Abstract
The authors investigated the relation between parasites and host-cells in active and regressed lesions of a patient with diffuse cutaneous leishmaniasis, evaluating the frequency of different cell types, and the location and integrity of amastigotes. No correlation was found between parasite integrity and size of parasitophorous vacuoles. They observed ultrastructural findings characterizing a cell mediated immune response: macrophages lysis, parasitic destruction inside macrophages, close contact between parasitized macrophages and lymphocytes and between parasites and lymphocytes, lymphocytic infiltration and fibrosis. They suggest that in DCL there is a limited cellular immune response, although insufficient to control infection.
diffuse cutaneous leishmaniasis; human leishmaniasis; Leishmania; skin biopsie
Distinct ultrastructural aspects in different biopsies of a single patient with diffuse cutaneous leishmaniasis
Achilea Lisboa Bittencourt1
Luiz Antonio Rodrigues de Freitas2
Margarida L. Pompeu3
Maria Lucia Vieira4
Aldina Barral5
UFBa, Hosp. Univ. Prof. Edgard Santos, Departamento de Anatomia Patológica, Salvador, Brasil
Centro de Gonçalo Muniz, Salvador, Brasil
UFCe, Departamento de Patologia, Salvador, Brasil
Centro de Pesquisa Gonçalo Muniz, Hosp. Prof. Edgard Santos, Laboratório de Imunologia, Salvador, Brasil
UFBa, Hosp. Prof. Edgard Santos, Laboratório de Imunologia, Salvador, Brasil
The authors investigated the relation between parasites and host-cells in active and regressed lesions of a patient with diffuse cutaneous leishmaniasis, evaluating the frequency of different cell types, and the location and integrity of amastigotes. No correlation was found between parasite integrity and size of parasitophorous vacuoles. They observed ultrastructural findings characterizing a cell mediated immune response: macrophages lysis, parasitic destruction inside macrophages, close contact between parasitized macrophages and lymphocytes and between parasites and lymphocytes, lymphocytic infiltration and fibrosis. They suggest that in DCL there is a limited cellular immune response, although insufficient to control infection.
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Publication Dates
-
Publication in this collection
24 June 2009 -
Date of issue
Mar 1990
