SciELO - Scientific Electronic Library Online

vol.52Simultaneous occurrence of Kaposi sarcoma and tuberculosis; Kaposi sarcoma and lymphoma in the same lymph node: a report on two HIV-positive patients from ZimbabweTherapeutic failure after regimen with artemether-lumefantrine combination therapy: a report of three cases in Benin City, Nigeria índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados




Links relacionados


Revista da Sociedade Brasileira de Medicina Tropical

versão impressa ISSN 0037-8682versão On-line ISSN 1678-9849

Rev. Soc. Bras. Med. Trop. vol.52  Uberaba  2019  Epub 10-Out-2019 

Case Report

Secondary syphilis with pulmonary involvement mimicking lymphoma: a case report

Kelwya Bruna Vasconcelos Florencio1 

Anderson Dias da Costa1 

Thaís Cabral de Melo Viana1 

Daniel Christiano de Albuquerque Gomes1 

Pedro Alves da Cruz Gouveia1

1Universidade Federal de Pernambuco, Hospital das Clínicas, Serviço de Clínica Médica, Recife, PE, Brasil.


We present a case of atypical presentation of secondary syphilis with extensive lymph node involvement and pulmonary lesions, initially suspected as lymphoma. The patient presented with weight loss, dry cough, chest pain, palpable lymph nodes in several peripheral chains, and multiple pulmonary nodules and masses on chest imaging. The key features for secondary syphilis diagnosis were a lymph node biopsy suggestive of reactive lymphadenopathy, positive serologic tests for syphilis, and complete recovery after antisyphilitic treatment.

Keywords: Syphilis; Pulmonary lesions; Lymphoma


Syphilis is an infection caused by the spirochete Treponema pallidum. It is endemic in developing and underdeveloped countries. Most new cases are sexually acquired. Syphilis carriers may present with a wide range of symptoms depending on the disease stage, while some may only present with serological evidence of Treponema1. Secondary syphilis may present as a cutaneous lesion or, less commonly, mucosal lesions, diffuse lymphadenopathy, hepatosplenomegaly, liver disease, or nephrotic syndrome. Pulmonary involvement is rare in patients with secondary syphilis2. Diagnosing syphilis may prove challenging because of the diverse clinical presentations and cases mimicking other pathologies because of which it has been labelled "the great mimicker"3. Herein, we present a case of syphilis with diffuse and pulmonary nodal involvement, which was initially evaluated as probable lymphoma.


A 26-year-old man, with no comorbidities, sought medical care for fever, dry cough, and pleuritic chest pain for several weeks. He also reported unintentional weight loss of about 10 kg (approximately 15% of his total weight) over the past year, hyporexia, and sporadic night fever and sweats. Physical examination revealed palpable lymph nodes of elastic, painless, mobile consistency in the supraclavicular, epitrochlear, and bilateral inguinal regions, and a larger node in the left axilla, measuring around 3 cm. He reported no odynophagia or flu-like symptoms. There were no abnormalities in the complete blood count, liver enzymes, electrolytes, renal function, canalicular enzymes, or lactic dehydrogenase.

Computed tomography (CT) performed to evaluate the lymphadenopathy demonstrated a left pulmonary hilar mass, involving the pulmonary artery-vein segments, without reducing the calibers, and the bronchopulmonary segments. These findings were suggestive of a lymphoproliferative process. A similar mass was observed adjacent to the large right fissure in the lateral segment of the middle lobe (Figures 1A, 1B, 1C). Multiple pulmonary nodules and solid micronodules were present with a predominantly peripheral perivascular distribution, affecting all lobes, and associated with multifocal inter- and intralobular septal thickening. The findings suggested lymphatic and hematogenic dissemination of the primary process. Multiple left axillary, bilateral supraclavicular, prevascular, paratracheal, subcarinal, and hilar lymph nodes were swollen.

FIGURE 1: A, B, C: Pre-treatment chest computed tomography (CT) images showing pulmonary masses in the left hilum and adjacent to the right fissure and multiple pulmonary nodules secondary to pulmonary involvement in secondary syphilis. D, E, F: Chest CT images after treatment for syphilis with near total regression of previous lesions. 

Suspecting a probable lymphoma, an excisional biopsy of the left axillary lymph node was performed. Histopathological and immunohistochemical studies were consistent with reactive lymphadenopathy, with centrofollicular hyperplasia and foci of progressively transformed germinal centers, and without evidence of neoplasia (Figure 2).

FIGURE 2: Histopathological findings of excisional lymph node biopsy, with expanded and "activated" lymphoid follicles and prominent germinative centers, consistent with reactive lymphadenopathy (hematoxylin and eosin; original magnification ×100). 

