Abstract
Although several animal models for human cerebral malaria have been proposed in the past, name have shown pathological findings that are similar to those seen in humans. In order to develop an animal model for human cerebral malaria, we studied the pathology of brains of Plasmodium coatneyi (primate malaria parasite)-infected rhesus monkeys. Our study demonstrated parazitized erythrocyte (PRBC) sequestration and cytoadherence of knobs on PRBC to endothelial cells in cerebral microvessels of these monkeys. This similar to the findings een in human cerebral malaria. Crebral microvessels with sequestred PRBC were shown by immunohistochemistry to possess CD36, TSP and ICAM-1. These proteins were not evident in cerebral microvessels of uninfected control monkeys. Our study indicates, for the first time, that rhesus monkeys infected with P. coatneyi can be used as a primate model to study human cerebral malaria.
Plasmodium coatneyi; human cerebral malaria; animal model; pathology; rhesus monkeys; brain
Plasmodium coatneyi-infected rhesus monkeys: a primate modelfor human cerebral malaria
Masamichi Aikawa1
Arthur E. Brown2
C. Dahlem Smith2
Tatsuya Tegoshi
Russell J. Howard3
Thomas H. Hasler3
Yoshihiro Ito
William E. Colins4
H. Kyle Webster2
Case Western Reserve University, Institute of Pathology, Cleveland, USA
Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
DNAX Research Institute, Palo Alto, USA
Atlanta. Centers for Disease Control, Malaria Branch, Atlanta, USA
Although several animal models for human cerebral malaria have been proposed in the past, name have shown pathological findings that are similar to those seen in humans. In order to develop an animal model for human cerebral malaria, we studied the pathology of brains of Plasmodium coatneyi (primate malaria parasite)-infected rhesus monkeys. Our study demonstrated parazitized erythrocyte (PRBC) sequestration and cytoadherence of knobs on PRBC to endothelial cells in cerebral microvessels of these monkeys. This similar to the findings een in human cerebral malaria. Crebral microvessels with sequestred PRBC were shown by immunohistochemistry to possess CD36, TSP and ICAM-1. These proteins were not evident in cerebral microvessels of uninfected control monkeys. Our study indicates, for the first time, that rhesus monkeys infected with P. coatneyi can be used as a primate model to study human cerebral malaria.
Full text available only in PDF format.
Texto completo disponível apenas em PDF.
Publication Dates
-
Publication in this collection
04 June 2009 -
Date of issue
1992