Abstract
A vaccine strategy against Babesia divergens bovine babesiosis was sucessfully developed after perfecting of an efficient in vitro culture. Crude supernatants and purified fractions were able to induce a vaccine protection in gerbils against B. divergens infection. More, supernatants induced an effective vaccine protection in cattle. The role of B. divergens exoantigens of 17, 37, 46, 70 and 90 kDa in the development of the immune response was cleary demonstrated in gerbils, cattle, and man.
Babesia divergens; in vitro culture; exoatingen; vaccine
Babesia divergens vaccine
A. Gorenflot1
E. Precigout2
A. Valentin3
G. Bissuel4
B. Carcy1
P. Brasseur5
Y. Moreau4
J. Schrevel1
Faculté de Pharmacie, Laboratoire de Biologie Cellulaire, Montpellier, France
URA CNRS 290, Laboratoire de Biologie Cellulaire, Poitiers, France
URA CNRS 290, Laboratoire de Biologie Cellulaire, Lyon, France
Laboratoire IFFA, Lyon, France
Hôtel Dieu, Laboratoire de Parasitologie, Rouen, France
A vaccine strategy against Babesia divergens bovine babesiosis was sucessfully developed after perfecting of an efficient in vitro culture. Crude supernatants and purified fractions were able to induce a vaccine protection in gerbils against B. divergens infection. More, supernatants induced an effective vaccine protection in cattle. The role of B. divergens exoantigens of 17, 37, 46, 70 and 90 kDa in the development of the immune response was cleary demonstrated in gerbils, cattle, and man.
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Publication Dates
-
Publication in this collection
04 June 2009 -
Date of issue
1992