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Memórias do Instituto Oswaldo Cruz

Print version ISSN 0074-0276

Mem. Inst. Oswaldo Cruz vol.86  suppl.2 Rio de Janeiro  1991

http://dx.doi.org/10.1590/S0074-02761991000600053 

Evaluation of acute administration of natural products with potential diuretic effects, in humansLaranjaSandra M. R.BergamaschiCassia M.SchorNestor Escola Paulista de Medicina, Disciplina de Nefrologia São Paulo Brasil 001991862237240In order to evaluate the potential diuretic effect of two natural products, Elephantopus scaber and Alpinia speciosa, a trial administration was carried out in ten healthy volunteers and the effects compared to the those of a placebo. The substances were given on different days, with a seven day interval between doses. The amount of substance administered to the subjects was five times the usual dose i.e. 7.5 g/100 ml and 0.8 g/100 ml respectively. The following parameters parameteres were measured: urinary and plasma sodium, potassium, uric acid, calcium, phosphate, urea, creatinine. The subjects were also examined clinically and total urinary volume was assessed. The only significant finding (p < 0.05) was a slight diuresis with Alpinia speciosa, which also lowered the diastolic (p < 0.05) and systolic (p < 0.01) blood pressures. No effect on electrolytes or renal function parameters was observed, and this probably excludes any renal tubular or glomerular effect from these substances. Natural productsdiureticsElephantopus scaberAlpinia speciosaFull text available only in PDF format.Texto completo disponível apenas em PDF.