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Memórias do Instituto Oswaldo Cruz

On-line version ISSN 1678-8060

Mem. Inst. Oswaldo Cruz vol.83 no.2 Rio de Janeiro Apr./June. 1988

http://dx.doi.org/10.1590/S0074-02761988000200001 

Experimental canine mucocutaneous leishmaniasis (Leishmania braziliensis braziliensis)

Claude Pirmez1  , Mauro C. A. Marzochi2  , Sergio G. Coutinho3 

Instituto Oswaldo Cruz, Departamento de Imunologia, Rio de Janeiro, Brasil

FIOCRUZ, Escola Nacional de Saúde Pública, Rio de Janeiro, Brasil

FIOCRUZ, Departamento de Protozoologia, Rio de Janeiro, Brasil

ABSTRACT

Four mongrel dogs were intradermically inoculated with 3 x 10**6 Leishmania braziliensis braziliensis promastigotes. Three out of the four animals developed cutaneous lesions respectively 4, 7, and 8 months after. The fourth dog did not develop lesion at the inoculation site, but a mucosal ulcer was seen 16 months after the inoculum. Clinical, histopathological, and serological findings were similar to what is found in natural canine infection as well as in the human disease. These results suggest that dogs may be an useful model for L. b. braziliensis infection.

Key words: Leishmania braziliensis braziliensis; canine experimental infection

RESUMO

Quatro cães foram inoculados por via intredérmica com 3 x 10**6 promastigotos de Leishmania brasiliensis braziliensis. Três deles desenvolveram lesões no sítio do inóculo, mas uma úlcera mucosa foi detectada 16 meses após o inóculo. Os achados foram similares áqueles verificados na infecção canina natural, bem como na doença humana. Estes resultados sugerem que o cão pode representar um modelo experimental para a infecção causada pela L. b. brasiliensis.

Palavras-Chave: Leishmania braziliensis braziliensis; infecção canina experimental

 

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