esquistossomose mansoni, através de testes intradérmicos com antígenos não relacionados ao Schistosoma. Imunodepressão foi detectada em 26% dos pacientes com a forma hepatointestinal e em 50% daqueles com a forma hepatoesplênica. A imunodepressão celular foi relacionada com a carga parasitária e o tamanho do baço. Esta imunodepressão celular pode dificultar a eliminação de patógenos intracelulares tanto na forma hepatoesplênica quanto na forma hepatointestinal da esquistossomose.

Esquistossomose; Imunodepressão celular

ARTICLES

T cell-dependent immunodepression in vivo in Schistosoma mansoni infected patients

Maria Imaculada Muniz-Junqueira; Carlos Eduardo Tosta; Aluizio Prata

^{Adress to correspondence} Adress to correspondence: Dra. Maria Imaculada Muniz-Junqueira. Departamento de Pediatria Faculdade de Ciências da Saúde Universidade de Brasília. 70910 Brasília, DF, Brasil.

ABSTRACT

T-cell function was evaluated in 29 patients with either hepatointestinal or hepatosplenic schistosomiasis by intradermal tests to recall antigens. Immunodepression was detected in 26% of the subjects with hepatointestinal schistosomiasis and in 50% of those with the hepatosplenic form. Cellular immunodepression was related to worm load and spleen size. This non specific T-cell immunodepression may represent a serious constraint to the elimination of intracellular pathogens both in hepatosplenic or hepatointestinal schistosomiasis.

Keywords: Schistosomiasis. T-cell dependent immunodepression.

RESUMO

A imunidade celular foi avaliada em 29 pacientes com as formas hepatoesplênica ou hepatointestinal, da esquistossomose mansoni, através de testes intradérmicos com antígenos não relacionados ao Schistosoma. Imunodepressão foi detectada em 26% dos pacientes com a forma hepatointestinal e em 50% daqueles com a forma hepatoesplênica. A imunodepressão celular foi relacionada com a carga parasitária e o tamanho do baço. Esta imunodepressão celular pode dificultar a eliminação de patógenos intracelulares tanto na forma hepatoesplênica quanto na forma hepatointestinal da esquistossomose.

Palavras-chave: Esquistossomose. Imunodepressão celular.

Full text available only in PDF format.

Texto completo disponível apenas em PDF.

Recebido para publicação em 16/10/89.

Núcleo de Medicina Tropical e Nutrição e Laboratório de Imunologia Celular, Faculdade de Ciências da Saúde, Universidade de Brasília. Brasília, DF, Brasil.

This work was supported by CNPq (Proc. n^o 40.1041/PIDE VI and 40.1868/87).

