Abstract
Anti-idiotypic (anti-Id) T cells from schistosomiasis patients or former patients proliferate upon exposure to polyclonal or monoclonal anti-soluble egg antigen (SEA) antibodies. Chloroquine does not inhibit, the response, which is induced by F(ab')2 (but not soluble Fab) fragments of these antibodies. Purified T cells from former patients require macrophages or exogenous IL-1 to respond to anti-SEA Ids and can respond to matrix-bound Fab fragments in the presence of IL-1. These anti-Id T cells recognize the Ids directly. Chronic schistosomiasis patients immunoregulate the production of a non-IL-2 lymphokine that stimulates IL-2 receptor expression on resting T cells. This regulation is reversed upon chemotherapeutic cure.
Immunoregulation in human Schistosomiasis by idiotypic interactions and lymphokine-mediated mechanisms
D. G. Colley1
J. C. Parra2
M. A. Montesano3
M. Lima2
E. Nascimento2
B. L. Doughty4
A. Goes2
G. Gazzinelli2
Vanderbilt Univ, VA Medical Center, Nashville, USA
Centro de Pesquisas René Rachou, Belo Horizonte, Brasil
Univ Fed Juiz de Fora, Juiz de Fora, Brasil
Texas A & M Univ, USA
Anti-idiotypic (anti-Id) T cells from schistosomiasis patients or former patients proliferate upon exposure to polyclonal or monoclonal anti-soluble egg antigen (SEA) antibodies. Chloroquine does not inhibit, the response, which is induced by F(ab')2 (but not soluble Fab) fragments of these antibodies. Purified T cells from former patients require macrophages or exogenous IL-1 to respond to anti-SEA Ids and can respond to matrix-bound Fab fragments in the presence of IL-1. These anti-Id T cells recognize the Ids directly. Chronic schistosomiasis patients immunoregulate the production of a non-IL-2 lymphokine that stimulates IL-2 receptor expression on resting T cells. This regulation is reversed upon chemotherapeutic cure.
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Publication Dates
-
Publication in this collection
26 June 2009 -
Date of issue
1987