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Revista da Sociedade Brasileira de Medicina Tropical

Print version ISSN 0037-8682

Rev. Soc. Bras. Med. Trop. vol.27 no.4 Uberaba Oct./Dec. 1994

http://dx.doi.org/10.1590/S0037-86821994000400004 

ARTICLES

 

Aspects of the granulomatous reaction in the liver of mice infected and reinfected with two different geographical strains of Schistosoma mansoni

 

 

Pedro Raso; Paulo Marcos Z. Coelho; Nivaldo H. Toppa; Rômulo T. Mello

Adress to correspondence

 

 


ABSTRACT

In this study, which was undertaken in relation to the histopathologic behavior of two different strains (LE-Belo Horizonte, MG and SJ - São José dos Campos, SP) in infections and reinfections (homologous or heterologous) with Schistosoma mansoni, the authors confirmed a more accentuated pathogenicity of the SJ strain. All the reinfections showed the presence of typical granulomas of the acute phase, when performed either with the same strain (homologous) or with a different strain (heterologous) of the parasite of the primo infection. The possible mechanisms responsible for reactivation of the immunopathologic response in reinfections are discussed.

Keywords: Granuloma. Granulomatous reaction. Schistosoma mansoni. Geographical strains.


RESUMO

No presente estudo, verificou-se o comportamento histopatológico das infecções e reinfecções, homólogas ou heterólogas, das cepas LE (Belo Horizonte, MG) e SJ (São José dos Campos, SP) de Schistosoma mansoni. Confirmou-se uma maior patogenicidade da cepa SJ de S. mansoni. As reinfecções, independentemente de terem sido feitas com a mesma cepa (homóloga) ou cepa diferente da primo infecção (heteróloga) do parasito, mostraram a presença de granulomas típicos da fase aguda. São discutidos os possíveis mecanismos responsáveis pela reagudização da resposta imunopatológica nas reinfecções.

Palavras-chave: Granuloma. Reação granulomatosa. Schistosoma mansoni. Cepas geográficas.


 

 

Full text available only in PDF format.

Texto completo disponível apenas em PDF.

 

 

REFERENCES

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Adress to correspondence:
Prof. Paulo Marcos Z. Coelho.
GIDE/ICB/UFMG,
Caixa Postal 486,
30161-970
Belo Horizonte, MG, Brasil.

 

 

Recebido para publicação em 30/03/94.

 

 

Universidade Federal de Ouro Preto, Ouro Preto, MG e Departamentos de Parasitologia do Instituto de Ciências Biológicas, de Anatomia Patológica da Faculdade de Medicina e de Análises Clínicas e Toxicológicas da Faculdade de Farmácia, Universidade Federal de Minas Gerais, MG, Brasil.
Financial support from CNPq, FAPEMIG, FINEP, PRPq, Brazil and WHO, Switzerland.

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