versão impressa ISSN 0074-0276
Mem. Inst. Oswaldo Cruz v.82 supl.4 Rio de Janeiro 1987
Induced tolerance to Schistosoma mansoni antigens modulates periovular granuloma
FIOCRUZ/UFBa, Centro de Pesquisas Gonçalo Moniz, Brasil
Harvard Medical School, USA
Immunological tolerance to Schistosoma mansoni antigens induced by oral exposure of neonatal and adult mice to adult worm, soluble egg and polysaccharide antigens conducted to modulated periovular granuloma of infected mice. However the tolerance do not interfere in the infection. The estimative population and subpopulation of lymphocytes in the spleen of tolerized (not infected) animals do not differ from normal animals but Lyt 2.2 reactive lymphocytes to Schistosoma antigens was demonstrated in the tolerized animals.