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Memórias do Instituto Oswaldo Cruz

Print version ISSN 0074-0276On-line version ISSN 1678-8060

Mem. Inst. Oswaldo Cruz vol.82  suppl.4 Rio de Janeiro  1987

http://dx.doi.org/10.1590/S0074-02761987000800016 

Human antibody responses to Schistosoma mansoni: does antigen directed, isotype restriction result in the production of blocking antibodies?

David W. Dunne1 

Anthony J. C. Fulford1 

Anthony E. Butterworth1 

David Koech2 

John H. Ouma3 

University of Cambridge, Department of Pathology, Cambridge, UK

Kenya Medical Research Institute, Biomedical Sciences Research Centre, Nairobi, Kenya

Ministry of Health, Division of Vector Borne Diseases, Nairobi, Kenya

ABSTRACT

After treatment young Kenyan schoolchildren are highly susceptible to reinfection with Schistosoma mansoni. Older children and adults are resistant to reinfection. There is no evidence that this age related resistance is due to a slow development of protective immunological mechanisms, rather, it appears that young children are susceptible because of the presence of blocking antibodies which decline with age, thus allowing the expression of protective responses. Correlations between antibody responses to different stages of the parasite life-cycle suggest that, in young children, antigen directed, isotype restriction of the response against cross-reactive polysaccharide egg antigens results in an ineffectual, or even blocking antibody response to the schistosomulum.

 

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