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Memórias do Instituto Oswaldo Cruz

Print version ISSN 0074-0276On-line version ISSN 1678-8060

Mem. Inst. Oswaldo Cruz vol.86  suppl.2 Rio de Janeiro  1991

http://dx.doi.org/10.1590/S0074-02761991000600021 

Toxicological study of the molluscicidal latex of Euphorbia splendens: irritant action on skin and eye

J. C. B. R. Freitas1 

O. A. F. Presgrave1 

F. F. Fingola1 

M. A. C. Menezes1 

M. C. Vasconcellos2 

V. T. Schall2 

F. J. R. Paumgartten1 

Instituto Nacional de Controle de Qualidade em Saúde, Departamento de Farmacologia e Toxicologia, Rio de Janeiro, Brasil

Instituto Oswaldo Cruz, Departamento de Biologia, Rio de Janeiro, Brasil

ABSTRACT

Aqueous solutions of the molluscicidal latex of Euphorbia splendens are irritant to the rabbit eye in concentrations higher than 0.35% and to the rabbit skin in concentrations higher than 0.5%. Although this irritant potential does not proclude its use as a molluscicide, special precautions are recommended for hanbdling and application of the product and the hazard of skin tumor-promoting potencial should be carefully investigated before its use for schistosomiasis vector control.

Key words: Euphorbia splendens; plants molluscicide; schistosomiasis; skin irritation; eye irritation; toxicology

 

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