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Memórias do Instituto Oswaldo Cruz

Print version ISSN 0074-0276On-line version ISSN 1678-8060

Mem. Inst. Oswaldo Cruz vol.87  suppl.3 Rio de Janeiro  1992

http://dx.doi.org/10.1590/S0074-02761992000700066 

Vector incrimination and effects of antimalarial drugs on malaria transmission and control in the Amazon Basin of Brazil

T. A. Klein1 

J. B. P. Lima2 

A Toda Tang3 

Walter Reed Army Institute of Research, Department of Entomology, Washington, USA

APO Miami, American Consulate-Rio, U.S. Army Medical Research Unit-Brazil, Miami, USA

Brasil. Ministério da Saúde, SUCAM, Divisão de Malária. Laboratório Central de Entomologia, Brasília, Brasil

ABSTRACT

World ecosystems differ significantly and a multidisciplinary malaria control approach must be adjusted to meet these requirements. These include a comprehensive understanding of the malaria vectors, their behavior, seasonal distribution and abundance, susceptibility to insecticides (physiological and behavioral), methods to reduce the numbers of human gametocyte carriers through effective health care systems and antimalarial drug treatment, urban malaria transmission versus rural or forest malaria transmission, and the impact of vaccine development. Many malaria vectors are members of species complexes and individual relationship to malaria transmission, seasonal distribution, bitting behavior, etc. is poorly understood. Additionaly, malaria patients are not examined for circulating gametocytes and both falciparum and vivax malaria patients may be highly infective to mosquitoes after treatment with currently used antimalarial drugs. Studies on the physiological and behavioral effects of DDT and other insecticides are inconclusive and need to be evalusted.

Key words: Anopheles darlingi; Anopheles sp.; quinine; tetracycline; chloroquine; malaria; control; Plasmodium; Brazil

 

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