After excluding lymphoid malignancy, detailed tests were performed for the possibility of infectious disease-causing lymphadenopathy. Serologic tests were negative for human immunodeficiency virus (HIV), viral hepatitis, cytomegalovirus, and toxoplasmosis. The venereal disease research laboratory (VDRL) test was positive with a 1:64 titer. Syphilis was confirmed by a positive treponemal test. The patient presented with no chancre on the penis or typical skin changes and reported no previous lesions or treatment for syphilis. A treatment regimen was initiated for late latent syphilis with three weekly doses of intramuscular benzathine penicillin.

At the 2-month outpatient follow-up after discharge, total regression of palpable lymphadenopathy was observed at all foci of prior nodal involvement. The patient reported improvement in cough, night sweats, and weight loss and showed a negative VDRL test, with a 1:1 titer. Chest CT with controlled contrast demonstrated significant regression of lesions, with no hilar mass or mediastinal lymph node enlargement (Figures 1D, 1E, 1F). A regular-contour nodule was located in the lateral segment of the middle lobe, measuring 0.9 cm, where a 3-cm mass had been observed in the initial image.


According to the World Health Organization, approximately 17.7 million individuals aged 15-49 years worldwide presented with syphilis in 2012, followed by 5.6 million new cases every year. The prevalence and incidence of syphilis vary substantially with region and country. The highest prevalence is in Africa, and over 60% of new cases occur in low- and middle-income countries1. The prevalence of syphilis in HIV-infected patients has shown an increasing trend. HIV coinfection may alter the presentation of secondary syphilis by suppressing the immune system and commonly present atypically1,4. Despite atypical presentation, our patient did not show coinfection.

Although pulmonary involvement in cases of tertiary and congenital syphilis have been described, they have been rare in secondary syphilis2,5. Pulmonary lesions in secondary syphilis were first described in 1968 and may present as interstitial infiltrates, lung consolidation with or without pleural effusion and a solitary pulmonary nodule or multiple pulmonary nodules (most common finding) with or without cavitation2,5. Patients may be asymptomatic or present with respiratory symptoms, such as dry or productive cough and chest pain (most frequent symptom)2. As it is clinically non-specific, detection of pulmonary involvement with syphilis may be missed if chest imaging is not performed. Our patient presented with dry cough and chest pain and demonstrated multiple pulmonary nodules and masses on CT.

The differential diagnosis for pulmonary involvement in patients with syphilis is extensive and includes primary and metastatic lung cancer, lymphoma, fungal infection, tuberculosis, septic embolism, pulmonary infarction, sarcoidosis, rheumatoid nodules, and vasculitis2,6. While microbiological diagnosis of syphilis in these cases is difficult, transbronchial biopsy, open lung biopsy, bronchial lavage, immunohistochemistry, and polymerase chain reaction may reveal the presence of Treponema pallidum7.

Proposed by Coleman et al. in 1983, clinical criteria for diagnosing pulmonary involvement in secondary syphilis are: (1) presence of history and clinical findings consistent with secondary syphilis; (2) pulmonary abnormalities on X-ray with or without pulmonary symptoms or signs; (3) positive serological tests for syphilis; (4) exclusion of other pulmonary diseases, when possible, using bacilloscopy, serological tests, cultures, and cytological examination of sputum; and (5) therapeutic response to treatment8. Clinical and radiological responses to penicillin confirm pulmonary syphilis and may help exclude differential diagnoses7,9. Reportedly, lung lesions respond well to treatment, and imaging findings are resolved in weeks or around six months2. In the present case, although the patient had no history or typical findings of secondary syphilis, the positive response to therapy within two months and partial resolution of a reactive lymph node led to the diagnosis.

Lymphadenopathy is a frequent clinical finding, with a wide differential diagnosis, including infectious diseases, malignant lymphoproliferative disorders, metastases, and autoimmune diseases10,11. Lymph node involvement is classic in secondary syphilis, including the cervical, inguinal, and epitrochlear lymph nodes, although even they may show atypical features10-12. Our patient presented with lymphadenopathy with some suggestive signs of malignancy, such as presence of systemic symptoms, lymph nodes larger than 2 cm, and supraclavicular and mediastinal lymph node involvement. Lymphoma was suspected because of lymph node involvement and lung lesions, and an excisional axillary lymph node biopsy was performed. Cases of secondary syphilis presenting with extensive lymph node disease mimicking a lymphoma have been reported2,5,10,12(Table 1). The five reported patients were men, and only one exhibited typical symptoms of syphilis, such as rashes on the hands and feet2. Almost all cases presented with systemic symptoms, and two cases presented with pulmonary involvement2,5.

TABLE 1: Summary of clinical reports of syphilis mimicking a lymphoma. 

