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Memórias do Instituto Oswaldo Cruz

Print version ISSN 0074-0276On-line version ISSN 1678-8060

Mem. Inst. Oswaldo Cruz vol.88 no.1 Rio de Janeiro Jan./Mar. 1993 

Isolation of Pseudomonas cepacia in cystic fibrosis patient

Elizabeth de Andrade Marques1 

Rosa Maria Carvalho Pinto2 

Ludma Trotta Dallallana2 

Elsa Fuchshuber Rodrigues de Oliveira1 

Italo Suassuna1 

UERJ, Faculdade de Ciências Médicas, Departamento de Patologia e Laboratórios. Serviço de Microbiologia e Imunologia, Rio de Janeiro, Brasil

FIOCRUZ, Instituto Fernandes Figueira, Setor de Mucoviscidose, Rio de Janeiro, Brasil


Pulmonary infection on cystic fibrosis (CF) patients are associated with a limited qualitative number of microorganisms. During the colonization process, Staphylococcus aureus usually preceedes Pseudomonas aeruginosa. This latter is at first non-mucoid, being replaced or associated to a mucoid morphotype which is rare in other diseases. In 1980, Pseudomonas cepacia appeared as an important agent in CF pulmonary infections with a mean frequency of about 6.1% isolations in different parts of the world. The primus colonization mainly occurs in the presence of pre-existent tissue lesions and the clinical progress of the disease is variable. In some patients it can be fulminant; in others it can cause a gradual and slow decrease in their pulmonary functions. The concern with this germ isolation is justified by its antibiotic multiple resistence and the possibility of direct transmission from a colonized patient to a non-colonized one. We reported the first case of P. cepacia infection in a CF patient in our area. The microbiological attendance to this patient had been made from 1986 to 1991 and the first positive culture appeared in 1988. The sensitivity profile showed that the primus colonization strain was sensitive to 9 of 17 tested antibiotics, however in the last culture the strain was resistent to all antibiotics. These data corroborate the need for monitoring the bacterial flora on CF patients respiratory system.

Key words: Pseudomonas cepacia; cystic fibrosis; pulmonary infection


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