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vol.85 issue2Experimental chagas' disease in rhesus monkeys. I. Clinical parasitological, hematological and anatomo-pathological studies in the acute and indeterminate phase of the diseaseTrypanosoma nupelianus sp. n. (Protozoa, Kinetoplastida) parasitizing rhinelepis aspera (Osteichthyes, Loricariidae) from Paraná river, Brazil author indexsubject indexarticles search
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Memórias do Instituto Oswaldo Cruz

Print version ISSN 0074-0276On-line version ISSN 1678-8060

Mem. Inst. Oswaldo Cruz vol.85 no.2 Rio de Janeiro Apr./June. 1990 

Trypanosoma cruzi: experimental Chagas' disease in Rhesus monkeys. II. Ultraestructural and cytochemical studies of peroxidase and acid phosphatase activities

Maria de Nazareth Leal de Meirelles

Maria da Glória Bonecini-Almeida1 

Maria Heleosina Ribeiro Pessoa2 

Bernardo Galvão-Castro1 

WHO Colaborating Center for Research and Training in Parasitic Disease, Departamento de Imunologia, Rio de Janeiro, Brasil

Universidade do Estado do Rio de Janeiro, Serviço de Microbiologia e Imunologia, Rio de Janeiro, Brasil


Ultrastructural and cytochemical studies of peroxidase and acid phosphatase were performed in skin, lymph node and heart muscle tissue of thesus monkeys with experimental Chagas's disease. At the site of inoculation ther was a proliferative reaction with the presence of immature macrophages revealed by peroxidase technique. At the lymph node a difuse inflammatory exudate with mononuclear cells, fibroblasts and immature activated macrophages reproduces the human patrtern of acute Chagas' disease inflamatory lesions. The hearth muscle cells present different degrees of degenerative alterations and a striking increase in the number of lysosomal profiles that exhibit acid hydrolase reaction product. A strong inflammatory reaction was present due to lymphocytic infiltrate or due to eosinophil granulocytes associated to ruptured cells. The present study provides some experimental evidences that the monkey model could be used as a reliable model to characterize histopathological alterations of the human disease.

Key words: ultrastructural cytochemistry; peroxidase activity; acid phosphatase; Chagas' disease; rhesus monkeys


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