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Revista da Sociedade Brasileira de Medicina Tropical

Print version ISSN 0037-8682

Rev. Soc. Bras. Med. Trop. vol.23 no.2 Uberaba Apr./June 1990

http://dx.doi.org/10.1590/S0037-86821990000200003 

ARTIGOS

 

Bioquímica da esquistossomose mansônica: envolvimento dos siderossomos nos processos inflamatórios hepáticos

 

 

Luiz Erlon Araújo Rodrigues; Pierre Galle

Endereço para correspondência

 

 


RESUMO

Os processos inflamatórios que se desenvolvem durante as etapas avançadas da esquistossomose mansônica hepática foram relacionados, com o acúmulo de siderossomos, a capacidade dos íons ferrosos/férricos de desencadearem a formação de radicais livres e aperoxidação de lipídios membranáceos, assim como à diminuição da estabilidade das membranas dos diversos componentes do compartimento lisossômico hepático. Os lisossomos isolados de figados de camundongos infectados por 100 cercárias, com 80 e 100 dias de infecção, foram respectivamente, 2,5 e quase 4 vezes mais frágeis que os controles, isolados de figados de camundongos não infectados. A presença de siderossomos em grande quantidade foi demonstrada por espectrometria aos raios-X.

Palavras-chave: Esquistossomose mansônica. Metabolismo de ferro. Processo inflamatório. Superóxidos. Radicais livres.


ABSTRACT

The inflammatory processes that develop during the advanced stages of hepatic Schistosomiasis mansoni have been related in this study to: (a) accumulation of siderosomes; (b) capacity of the ferrous/ferric ions to unleash the formation of free radicals; (c) peroxidation of membranaceous lipids and; (d) reduction of stability of the membranes of several components of the hepatic lysosomal compartment. The lysosomes isolated from the livers of infected mice by 100 cercariae, with 80 and 100 days of infection, were respectively 2.5 and almost 4 times weaker than the control ones isolated from livers of non-infected mice. The presence of a great quantity of siderosomes has been demonstrated by transmission electronic microscopy and X-ray spectrometry microanalysis.

Keywords: Schistosomiasis mansoni. Iron metabolism. Inflammatory process. Superoxide. Free radicals.


 

 

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Endereço para correspondência:
Dr. Luiz Erlon Araújo Rodrigues.
Departamento de Biofunção, Setor de Bioquímica/ICS/UFBA.
Caixa Postal 4777
40140
Salvador, BA, Brasil.

 

 

Recebido para publicação em 03/04/90.

 

 

Departamento de Biofunção, Setor de Bioquímica do Instituto de Ciências da Saúde da Universidade Federal da Bahia, Salvador, BA, Brasil.
Laboratoire de Biophysique, Facuité de Médecine, Université de Paris, Val de Marne, Créteil, France.

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