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Memórias do Instituto Oswaldo Cruz

Print version ISSN 0074-0276On-line version ISSN 1678-8060

Mem. Inst. Oswaldo Cruz vol.86 no.2 Rio de Janeiro Apr./June 1991 

Cellular immune response of humans to the circumsporozoite protein of Plasmodium vivax

Mauricio M. Rodrigues1 

Araripe P. Dutra2 

Nobuko Yoshida3 

New York University, Department of Medical and Molecular Parasitology, New Yourk, s.p

Superintendência de Controle de Endemias, São Paulo, Brasil

Escola Paulista de Medicina, Disciplina de Parasitologia, São Paulo, Brasil


The cellular immune response to the circumsporozoite (CS) protein of plasmodium vivax of individuals from malaria-endemic areas of Brazil was studied. We examined the in vitro proliferative response of the peripheral blood mononuclear cells (PBMC) of 22 individuals when stimulated with a CS recombinant protein (rPvCS-2) and two other synthetic peptides based on the sequenceof the P. vivax CS protein. Seven of the individuals from malaria-endemic area displayed an antigen specific in vitro proliferative responseto the recombinant protein PvCS-2 and one out of 6, proliferative response to the peptide 308-320. In contrast, none of the individuals displayed a proliferative reponse when stimulated with the D/A peptide which represent some of the repeated units present in this CS protein. Our study, therefore, provides evidence for the presence, withinthe major surface antigen of P. vivax sporozoites, of epitopes capble to induce proliferation of human PBMC.


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