Author Age/Sex Typical symptoms Lymph nodes involved Lung involvement Systemic Symptoms
Park (2013) 45/Male No Gastrohepatic ligament, perigastric, No Weakness, hair loss, anorexia,
aortocaval, splenic hilar, mesenteric, and weight loss, and night sweats
bilateral inguinal, cervical, and supraclavicular
Cerchione (2017) 56/Male No Latero-cervical, supraclavicular, No Fever, night sweats, and weight
submandibular, and bilateral axillary loss
Komeno (2018) 27/Male No Bilateral cervical and periportal Yes Fever, night sweats, and loss of
Ohta (2018) 39/Male Rashes on Bilateral cervical, left mediastinal, and Yes None
hands and feet bilateral axillary
Present study 26/Male No Supraclavicular, epitrochlear, bilateral Yes Fever, dry cough, respiratory
inguinal, left axillary, bilateral supraclavicular, chest pain, weight loss,
paratracheal, subcarinal, and pulmonary hilar hyporexia, and night sweats

Histopathological analysis of lymph nodes affected by syphilis demonstrates a non-specific response pattern of reactive lymphadenopathy, as in our case, or non-caseous granulomatous lymphadenitis, hypertrophy, or capsular fibrosis11,12. In our cases, the histopathological and serological findings and resolution of lesions after treatment for syphilis were considered as diagnostic evidence of secondary syphilis.

Physicians should consider the possibility of syphilis in various clinical situations. This report reinforces the importance of high suspicion and a low threshold for diagnosing syphilis in patients with lymphadenopathy and unexplained pulmonary lesions, even in the absence of typical cutaneous and genital lesions. Despite reports of syphilis mimicking neoplastic diseases, especially lymphoma, this diagnosis is often neglected. Herein, we reported an unusual case of generalized lymphadenopathy and pulmonary lesions as an atypical presentation of secondary syphilis, which is rarely described in literature.


The authors would like to thank the patient for his permission to present this report and to the medical team and other health professionals for providing patient care. The authors also thank the medical colleagues Afrânio and Aldênison for their help with CT and pathological images.


1. Peeling RW, Mabey D, Kamb ML, Chen XS, Radolf JD, Benzaken AS. Syphilis. Nat Rev Dis Primers. 2017;3:17073. [ Links ]

2. Ohta A, Furusyo N, Kishihara Y, Eiraku K, Murata M, Kainuma M, et al. Secondary Syphilis with Pulmonary Involvement. Intern Med. 2018;57(1):121-6. [ Links ]

3. Bissessor M, Chen M. Syphilis, the great mimicker, is back. Aust Fam Physician. 2009;38(6):384-7. [ Links ]

4. Signorini DJ, Monteiro MC, de Sá CA, Sion FS, Leitão Neto HG, Lima DP, et al. Prevalence of HIV-syphilis coinfection in a university hospital in the city of Rio de Janeiro in 2005. Rev Soc Bras Med Trop. 2007;40(3):282-5. [ Links ]

5. Komeno Y, Ota Y, Koibuchi T, Imai Y, Iihara K, Ryu T. Secondary Syphilis with Tonsillar and Cervical Lymphadenopathy and a Pulmonary Lesion Mimicking Malignant Lymphoma. Am J Case Rep. 2018;19:238-43. [ Links ]

6. Kim SJ, Lee J, Lee E, Kim I, Joo Park H, Shin C, et al. A case of secondary syphilis presenting as multiple pulmonary nodules. Korean J Intern Med . 2013; 28(2):231-5. [ Links ]

7. Kim H, Seon H, Shin H, Choi Y. Case report: Pulmonary syphilis mimicking pulmonary hematogenous metastases on chest CT and integrated PET/CT. Indian J Radiol Imaging. 2011;21(1):34-7. [ Links ]

8. Coleman DL, McPhee SJ, Ross TF, Naughton JL. Secondary syphilis with pulmonary involvement. West J Med. 1983;138(6):875-8. [ Links ]

9. McCready J, Skrastins R, Downey J, Powis J. Necrotic pulmonary nodules in secondary syphilis. CMAJ. 2011;183(3):E163-E166. [ Links ]

10. Park S, Kang J, Roh J, Huh H, Yeo J, Yeun Kim D. Secondary Syphilis Presenting as a Generalized Lymphadenopathy: Clinical Mimicry of Malignant Lymphoma. Sex Transm Dis. 2013;40(6):490-2. [ Links ]

11. Crevel R, Grefte J, Doorninck D, Sturm P. Syphilis presenting as isolated cervical lymphadenopathy: Two related cases. Journal of Infection. 2000;58:76-8. [ Links ]

12. Cerchione C, Maraolo A, Marano L, Pugliese N, Nappi D, Tosone G, et al. Secondary syphilis mimicking malignancy: A case report and review of literature. J Infect Chemother. 2017;23(8):576-8. [ Links ]

Recebido: 25 de Janeiro de 2019; Aceito: 08 de Maio de 2019

Corresponding author: Dr. Pedro Alves da Cruz Gouveia.

Conflict of Interest: The authors declare that there is no conflict of interest.

Creative Commons License This is an open-access article distributed under the terms of the Creative Commons Attribution License