SciELO - Scientific Electronic Library Online

vol.83 issue2Enteropathogenic bacteria detected in healthy children from 3 low income communities, in Recife, Permanbuco state, Brazil author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Memórias do Instituto Oswaldo Cruz

Print version ISSN 0074-0276On-line version ISSN 1678-8060

Mem. Inst. Oswaldo Cruz vol.83 no.2 Rio de Janeiro Apr./June. 1988 

Experimental canine mucocutaneous leishmaniasis (Leishmania braziliensis braziliensis)

Claude Pirmez1 

Mauro C. A. Marzochi2 

Sergio G. Coutinho3 

Instituto Oswaldo Cruz, Departamento de Imunologia, Rio de Janeiro, Brasil

FIOCRUZ, Escola Nacional de Saúde Pública, Rio de Janeiro, Brasil

FIOCRUZ, Departamento de Protozoologia, Rio de Janeiro, Brasil


Four mongrel dogs were intradermically inoculated with 3 x 10**6 Leishmania braziliensis braziliensis promastigotes. Three out of the four animals developed cutaneous lesions respectively 4, 7, and 8 months after. The fourth dog did not develop lesion at the inoculation site, but a mucosal ulcer was seen 16 months after the inoculum. Clinical, histopathological, and serological findings were similar to what is found in natural canine infection as well as in the human disease. These results suggest that dogs may be an useful model for L. b. braziliensis infection.


Quatro cães foram inoculados por via intredérmica com 3 x 10**6 promastigotos de Leishmania brasiliensis braziliensis. Três deles desenvolveram lesões no sítio do inóculo, mas uma úlcera mucosa foi detectada 16 meses após o inóculo. Os achados foram similares áqueles verificados na infecção canina natural, bem como na doença humana. Estes resultados sugerem que o cão pode representar um modelo experimental para a infecção causada pela L. b. brasiliensis.


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License