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Memórias do Instituto Oswaldo Cruz

Print version ISSN 0074-0276On-line version ISSN 1678-8060

Mem. Inst. Oswaldo Cruz vol.82  suppl.2 Rio de Janeiro  1987 

Methionine enkephalin: immunomodulator in normal volunteers, cancer and AIDS patients

Nicholas P. Plotnikoff1 

Gerald C. Miller2 

Nadim F. Nimeh3 

Joseph Wybran4 

University of Illinois, College of Medicine, Chicago, USA

Immuno-Diagnostics Laboratory Inc, Tulsa, USA

Cleo Craig Memorial Cancer & Research Foundation, Lawton, USA

Universite Libre de Bruxelles, Hospital Erasme, Department of Immunology and Hematology, Brussels, Belgium


Clinical studies of the immunological effects of methionine enkephalin in normal volunteers, cancer, and AIDS patients are summarized. The major immunology changes seen were increases in T cell subsets, natural killer activity, as well as mitogen blastogenesis. Clinically, the cancer and ARC patients did not develop infections.


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