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Memórias do Instituto Oswaldo Cruz

Print version ISSN 0074-0276On-line version ISSN 1678-8060

Mem. Inst. Oswaldo Cruz vol.86  suppl.2 Rio de Janeiro  1991

http://dx.doi.org/10.1590/S0074-02761991000600012 

Evaluation of the purified fraction of Wilbrandia (c. f. ) verticillata for antitumour activity

V. S. N. Rao1 

F. R. C. Almeida1 

A. P. Moraes1 

J. V. Silva1 

S. C. Nascimento2 

M. O. Moraes1 

UFC, Departamento de Fisiologia e Farmacologia, Labortório de Pesquisas Antineoplásticas, Fortaleza, Brasil

Universidade Federal de Pernambuco, Departamento de Antibióticos, Recife, Brasil

ABSTRACT

Cucurbatacins are known to produce cytotoxic and anticancer activities. Two novel norcucurbitacin glucosides (Wvl and Wv2) have recently been isolated from a purified fraction obtained from the rhizome of Wilbrandia verticillata. The present study evaluates the cytotoxic and anti-tumour activities of the norcucurbitacins. We have found a regular cytotoxicity in KB cells (Cy50 = 12µg/ml) as well as a significant inhibition in the Walker 256 carcinosarcoma growth (approximately 75%).

Key words: antitumor; Wilbrandia verticillata; cytotoxicity; Walker carcinosarcoma

 

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