1. Andrade ZA, Warren KS. Mild prolonged schistosomiasis in mice: alterations in host response with time and the development of portal fibrosis. Transactions of the Royal Society of Tropical Medicine and Hygiene 58:53- 57, 1964.
2. Attallah AM, Smith AH, Murrell KD, Fleischer T, Woody J, Vannier WE, Scher I, Ahmed A, Sell KW. Characterization of the immunosuppressive state during Schistosoma mansoni infection. Journal of Immunology 122:1413-1420, 1979.
3. Barsoum IS, Gamil FM, Al-Khafif MA, Ramzy RM, El Alamy MA, Colley DG. Immune responses and immunoregulation in relation to human schistosomiasis in Egypt. I. Effect of treatment on in vitro cellular responsiveness. The American Journal of Tropical Medicine and Hygiene 31:1181-1187, 1982.
4. Blanden RV, Machaness GB, Collins FM. Mechanisms of acquired resistance in mouse typhoid. Journal of Experimental Medicine 124:585-600, 1966.
5. Boros DL, Pelley RP, Warren KS. Spontaneous modulation of granulomatous hypersensitivity inschistosomiasis mansoni. Journal of Immunology 114:1437- 1441, 1975.
6. Colley DG, Todd CW, Lewis FA, Goodgame RW. Immune responses during human schistosomiasis mansoni. VI. In vitro nonspecific suppresion of phytohemagglutinin responsiveness induced by exposure to certain schistosomal preparations. Journal of Immunology 122:1447-1453, 1979.
7. Cottrell BJ, Humber D, Sturrock RF, Seitz H, Rees P. Non-specific cell mediated immunity in patients infected with Schistosoma mansoni in Kenya. Transactions of the Royal Society of Tropical Medicine and Hygiene 76:234-237, 1982.
8. Coutinho AD, Antunes MTA, Domingues ALC. Estudo da imunidade humoral e celular na doença hepática esquistossomótica. Revista do Instituto de Medicina Tropical de São Paulo 24:282-291, 1982.
9. Edelson PJ, Intracellular parasites and phagocytic cell: cell biology and pathophysiology. Reviews of Infectious Diseases 4:124-135, 1982.
10. Ellner JJ, Olds GR, Osman GS, El Kholy A, Mahmoud AAF. Dichotomies in the reactivity to worm antigen in human Schistosomiasis mansoni Journal oflmmunology 126:309-312, 1981.
11. Gazzinelli G, Katz N, Rocha RS, Colley DG. Immune responses during human Schistosomiasis mansoni VIII. Differential in vitro cellular responsiveness to adult worm and schistosomular tegumental preparations. The American Journal of Tropical Medicine and Hygiene 32:326-333, 1983.
12. Hahn H, Kaufmann SH. The role of cell-mediated immunity in bacterial infections. Reviews of Infectious Disease 3:1221-1250, 1981.
13. Higashi GI. The interaction of Schistosoma and bacterial infections. WHO. Expert Committee on the Control of Schistosomiasis, Geneva 8-13 november, SCH/EC/WP/84.30, 1984.
14. Katz N, Chaves A, Pellegrino J. A simples device for quantitative stool thick-smear technique in Schistosomiasis mansoni Revista do Instituto de Medicina Tropical de São Paulo 14:397-400, 1972.
15. Kita E, Emoto M, Yasui K, Yasui K, Katsui N, Nishi K, Kashiba S. Cellular aspects of the longer-lasting immunity against mouse typhoid infection afforded by the livecell and ribosomal vaccines. Immunology 57:431-435, 1986.
16. Mota-Santos TA, Gazzinelli G, Ramalho-Pinto FJ, Pellegrino J, Dias de Silva W. Immunodepression in mice following Schistosoma mansoni infection. Revista do Instituto de Medicina Tropical de São Paulo 18:246- 250, 1976.
17. Mota-Santos TA, Tavares CAP,Gazzinelli G, Pellegrino J. Immunosuppression mediated by adult worms in chronic Schistosomiasis mansoni The American Journal of Tropical Medicine and Hygiene 26:727-731, 1977.
18. Nash TE, Cheever AW Ottesen EA, Cook JA. Schistosome infections in humans: perspectives and recent findings. NIH Conference. Annals of Internal Medicine 97:740-754, 1982.
19. NashTE, Ottesen EA, Cheever AW. Antibody response to a polysaccharide antigen present in the schistosome gut. II. Modulation of antibody response. The American Journal of Tropical Medicine and Hygiene 27:944-950, 1978.
20. Olds GR, Kholy AE, Ellner JJ. Two distinctive patterns of monocyte immunoregulatory and effector functions in heavy human infections with Schistosoma mansoni Journal oflmmunology 131:954-958, 1983.
21. Ottesen EA, Poindexter RW. Modulation of the host response in human schistosomiasis. II. Humoral factors which inhibit lymphocyte proliferative response to parasite antigens. The American Journal of Tropical Medicine and Hygiene 29:592-597, 1980.
22. Pelley RP, RuffierJJ, Warren KS. Suppressive effect of a chronic helminth infection, Schistosomiasis mansoni, on the in vitro responses of spleen and lymph node cells to the T cell mitogens phytohemagglutinin and concanavalin A. Infection and Immunity 13:1176-1183, 1976.
23. Prata A. Como caracterizar a forma hepato-esplênica da esquistossomose? In: II Simpósio sobre Esquistossomose p. 179, Salvador, 1970.
24. Reiner NE, Kamel R, Higashi GI, El Naggar A, Aguib M, Ellner JJ, Mahmoud AAF. Concurrent responses of peripheral blood and splenic mononuclear cells to antigenic and motigenic stimulation in human hepatosplenic schistosomiasis. The Journal of Infectious Diseases 140:162-168, 1979.
25. Rocklin RE, Brown AP, Warren KS, Pelley RP, Houba V, Siongok TK, Ouma J, Sturrock RF, Butterworth AE. Factors that modify the cellular-immune response in patients infected by Schistosoma mansoni Journal of Immunology 125:1916-1923, 1980.
26. Rocklin RE, Tracy JW, El Kholy A. Activiation of antigen-specific suppressor cells in human Schistosomiasis mansoni by fractions of soluble egg antigens nonadherent to Con A sepharose. Journal of Immunology 127:2314-2318, 1981.
27. Rosen FS, Wedgwood RJ, Eibl M. Primary immunodeficiency diseases. Clinical Immunology and Immunopathology 40:166-196, 1986.
28. Todd CW, Goodgame RW, Colley DG. Immune response during human Schistosomiasis mansoni VII. Further analysis of the interactions between patient sera and lymphocytes during in vitro blastogenesis to schistosome antigen preparations. The American Journal of Tropical Medicine and Hygiene. 29:875-881, 1980.
29. Warren KS. The secret of the immunopathogenesis of schistosomiasis: in vivo models. Immunological Reviews 61:189-213, 1982.

