SciELO - Scientific Electronic Library Online

 
vol.6 issue4Cytogenetically distinguishable sympatric and allopatric populations of the mosquito Anopheles albitarsisIsolamento de Microsporum amazonicum do solo do Estado do Amazonas, Brasil author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

Share


Acta Amazonica

Print version ISSN 0044-5967On-line version ISSN 1809-4392

Acta Amaz. vol.6 no.4 Manaus Dec. 1976

http://dx.doi.org/10.1590/1809-43921976064483 

PATOLOGIA TROPICAL

Evaluation of the Anti Chagas "PF" Vaccine Against two Strains of Leishmania sp. in Hamsters (*)

Jorge R. Arias** 

Humberto Menezes*** 

Rui A. de Freitas** 

**— Department of Medical Sciences. Instituto Nacional de Pesquisas da Amazônia, Manaus.

***— Department of Genetics, School of Medicine, Ribeirão Preto, SP.

Abstract

Amastigotes of two strains of Leishmania sp. were innoculated into golden hamsters (Mesocricetus auratus) 8 and 15 days after innoculation with the anti-chagas "PF" vaccine. There was no significant difference in reduction of infection between the "PF" treated and the control (untreated) hamsters after innoculations with either strain of Leishmania sp.

Sumário

A vacina antichagásica "PF" foi testada em hamsters contra duas cepas de Leishmania. Os animais vacinados com a cepa PF foram desafiadas 8 e 15 dias mais tarde com estas duas cepas de Leishmania. Após o término da experiência, i. e. 150 dias após inoculação, notou-se que a vacina "PF" não tinha efeito protetor contra Leishmania, em hamsters. Os leves aumentos do tempo de latência nos animais vacinados, sugerem que possivelmente uma vacina seja a arma para controlar a alta incidência desta doença na Amazônia Central.

Texto disponível apenas em PDF

*— This project was partly supported by the CNPq Grant SIP/08-131.

Creative Commons License  This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.