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Revista da Sociedade Brasileira de Medicina Tropical

Print version ISSN 0037-8682On-line version ISSN 1678-9849

Rev. Soc. Bras. Med. Trop. vol.49 no.5 Uberaba Sept./Oct. 2016 

Images in Infectious Diseases

Enlarged hilar lymph node due to Histoplasma

Terezinha do Menino Jesus Silva Leitão1  2 

Iago Farias Jorge1 

Angela Elizabeth de Holanda Araújo Freitas3 

1Departamento de Doenças Infecciosas, Universidade Federal do Ceará, Fortaleza, Ceará, Brazil.

2Hospital São José de Doenças Infecciosas, Fortaleza, Ceará, Brazil.

3Hospital Infantil Albert Sabin, Fortaleza, Ceará, Brazil.

A 13-year-old boy from Northeastern Brazil presented with a 12-month history of productive cough. Physical examination revealed small cervical and epitrochlear lymph nodes. He denied contact with bats, but stated that pigeons were located near his school. Red blood cell, leukocyte, and C-reactive protein levels were normal. Chest radiography showed a radiopaque nodule on the left inferior lobe (Figure 1; white arrow) and an amorphous image of a lobulated lineament on the left inferior hilum (5.5×3.5cm), suggesting an adenomegaly. Computed tomography (Figure 2) revealed a 5.6×3.1×3.2-cm lymph node at the left hilum with a necrotic center, peripheral calcification, and splenic granulomas. Bronchoalveolar lavage disclosed a small amount of leukocytes with negative stain and culture results. The tuberculin test and Cytomegalovirus [immunoglobulin M/immunoglobulin G (IgM/IgG)] and Toxoplasma serologies were negative. The Histoplasma serology (immunodiffusion) was positive. Following initiation of itraconazole (400mg/day), the cough remarkably diminished. Disseminated histoplasmosis is frequently diagnosed in patients with acquired immunodeficiency syndrome (AIDS) in Brazil. However, the acute pulmonary form is rarely diagnosed due to its self-limiting nature and unawareness of local physicians regarding its manifestations and complications, including mediastinal or hilar lymphadenitis1. The diagnosis of acute pulmonary histoplasmosis in patients with no history of intense exposure to this fungus is difficult. Tuberculosis and malignancies are frequently the main hypotheses2) (3. The elapsed time from symptom onset until seeking medical assistance may suggest an infectious agent. The positive serology for Histoplasma combined with the remarkable response to itraconazole may corroborate the presumptive diagnosis of this mycosis.


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2. Aide MA. Chapter 4: histoplasmosis. J Bras Pneumol () 2009; 35:1145-1151. [ Links ]

3. Deus Filho A, Wanke B, Cavalcanti MAS, Martins LMS, Deus ACB. Histoplasmose no Nordeste do Brasil: Relato de três casos. Rev Port Pneumol () 2009; 15:109-114. [ Links ]

Received: January 27, 2016; Accepted: April 26, 2016

Corresponding author: Dra. Terezinha do Menino Jesus Silva Leitão. e-mail:

The authors declare that there is no conflict of interest.

Creative Commons License This is an open-access article distributed under the terms of the Creative Commons Attribution License