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Revista da Sociedade Brasileira de Medicina Tropical

Print version ISSN 0037-8682

Rev. Soc. Bras. Med. Trop. vol.27 no.3 Uberaba July/Sept. 1994

http://dx.doi.org/10.1590/S0037-86821994000300003 

ARTIGOS

 

Lesões do trato gastrointestinal na síndrome da imunodeficiência adquirida: estudo de 45 necrópsias consecutivas

 

Gastrointestinal tract lesions in the acquired immunodeficiency syndrome: study of forty five consecutive necropsies

 

 

 

Maria Goretti Freire de Carvalho; Maria Aparecida Marchesan Rodrigues; Mariângela Ester Marques; Marcello Franco; Mário Rubens Montenegro

Endereço para correspondência

 

 


RESUMO

Com objetivo de estudar afrequência e etiologia das lesões do tubo digestivo na Síndrome da Imunodeficiência Adquirida (AIDS), foram analisadas retrospectivamente 45 necrópsias consecutivas de pacientes adultos portadores do vírus da AIDS. Lesões macroscópicas e cortes histológicos de amostras da boca à região anal foram estudados, sendo as lâminas coradas por HE, métodos histoquímicos ou imunohistoquímicos. Trinta e sete (82,3 %)pacientes apresentaram lesões no tubo digestivo. O local mais freqüente de lesões foi a boca (73,3%), seguido do cólon (55,5%). Lesões múltiplas foram identificadas em 17 (37,7%) casos. O diagnóstico mais prevalente foi infecção pelo citomegalovírus (35,7%) identificado predominantemente no cólon. Candidíasefoi mais freqüente na boca (26,6%) e infecção herpética no esôfago (8,8%). Verificou-se leucoplasiapilosa oral em 16 (35,5%) eneoplasias emsete (15,5%). Asneoplasias incluíram quatro sarcomas de Kaposi, dois Carcinomas intramucosos anais e um linfoma gástrico. Os dados do presente estudo confirmam a importância do trato gastrointestinal como sede de alterações patológicas relacionadas à AIDS.

Palavras-chave: Síndrome da imunodeficiência adquirida. Infecções oportunistas. Trato gastrointestinal. Necropsia.


ABSTRACT

This study was designed to evaluate restropectivefy the frequency and etiology of the gastrointestinal (GI) lesions in 45 consecutive necropsies of adult patients with Acquired Immunodeficiency Syndrome (AIDS). Gross descriptions and histological sections of the GI tract, from mouth to anus, were reviewed. The slides were H&E stained, and when necessary special stains and immunohistochemicalmethods were also employed. There were lesions in GI tract in 37(82.3%) patients; the mouth was the segment mostfrequently involved (73.3% of the cases), followed by the colon (55.5%). Multiple lesions occurred in 17 (37.7%) cases. Cytomegalovirus caused colonic lesions in 35.7% of the cases. Candidiasis was observed in 26.6% mainly in the mouth and herpes simplex (8.8%) was the important agent of esophageal lesions. Oral hairy leukoplasia associated with HPV was found in 16 (35.5%) cases. Neoplasia was diagnosed in 7 (15.5%) cases: four Kaposi's sarcoma, two anal intramucosal carcinomas and one gastric lymphoma. Our data confirm the high frequency and variety of GI tract alterations in AIDS.

Keywords: Acquired immunodeficiency syndrome. Opportunistic infections. Digestive tract. Necropsy.


 

 

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

 

 

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Endereço para correspondência:
Dra. Maria Aparecida M. Rodrigues.
Depto. de Patologia/FM/UNESP
Distrito de Rubião Junior s/n
18618-000
Botucatu, SP.

 

 

Recebido para publicação em 06/01/94.

 

 

Departamento de Patologia, Faculdade de Medicina da Universidade Estadual Paulista (UNESP) Botucatu, SP.

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