Dear Editor,
We read with great interest the comments made by Drs. Nawfal R. Hussein and Rawand Al-Qadi regarding our results presented in the article entitled “cagE as a biomarker of the pathogenicity of Helicobacter pylori.” We agree that H. pylori infection should be viewed as multifaceted process, where the environment, host, and microorganism play specific roles in determining asymptomatic infection, colonization, or gastric disease.
In the above-mentioned study, we showed that cagE, a member of the cag pathogenicity island, is one more biomarker that should be considered to best understand the relationship between the microorganism and the host.
Although others authors11. Chomvarin C, Namwat W, Chaicumpar K, Mairiang P, Sangchan A, Sripa B, et al. Prevalence of Helicobacter pylori vacA, cagA, cagE, iceA and babA2 genotypes in Thai dyspeptic patients. Int J Infect Dis 2008 12:30-36.–33. Quiroga AJ, Cittelly DM, Bravo MM. BabA2, oipA and cagE Helicobacter pylori genotypes in Colombian patients with gastroduodenal diseases. Biomedica 2005; 25:325-334. had found similar results, we think that geographic factors (environment and host) have important roles in determining what biomarkers are more significant in each location.
REFERENCES
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1Chomvarin C, Namwat W, Chaicumpar K, Mairiang P, Sangchan A, Sripa B, et al. Prevalence of Helicobacter pylori vacA, cagA, cagE, iceA and babA2 genotypes in Thai dyspeptic patients. Int J Infect Dis 2008 12:30-36.
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2Podzorski RP, Podzorski DS, Wuerth A, Tolia V. Analysis of the vacA, cagA, cagE, iceA, and babA2 genes in Helicobacter pylori from sixty-one pediatric patients from the Midwestern United States. Diagn Microbiol Infect Dis 2003; 46:83-88.
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3Quiroga AJ, Cittelly DM, Bravo MM. BabA2, oipA and cagE Helicobacter pylori genotypes in Colombian patients with gastroduodenal diseases. Biomedica 2005; 25:325-334.
Publication Dates
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Publication in this collection
May-Jun 2014
History
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Received
16 Dec 2013 -
Accepted
22 Jan 2014
