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Memórias do Instituto Oswaldo Cruz

Print version ISSN 0074-0276On-line version ISSN 1678-8060

Mem. Inst. Oswaldo Cruz vol.70 no.3 Rio de Janeiro  1972

http://dx.doi.org/10.1590/S0074-02761972000300002 

Estudo dos elementos celulares na medula humana dos adultos I. linhagem plasmocitária

M. R. Q de Kastner1 

Brasil. Ministério da Saúde, Biologia, Brasil

RESUMO

Examinando o conjunto dos resultados obtidos nesta pesquisa e os dados pela literatura, observamos que o aumento numérico de células plasmáticas na medula óssea é um fenômeno relativamente freqüente. Todo hematologista habituado pode facilmente fazer o diagnóstico do estado da célula plasmocitária pela sua morfologia, seu tamanho e sua coloração. Nos quadros mais proeminentes de predominância de células de linhagem plasmocitária, os exames hematológicos e clínicos aliados ao mielograma, auxiliarão no diagnóstico do plasmocitoma. A nosso ver, os sinais (qualitativos), distintivos, de natureza citológica, que aparecem nos mielogramas no caso de plasmocitoma são: a) Pleomorfismo e dismorfismo na célula plasmática; b) "Rouleaux" de hemácias, já visível no hemograma; c) Aumento das dimensões de alguns metamielócitos e bastonetes, acompanhados geralmente de atipias nucleares. Atipias e plurissegmentação nos segmentados; d) No setor plaquetogenético aparecem plaquetas grandes e certo grau de perturbação nos megacarióticos, traduzido ás vezes pela presença de núcleos nus.

ABSTRACT

Two hundred fifty bone marrow specimens, including twenty seven from hematologically normal patients, were examined hitologically. The Wright's and Brachet's stains were used. Plasma cells were rarely seen in the peripheral blood and bone marrow of normal individuals, but they were prominent constituents in some pathological states. A number significantly increased of plasma cells or mieloma cells were usually recognized in bone marrow from patients with plasmacytoma. These cells ranged from a very anaplastic immature form to closely resembling plasma cell. Even in the same patient, considerable pleomorphism often occured, and variation in cell size, number of nuclei and degree of nuclear immaturity were common. Although the results report certain observations regarding to the other cell series in patients with plasmacytoma. The most suggestive evidences were: 1. The red cells exhibited a tendency to agglutinate readily with "rouleaux" formation. 2. Increase in the number of metamyelocytes and segmented neutrophils with great variation in size and nuclear configuration. 3. Great increase in large platelet, atypical megakaryocyte forms and single, multiple or segmented naked nuclei. Details will be described elsewhere.

 

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