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On-line version ISSN 1678-8060
Mem. Inst. Oswaldo Cruz vol.87 suppl.3 Rio de Janeiro 1992
A chromosome 9 deletion in Plasmodium falciparum results in loss of cytoadherenceKempD. J.ThompsonJ.BarnesD. A.TrigliaT.KaramalisF.PetersenC.BrownG. V.DayK. P. The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital Victoria Australia University of California San Francisco USA Imperial College of Science and Technology London England 0019928738589Many lines of Plasmodium falciparum undrgo a deletion of the right end of chromosome 9 during in vitro culture accompanied by loss of cytoadherence and gametocytogenesis. Selection of cytoadherent cells from a mixed population co-selects for those with an undeleted chromosome 9 and selected cells produce gametocytes. The deletion also results in loss of expression of PfEMP1, the putative cytoadherence ligand, suggesting PfEMP1 or a regulatory gene controlling PfEMP1 expression and gametocytogenesis may be encoded in this region. We have isolated several markers for the deleted region and are currently using a YAC-P. falciparum library to investigate this region of the genome in detail.chromosome deletioncytoadherencePlasmodium falciparumpathologyPfEMP1Full text available only in PDF format.Texto completo disponível apenas em PDF.