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Memórias do Instituto Oswaldo Cruz

Print version ISSN 0074-0276On-line version ISSN 1678-8060

Mem. Inst. Oswaldo Cruz vol.86  suppl.2 Rio de Janeiro  1991

http://dx.doi.org/10.1590/S0074-02761991000600018 

Genotoxic effect of alkaloids

J. A. P. Henriques1 

P. R. H. Moreno2 

G. L. Von Poser2 

C. C. Querol1 

A. T. Henriques2 

UFRGS, Instituto de Biociências, Departamento de Fisiologia, Farmacologia e Biofísica, Porto Alegre, Brasil

UFRGS, Porto Alegre, Brasil

ABSTRACT

Because of the increase use of alkaloids in general medical practice in recent years, it is of interest to determine genotoxic, mutagenic and recombinogenic response to different groups of alkaloids in prokaryotic and eucaryotic organisms. Reserpine, boldine and chelerythrine did not show genotoxicity response in the SOS-Chromotest whereas skimmianine showed genotixicity in the presence of a metabolic activation mixture. Voacristine isolated fromthe leaves of Ervatamia coronaria shows in vivo cytostatic and mutagenic effects in Saccharomyces cerevisiae hapioids cells. The Rauwolfia alkaloid (reserpine) was not able to induce reverse mutation and recombinational mitotic events (crossing-over and gene conversion) in yeast diploid strain XS2316.

Key words: alkaloids; SOS-Chromotest; Saccharomyces cerevisiae; mutation; recombination

 

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