Abstracts
In this study, which was undertaken in relation to the histopathologic behavior of two different strains (LE-Belo Horizonte, MG and SJ - São José dos Campos, SP) in infections and reinfections (homologous or heterologous) with Schistosoma mansoni, the authors confirmed a more accentuated pathogenicity of the SJ strain. All the reinfections showed the presence of typical granulomas of the acute phase, when performed either with the same strain (homologous) or with a different strain (heterologous) of the parasite of the primo infection. The possible mechanisms responsible for reactivation of the immunopathologic response in reinfections are discussed.
Granuloma; Granulomatous reaction; Schistosoma mansoni; Geographical strains
No presente estudo, verificou-se o comportamento histopatológico das infecções e reinfecções, homólogas ou heterólogas, das cepas LE (Belo Horizonte, MG) e SJ (São José dos Campos, SP) de Schistosoma mansoni. Confirmou-se uma maior patogenicidade da cepa SJ de S. mansoni. As reinfecções, independentemente de terem sido feitas com a mesma cepa (homóloga) ou cepa diferente da primo infecção (heteróloga) do parasito, mostraram a presença de granulomas típicos da fase aguda. São discutidos os possíveis mecanismos responsáveis pela reagudização da resposta imunopatológica nas reinfecções.
Granuloma; Reação granulomatosa; Schistosoma mansoni; Cepas geográficas
ARTICLES
Aspects of the granulomatous reaction in the liver of mice infected and reinfected with two different geographical strains of Schistosoma mansoni
Pedro Raso; Paulo Marcos Z. Coelho; Nivaldo H. Toppa; Rômulo T. Mello
Adress to correspondence Adress to correspondence: Prof. Paulo Marcos Z. Coelho. GIDE/ICB/UFMG, Caixa Postal 486, 30161-970 Belo Horizonte, MG, Brasil.
ABSTRACT
In this study, which was undertaken in relation to the histopathologic behavior of two different strains (LE-Belo Horizonte, MG and SJ - São José dos Campos, SP) in infections and reinfections (homologous or heterologous) with Schistosoma mansoni, the authors confirmed a more accentuated pathogenicity of the SJ strain. All the reinfections showed the presence of typical granulomas of the acute phase, when performed either with the same strain (homologous) or with a different strain (heterologous) of the parasite of the primo infection. The possible mechanisms responsible for reactivation of the immunopathologic response in reinfections are discussed.
Keywords: Granuloma. Granulomatous reaction. Schistosoma mansoni. Geographical strains.
RESUMO
No presente estudo, verificou-se o comportamento histopatológico das infecções e reinfecções, homólogas ou heterólogas, das cepas LE (Belo Horizonte, MG) e SJ (São José dos Campos, SP) de Schistosoma mansoni. Confirmou-se uma maior patogenicidade da cepa SJ de S. mansoni. As reinfecções, independentemente de terem sido feitas com a mesma cepa (homóloga) ou cepa diferente da primo infecção (heteróloga) do parasito, mostraram a presença de granulomas típicos da fase aguda. São discutidos os possíveis mecanismos responsáveis pela reagudização da resposta imunopatológica nas reinfecções.
Palavras-chave: Granuloma. Reação granulomatosa. Schistosoma mansoni. Cepas geográficas.
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Recebido para publicação em 30/03/94.
Universidade Federal de Ouro Preto, Ouro Preto, MG e Departamentos de Parasitologia do Instituto de Ciências Biológicas, de Anatomia Patológica da Faculdade de Medicina e de Análises Clínicas e Toxicológicas da Faculdade de Farmácia, Universidade Federal de Minas Gerais, MG, Brasil.
Financial support from CNPq, FAPEMIG, FINEP, PRPq, Brazil and WHO, Switzerland.
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Publication Dates
-
Publication in this collection
10 Apr 2013 -
Date of issue
Dec 1994
History
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Accepted
30 Mar 1994 -
Received
30 Mar 1994