Adress to correspondence:

Dra. Maria Imaculada Muniz-Junqueira.

Departamento de Pediatria

Faculdade de Ciências da Saúde

Universidade de Brasília.

70910

Brasília, DF, Brasil.

Publication Dates

Publication in this collection
27 May 2013
Date of issue
Mar 1990

History

Accepted
16 Oct 1989
Received
16 Oct 1989

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. Andrade ZA, Warren KS. Mild prolonged schistosomiasis in mice: alterations in host response with time and the development of portal fibrosis. Transactions of the Royal Society of Tropical Medicine and Hygiene 58:53- 57, 1964.

[2] 2. Attallah AM, Smith AH, Murrell KD, Fleischer T, Woody J, Vannier WE, Scher I, Ahmed A, Sell KW. Characterization of the immunosuppressive state during Schistosoma mansoni infection. Journal of Immunology 122:1413-1420, 1979.

[3] 3. Barsoum IS, Gamil FM, Al-Khafif MA, Ramzy RM, El Alamy MA, Colley DG. Immune responses and immunoregulation in relation to human schistosomiasis in Egypt. I. Effect of treatment on in vitro cellular responsiveness. The American Journal of Tropical Medicine and Hygiene 31:1181-1187, 1982.

[4] 4. Blanden RV, Machaness GB, Collins FM. Mechanisms of acquired resistance in mouse typhoid. Journal of Experimental Medicine 124:585-600, 1966.

[5] 5. Boros DL, Pelley RP, Warren KS. Spontaneous modulation of granulomatous hypersensitivity inschistosomiasis mansoni. Journal of Immunology 114:1437- 1441, 1975.

[6] 6. Colley DG, Todd CW, Lewis FA, Goodgame RW. Immune responses during human schistosomiasis mansoni. VI. In vitro nonspecific suppresion of phytohemagglutinin responsiveness induced by exposure to certain schistosomal preparations. Journal of Immunology 122:1447-1453, 1979.

[7] 7. Cottrell BJ, Humber D, Sturrock RF, Seitz H, Rees P. Non-specific cell mediated immunity in patients infected with Schistosoma mansoni in Kenya. Transactions of the Royal Society of Tropical Medicine and Hygiene 76:234-237, 1982.

[8] 8. Coutinho AD, Antunes MTA, Domingues ALC. Estudo da imunidade humoral e celular na doença hepática esquistossomótica. Revista do Instituto de Medicina Tropical de São Paulo 24:282-291, 1982.

[9] 9. Edelson PJ, Intracellular parasites and phagocytic cell: cell biology and pathophysiology. Reviews of Infectious Diseases 4:124-135, 1982.

[10] 10. Ellner JJ, Olds GR, Osman GS, El Kholy A, Mahmoud AAF. Dichotomies in the reactivity to worm antigen in human Schistosomiasis mansoni Journal oflmmunology 126:309-312, 1981.

[11] 11. Gazzinelli G, Katz N, Rocha RS, Colley DG. Immune responses during human Schistosomiasis mansoni VIII. Differential in vitro cellular responsiveness to adult worm and schistosomular tegumental preparations. The American Journal of Tropical Medicine and Hygiene 32:326-333, 1983.

[12] 12. Hahn H, Kaufmann SH. The role of cell-mediated immunity in bacterial infections. Reviews of Infectious Disease 3:1221-1250, 1981.

[13] 13. Higashi GI. The interaction of Schistosoma and bacterial infections. WHO. Expert Committee on the Control of Schistosomiasis, Geneva 8-13 november, SCH/EC/WP/84.30, 1984.

[14] 14. Katz N, Chaves A, Pellegrino J. A simples device for quantitative stool thick-smear technique in Schistosomiasis mansoni Revista do Instituto de Medicina Tropical de São Paulo 14:397-400, 1972.

[15] 15. Kita E, Emoto M, Yasui K, Yasui K, Katsui N, Nishi K, Kashiba S. Cellular aspects of the longer-lasting immunity against mouse typhoid infection afforded by the livecell and ribosomal vaccines. Immunology 57:431-435, 1986.

[16] 16. Mota-Santos TA, Gazzinelli G, Ramalho-Pinto FJ, Pellegrino J, Dias de Silva W. Immunodepression in mice following Schistosoma mansoni infection. Revista do Instituto de Medicina Tropical de São Paulo 18:246- 250, 1976.

[17] 17. Mota-Santos TA, Tavares CAP,Gazzinelli G, Pellegrino J. Immunosuppression mediated by adult worms in chronic Schistosomiasis mansoni The American Journal of Tropical Medicine and Hygiene 26:727-731, 1977.

[18] 18. Nash TE, Cheever AW Ottesen EA, Cook JA. Schistosome infections in humans: perspectives and recent findings. NIH Conference. Annals of Internal Medicine 97:740-754, 1982.

[19] 19. NashTE, Ottesen EA, Cheever AW. Antibody response to a polysaccharide antigen present in the schistosome gut. II. Modulation of antibody response. The American Journal of Tropical Medicine and Hygiene 27:944-950, 1978.

[20] 20. Olds GR, Kholy AE, Ellner JJ. Two distinctive patterns of monocyte immunoregulatory and effector functions in heavy human infections with Schistosoma mansoni Journal oflmmunology 131:954-958, 1983.

[21] 21. Ottesen EA, Poindexter RW. Modulation of the host response in human schistosomiasis. II. Humoral factors which inhibit lymphocyte proliferative response to parasite antigens. The American Journal of Tropical Medicine and Hygiene 29:592-597, 1980.

[22] 22. Pelley RP, RuffierJJ, Warren KS. Suppressive effect of a chronic helminth infection, Schistosomiasis mansoni, on the in vitro responses of spleen and lymph node cells to the T cell mitogens phytohemagglutinin and concanavalin A. Infection and Immunity 13:1176-1183, 1976.

[23] 23. Prata A. Como caracterizar a forma hepato-esplênica da esquistossomose? In: II Simpósio sobre Esquistossomose p. 179, Salvador, 1970.

[24] 24. Reiner NE, Kamel R, Higashi GI, El Naggar A, Aguib M, Ellner JJ, Mahmoud AAF. Concurrent responses of peripheral blood and splenic mononuclear cells to antigenic and motigenic stimulation in human hepatosplenic schistosomiasis. The Journal of Infectious Diseases 140:162-168, 1979.

[25] 25. Rocklin RE, Brown AP, Warren KS, Pelley RP, Houba V, Siongok TK, Ouma J, Sturrock RF, Butterworth AE. Factors that modify the cellular-immune response in patients infected by Schistosoma mansoni Journal of Immunology 125:1916-1923, 1980.

[26] 26. Rocklin RE, Tracy JW, El Kholy A. Activiation of antigen-specific suppressor cells in human Schistosomiasis mansoni by fractions of soluble egg antigens nonadherent to Con A sepharose. Journal of Immunology 127:2314-2318, 1981.

[27] 27. Rosen FS, Wedgwood RJ, Eibl M. Primary immunodeficiency diseases. Clinical Immunology and Immunopathology 40:166-196, 1986.

[28] 28. Todd CW, Goodgame RW, Colley DG. Immune response during human Schistosomiasis mansoni VII. Further analysis of the interactions between patient sera and lymphocytes during in vitro blastogenesis to schistosome antigen preparations. The American Journal of Tropical Medicine and Hygiene. 29:875-881, 1980.

[29] 29. Warren KS. The secret of the immunopathogenesis of schistosomiasis: in vivo models. Immunological Reviews 61:189-213, 1982.